scholarly journals The REF-1 Family of bHLH Transcription Factors Pattern C. elegans Embryos through Notch-Dependent and Notch-Independent Pathways

2005 ◽  
Vol 8 (6) ◽  
pp. 867-879 ◽  
Author(s):  
Alexandre Neves ◽  
James R. Priess
Keyword(s):  
Transcription Factors ◽  
C Elegans ◽  
Bhlh Transcription Factors

scholarly journals Multiple neural bHLHs ensure the precision of a neuronal specification event in C. elegans

Biology Open ◽  
2021 ◽  
Author(s):  
Konstantina Filippopoulou ◽  
Carole Couillault ◽  
Vincent Bertrand
Keyword(s):  
Transcription Factors ◽  
Quantitative Imaging ◽  
Terminal Differentiation ◽  
Cholinergic Neurons ◽  
Antagonistic Effect ◽  
Specific Class ◽  
C Elegans ◽  
Neuronal Specification ◽  
Bhlh Transcription Factors ◽  
Deleterious Genes

Neural bHLH transcription factors play a key role in the early steps of neuronal specification in many animals. We have previously observed that the Achaete-Scute HLH-3, the Olig HLH-16 and their binding partner the E protein HLH-2 activate the terminal differentiation program of a specific class of cholinergic neurons, AIY, in C. elegans. Here we identify a role for a fourth bHLH, the Neurogenin NGN-1, in this process, raising the question of why so many neural bHLHs are required for a single neuronal specification event. Using quantitative imaging we show that the combined action of different bHLHs is needed to activate the correct level of expression of the terminal selector transcription factors TTX-3 and CEH-10 that subsequently initiate and maintain the expression of a large battery of terminal differentiation genes. Surprisingly, the different bHLHs have an antagonistic effect on another target, the proapoptotic BH3-only factor EGL-1, normally not expressed in AIY and otherwise detrimental for its specification. We propose that the use of multiple neural bHLHs allows robust neuronal specification while, at the same time, preventing spurious activation of deleterious genes.

scholarly journals Piecemeal regulation of convergent neuronal lineages by bHLH transcription factors in Caenorhabditis elegans

Development ◽  
2021 ◽  
Vol 148 (11) ◽  
Author(s):  
Neda Masoudi ◽  
Eviatar Yemini ◽  
Ralf Schnabel ◽  
Oliver Hobert
Keyword(s):  
Transcription Factors ◽  
Caenorhabditis Elegans ◽  
Contralateral Side ◽  
Mirror Image ◽  
Neuronal Markers ◽  
C Elegans ◽  
Helix Loop Helix ◽  
Distinct Lineage ◽  
Bhlh Transcription Factors ◽  
Identity Transformations

ABSTRACT Cells of the same type can be generated by distinct cellular lineages that originate in different parts of the developing embryo (‘lineage convergence’). Several Caenorhabditis elegans neuron classes composed of left/right or radially symmetric class members display such lineage convergence. We show here that the C. elegans Atonal homolog lin-32 is differentially expressed in neuronal lineages that give rise to left/right or radially symmetric class members. Loss of lin-32 results in the selective loss of the expression of pan-neuronal markers and terminal selector-type transcription factors that confer neuron class-specific features. Another basic helix-loop-helix (bHLH) gene, the Achaete-Scute homolog hlh-14, is expressed in a mirror image pattern relative to lin-32 and is required to induce neuronal identity and terminal selector expression on the contralateral side of the animal. These findings demonstrate that distinct lineage histories converge via different bHLH factors at the level of induction of terminal selector identity determinants, which thus serve as integrators of distinct lineage histories. We also describe neuron-to-neuron identity transformations in lin-32 mutants, which we propose to also be the result of misregulation of terminal selector gene expression.

scholarly journals A Multiparameter Network Reveals Extensive Divergence between C. elegans bHLH Transcription Factors

Cell ◽  
2009 ◽  
Vol 138 (2) ◽  
pp. 314-327 ◽  
Author(s):  
Christian A. Grove ◽  
Federico De Masi ◽  
M. Inmaculada Barrasa ◽  
Daniel E. Newburger ◽  
Mark J. Alkema ◽  
...  
Keyword(s):  
Transcription Factors ◽  
C Elegans ◽  
Bhlh Transcription Factors

scholarly journals The C. elegans Snail homolog CES-1 can activate gene expression in vivo and share targets with bHLH transcription factors

2009 ◽  
Vol 37 (11) ◽  
pp. 3689-3698 ◽  
Author(s):  
John S. Reece-Hoyes ◽  
Bart Deplancke ◽  
M. Inmaculada Barrasa ◽  
Julia Hatzold ◽  
Ryan B. Smit ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factors ◽  
C Elegans ◽  
Bhlh Transcription Factors ◽  
Activate Gene

scholarly journals 1P123 DMA binding analyses of bHLH transcription factors by FRET measurements(Nucleic acid-binding proteins,Poster Presentations)

2007 ◽  
Vol 47 (supplement) ◽  
pp. S54
Author(s):  
Koji HASEGAWA ◽  
Tatsushi GOTO ◽  
Daisuke KITANO ◽  
Mari KOTOURA ◽  
Fumio TOKUNAGA ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Nucleic Acid ◽  
Binding Proteins ◽  
Nucleic Acid Binding ◽  
Nucleic Acid Binding Proteins ◽  
Poster Presentations ◽  
Bhlh Transcription Factors
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