Binge ethanol exposure delays development of GABAergic miniature postsynaptic currents in septal neurons

2004 ◽  
Vol 152 (2) ◽  
pp. 199-212 ◽  
Author(s):  
Dustin W. DuBois ◽  
Alan R. Parrish ◽  
Jerome P. Trzeciakowski ◽  
Gerald D. Frye
Keyword(s):  
Ethanol Exposure ◽  
Postsynaptic Currents ◽  
Septal Neurons ◽  
Binge Ethanol Exposure ◽  
Binge Ethanol

scholarly journals Adolescent intermittent ethanol exposure induces sex-dependent divergent changes in ethanol drinking and motor activity in adulthood in C57BL/6J mice

2020 ◽  
Author(s):  
Antoniette M. Maldonado-Devincci ◽  
Joseph G. Makdisi ◽  
Andrea M. Hill ◽  
Renee C. Waters ◽  
Nzia I. Hall ◽  
...  
Keyword(s):  
Open Field ◽  
Ethanol Consumption ◽  
Ethanol Exposure ◽  
Male Mice ◽  
Open Field Behavior ◽  
Male And Female ◽  
Female Mice ◽  
Binge Ethanol Exposure ◽  
Binge Ethanol

AbstractWith alcohol readily accessible to adolescents, its consumption leads to many adverse effects, including impaired learning, attention, and behavior. Adolescents report higher rates of binge drinking compared to adults. Adolescents are also more prone to substance use disorder during adulthood due to physiological changes during the adolescent developmental period. We used C57BL/6J male and female mice to investigate the long-lasting impact of binge ethanol exposure during adolescence on voluntary ethanol intake and open field behavior during later adolescence and in young adulthood. The present set of experiments were divided into four stages: (1) chronic intermittent vapor inhalation exposure, (2) abstinence, (3) voluntary ethanol intake, and (4) open field behavioral testing. During adolescence, male and female mice were exposed to air or ethanol using an intermittent vapor inhalation with repeated binge pattern ethanol exposure from postnatal day (PND) 28–42. Following this, mice underwent abstinence during late adolescence from PND 43–49 (Experiment 1) or PND 43–69 (Experiment 2). Beginning on PND 49–76 (Experiment 1) or PND 70–97 (Experiment 2), mice were assessed for intermittent voluntary ethanol consumption using a two-bottle drinking procedure over 28 days. Male mice that were exposed to ethanol during adolescence showed increased ethanol consumption during later adolescence (Experiment 1) and in emerging adulthood (Experiment 2), while the female mice showed decreased ethanol consumption. These data demonstrate a sexually divergent shift in ethanol consumption following binge ethanol exposure during adolescence and differences in open field behavior. These data highlight sex-dependent vulnerability to developing substance use disorders in adulthood.Significance StatementCurrently, it is vital to determine the sex-dependent impact of binge alcohol exposure during adolescence, given that until recently females have largely been ignored. Here we show that adolescent male mice that are exposed to binge ethanol during adolescence show long-term changes in behavior in adulthood. In contrast, female mice show a transient decrease in ethanol consumption in adulthood and decreased motor activity spent in the center zone of the open field test. Male mice appear to be more susceptible to the long-term changes in ethanol consumption following binge ethanol exposure during adolescence.

scholarly journals Cholinergic system and exploratory behavior are changed after weekly-binge ethanol exposure in zebrafish

2019 ◽  
Vol 186 ◽  
pp. 172790 ◽  
Author(s):  
Henrique Teza Bernardo ◽  
Jotele Fontana Agostini ◽  
Helena Cristina Zuehl Dal Toé ◽  
Karine Medeiros Vieira ◽  
Samira Leila Baldin ◽  
...  
Keyword(s):  
Exploratory Behavior ◽  
Cholinergic System ◽  
Ethanol Exposure ◽  
Binge Ethanol Exposure ◽  
Binge Ethanol

Hyperlocomotion and anxiety- like behavior induced by binge ethanol exposure in rat neonates. Possible ameliorative effects of Omega 3

2019 ◽  
Vol 372 ◽  
pp. 112022 ◽  
Author(s):  
Verónica Balaszczuk ◽  
Juan Agustín Salguero ◽  
Ruth Noelia Villarreal ◽  
Rocio Gala Scaramuzza ◽  
Santiago Mendez ◽  
...  
Keyword(s):  
Ethanol Exposure ◽  
Omega 3 ◽  
Binge Ethanol Exposure ◽  
Binge Ethanol
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