scholarly journals The PAR-6 Polarity Protein Regulates Dendritic Spine Morphogenesis through p190 RhoGAP and the Rho GTPase

2008 ◽  
Vol 14 (2) ◽  
pp. 216-226 ◽  
Author(s):  
Huaye Zhang ◽  
Ian G. Macara
Keyword(s):  
Dendritic Spine ◽  
Rho Gtpase ◽  
P190 Rhogap ◽  
Spine Morphogenesis

scholarly journals Molecular Architecture of Synaptic Actin Cytoskeleton in Hippocampal Neurons Reveals a Mechanism of Dendritic Spine Morphogenesis

2010 ◽  
Vol 21 (1) ◽  
pp. 165-176 ◽  
Author(s):  
Farida Korobova ◽  
Tatyana Svitkina
Keyword(s):  
Electron Microscopy ◽  
Actin Cytoskeleton ◽  
Actin Filament ◽  
Dendritic Spines ◽  
Dendritic Spine ◽  
Myosin Ii ◽  
Capping Protein ◽  
Dominant Feature ◽  
Presynaptic Boutons ◽  
Spine Morphogenesis

Excitatory synapses in the brain play key roles in learning and memory. The formation and functions of postsynaptic mushroom-shaped structures, dendritic spines, and possibly of presynaptic terminals, rely on actin cytoskeleton remodeling. However, the cytoskeletal architecture of synapses remains unknown hindering the understanding of synapse morphogenesis. Using platinum replica electron microscopy, we characterized the cytoskeletal organization and molecular composition of dendritic spines, their precursors, dendritic filopodia, and presynaptic boutons. A branched actin filament network containing Arp2/3 complex and capping protein was a dominant feature of spine heads and presynaptic boutons. Surprisingly, the spine necks and bases, as well as dendritic filopodia, also contained a network, rather than a bundle, of branched and linear actin filaments that was immunopositive for Arp2/3 complex, capping protein, and myosin II, but not fascin. Thus, a tight actin filament bundle is not necessary for structural support of elongated filopodia-like protrusions. Dynamically, dendritic filopodia emerged from densities in the dendritic shaft, which by electron microscopy contained branched actin network associated with dendritic microtubules. We propose that dendritic spine morphogenesis begins from an actin patch elongating into a dendritic filopodium, which tip subsequently expands via Arp2/3 complex-dependent nucleation and which length is modulated by myosin II-dependent contractility.

scholarly journals Regulation of dendritic spine morphology by an NMDA receptor-associated Rho GTPase-activating protein, p250GAP

2008 ◽  
Vol 105 (4) ◽  
pp. 1384-1393 ◽  
Author(s):  
Takanobu Nakazawa ◽  
Toshihiko Kuriu ◽  
Tohru Tezuka ◽  
Hisashi Umemori ◽  
Shigeo Okabe ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Dendritic Spine ◽  
Rho Gtpase ◽  
Gtpase Activating Protein ◽  
Spine Morphology ◽  
Dendritic Spine Morphology

PLD1 promotes dendritic spine morphogenesis via activating PKD1

2019 ◽  
Vol 99 ◽  
pp. 103394 ◽  
Author(s):  
Wen-Qi Li ◽  
Li-Da Luo ◽  
Zhi-Wen Hu ◽  
Tian-Jie Lyu ◽  
Cheng Cen ◽  
...  
Keyword(s):  
Dendritic Spine ◽  
Spine Morphogenesis

Role of actin cytoskeleton in dendritic spine morphogenesis

2007 ◽  
Vol 51 (2-4) ◽  
pp. 92-104 ◽  
Author(s):  
Yuko Sekino ◽  
Nobuhiko Kojima ◽  
Tomoaki Shirao
Keyword(s):  
Actin Cytoskeleton ◽  
Dendritic Spine ◽  
Spine Morphogenesis

scholarly journals Cadherin Regulates Dendritic Spine Morphogenesis

Neuron ◽  
2002 ◽  
Vol 35 (1) ◽  
pp. 77-89 ◽  
Author(s):  
Hideru Togashi ◽  
Kentaro Abe ◽  
Akira Mizoguchi ◽  
Kanna Takaoka ◽  
Osamu Chisaka ◽  
...  
Keyword(s):  
Dendritic Spine ◽  
Spine Morphogenesis

scholarly journals Analysis and Modeling of Dendritic Spine Morphogenesis

2014 ◽  
Vol 106 (2) ◽  
pp. 424a-425a
Author(s):  
Olena Marchenko ◽  
Charles W. Wolgemuth ◽  
Leslie M. Loew
Keyword(s):  
Dendritic Spine ◽  
Spine Morphogenesis
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