Expression of the winged helix/forkhead gene, foxn4, during zebrafish development

2004 ◽  
Vol 153 (1) ◽  
pp. 115-119 ◽  
Author(s):  
Nadia Danilova ◽  
Axel Visel ◽  
Catherine E. Willett ◽  
Lisa A. Steiner
Keyword(s):  
Winged Helix ◽  
Zebrafish Development ◽  
Forkhead Gene

AmphiFoxQ2, a novel winged helix/forkhead gene, exclusively marks the anterior end of the amphioxus embryo

2003 ◽  
Vol 213 (2) ◽  
pp. 102-105 ◽  
Author(s):  
Jr-Kai Yu ◽  
Nicholas D. Holland ◽  
Linda Z. Holland
Keyword(s):  
Winged Helix ◽  
Forkhead Gene

scholarly journals An amphioxus winged helix/forkhead gene,AmphiFoxD: Insights into vertebrate neural crest evolution

2002 ◽  
Vol 225 (3) ◽  
pp. 289-297 ◽  
Author(s):  
Jr-Kai Yu ◽  
Nicholas D. Holland ◽  
Linda Z. Holland
Keyword(s):  
Neural Crest ◽  
Winged Helix ◽  
Forkhead Gene

scholarly journals A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle

2000 ◽  
Vol 14 (2) ◽  
pp. 245-254 ◽  
Author(s):  
Åsa Blixt ◽  
Margit Mahlapuu ◽  
Marjo Aitola ◽  
Markku Pelto-Huikko ◽  
Sven Enerbäck ◽  
...  
Keyword(s):  
Lens Epithelium ◽  
Epithelial Proliferation ◽  
Proliferating Cells ◽  
Winged Helix ◽  
Lens Fibers ◽  
Lens Vesicle ◽  
Normal Lens ◽  
Winged Helix Transcription Factor ◽  
Forkhead Gene ◽  
Lens Placode

In the mouse mutant dysgenetic lens (dyl) the lens vesicle fails to separate from the ectoderm, causing a fusion between the lens and the cornea. Lack of a proliferating anterior lens epithelium leads to absence of secondary lens fibers and a dysplastic, cataractic lens. We report the cloning of a gene, FoxE3, encoding a forkhead/winged helix transcription factor, which is expressed in the developing lens from the start of lens placode induction and becomes restricted to the anterior proliferating cells when lens fiber differentiation begins. We show thatFoxE3 is colocalized with dyl in the mouse genome, thatdyl mice have mutations in the part of FoxE3 encoding the DNA-binding domain, and that these mutations cosegregate with thedyl phenotype. During embryonic development, the primordial lens epithelium is formed in an apparently normal way in dylmutants. However, instead of the proliferation characteristic of a normal lens epithelium, the posterior of these cells fail to divide and show signs of premature differentiation, whereas the most anterior cells are eliminated by apoptosis. This implies that FoxE3 is essential for closure of the lens vesicle and is a factor that promotes survival and proliferation, while preventing differentiation, in the lens epithelium.

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