Changes in somatic sodium currents of ganglion cells during retinal regeneration in the adult newt

2005 ◽  
Vol 154 (1) ◽  
pp. 25-34 ◽  
Author(s):  
Chikafumi Chiba ◽  
Hanako Oi ◽  
Takehiko Saito
Keyword(s):  
Ganglion Cells ◽  
Retinal Regeneration ◽  
Sodium Currents ◽  
Adult Newt

scholarly journals Characterization of retinal regeneration in adult zebrafish following multiple rounds of phototoxic lesion

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e5646 ◽  
Author(s):  
Alexandra H. Ranski ◽  
Ashley C. Kramer ◽  
Gregory W. Morgan ◽  
Jennifer L. Perez ◽  
Ryan Thummel
Keyword(s):  
Cell Cycle ◽  
Cellular Localization ◽  
Ganglion Cells ◽  
Plexiform Layer ◽  
Inner Plexiform Layer ◽  
Muller Glia ◽  
Müller Glia ◽  
Light Damage ◽  
Retinal Regeneration ◽  
Adult Zebrafish

Müller glia in the zebrafish retina respond to retinal damage by re-entering the cell cycle, which generates large numbers of retinal progenitors that ultimately replace the lost neurons. In this study we compared the regenerative outcomes of adult zebrafish exposed to one round of phototoxic treatment with adult zebrafish exposed to six consecutive rounds of phototoxic treatment. We observed that Müller glia continued to re-enter the cell cycle to produce clusters of retinal progenitors in zebrafish exposed to multiple rounds of phototoxic light. Some abnormalities were noted, however. First, we found that retinas exposed to multiple rounds of damage exhibited a greater loss of photoreceptors at 36 hours of light damage than retinas that were exposed to their first round of light damage. In addition, we found that Müller glia appeared to have an increase in the acute gliotic response in retinas exposed to multiple rounds of light treatment. This was evidenced by cellular hypertrophy, changes in GFAP cellular localization, and transient increases in stat3 and gfap expression. Finally, following the sixth round of phototoxic lesion, we observed a significant increase in mis-localized HuC/D-positive amacrine and ganglion cells in the inner plexiform layer and outer retina, and a decreased number of regenerated blue cone photoreceptors. These data add to recent findings that retinal regeneration in adult zebrafish occurs concomitant with Müller glia reactivity and can result in the generation of aberrant neurons. These data are also the first to demonstrate that Müller glia appear to modify their phenotype in response to multiple rounds of phototoxic lesion, exhibiting an increase in acute gliosis while maintaining a remarkable capacity for long-term regeneration of photoreceptors.

scholarly journals Cadherin Expression during Retinal Regeneration in the Adult Newt

2001 ◽  
Vol 18 (2) ◽  
pp. 145-149 ◽  
Author(s):  
Kiyonori Hirota ◽  
Yuko Kaneko ◽  
Gen Matsumoto ◽  
Yoshiro Hanyu
Keyword(s):  
Retinal Regeneration ◽  
Adult Newt

scholarly journals Implications of a Multi-Step Trigger of Retinal Regeneration in the Adult Newt

Biomedicines ◽  
2017 ◽  
Vol 5 (4) ◽  
pp. 25 ◽  
Author(s):  
Hirofumi Yasumuro ◽  
Keisuke Sakurai ◽  
Fubito Toyama ◽  
Fumiaki Maruo ◽  
Chikafumi Chiba
Keyword(s):  
Retinal Regeneration ◽  
Adult Newt

Visual cycle protein RPE65 persists in new retinal cells during retinal regeneration of adult newt

2006 ◽  
Vol 495 (4) ◽  
pp. 391-407 ◽  
Author(s):  
Chikafumi Chiba ◽  
Akika Hoshino ◽  
Kenta Nakamura ◽  
Kanako Susaki ◽  
Yuka Yamano ◽  
...  
Keyword(s):  
Visual Cycle ◽  
Retinal Regeneration ◽  
Retinal Cells ◽  
Adult Newt
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