<div>
<div>
<div>
<p>Here we show the
development of heterobifunctional small molecules capable of selectively targeting MCL1 using
a Proteolysis Targeting Chimera (PROTAC) methodology leading to successful degradation. We
have confirmed the involvement of the E3 ligase CUL4A-DDB1 cereblon (CRBN) ubiquitination
pathway, making these PROTACs a first step toward a new class of anti-apoptotic BCL-2 family
protein degraders.
</p>
</div>
</div>
</div>
Identification of 40LoVe, a Xenopus hnRNP D Family Protein Involved in Localizing a TGF-β-Related mRNA during Oogenesis