Vitamin E amelioration of ethanol neurotoxicity involves modulation of apoptotis-related protein levels in neonatal rat cerebellar granule cells

2004 ◽  
Vol 150 (2) ◽  
pp. 117-124 ◽  
Author(s):  
Marieta Barrow Heaton ◽  
Irina Madorsky ◽  
Michael Paiva ◽  
Kendra I Siler-Marsiglio
Keyword(s):  
Vitamin E ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Neonatal Rat ◽  
Related Protein ◽  
Cerebellar Granule ◽  
Protein Levels

Ethanol-induced reduction of neurotrophin secretion in neonatal rat cerebellar granule cells is mitigated by vitamin E

2004 ◽  
Vol 370 (1) ◽  
pp. 51-54 ◽  
Author(s):  
Marieta Barrow Heaton ◽  
Irina Madorsky ◽  
Michael Paiva ◽  
Kendra I. Siler-Marsiglio
Keyword(s):  
Vitamin E ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Neonatal Rat ◽  
Cerebellar Granule

scholarly journals Vitamin E blocks early events induced by 1-methyl-4-phenylpyridinium (MPP+) in cerebellar granule cells

2003 ◽  
Vol 84 (2) ◽  
pp. 305-315 ◽  
Author(s):  
Rosa A. González-Polo ◽  
Germán Soler ◽  
Alberto Alvarez ◽  
Isabel Fabregat ◽  
José M. Fuentes
Keyword(s):  
Vitamin E ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Cerebellar Granule

Vitamin E enhances Ca2+-mediated vulnerability of immature cerebellar granule cells to ischemia

1998 ◽  
Vol 25 (7) ◽  
pp. 793-802 ◽  
Author(s):  
Vladimir A Dyatlov ◽  
Victoria V Makovetskaia ◽  
Ralph Leonhardt ◽  
David A Lawrence ◽  
David O Carpenter
Keyword(s):  
Vitamin E ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Cerebellar Granule

scholarly journals Tissue specificity and regulation of the N-terminal diversity of reticulon 3

2004 ◽  
Vol 385 (1) ◽  
pp. 125-134 ◽  
Author(s):  
Franck DI SCALA ◽  
Luc DUPUIS ◽  
Christian GAIDDON ◽  
Marc DE TAPIA ◽  
Natasa JOKIC ◽  
...  
Keyword(s):  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Granule Neurons ◽  
Cerebellar Granule ◽  
Preferential Expression ◽  
Protein Levels ◽  
The Central Nervous System ◽  
Cerebellum Development ◽  
Promoter Usage

Over the last few years, the widely distributed family of reticulons (RTNs) is receiving renewed interest because of the implication of RTN4/Nogo in neurite regeneration. Four genes were identified in mammals and are referred to as RTN1, 2, 3 and the neurite outgrowth inhibitor RTN4/Nogo. In the present paper, we describe the existence of five new isoforms of RTN3 that differ in their N-termini, and analysed their tissue distribution and expression in neurons. We redefined the structure of human and murine rtn3 genes, and identified two supplementary exons that may generate up to seven putative isoforms arising by alternative splicing or differential promoter usage. We confirmed the presence of five of these isoforms at the mRNA and protein levels, and showed their preferential expression in the central nervous system. We analysed rtn3 expression in the cerebellum further, and observed increased levels of several of the RTN3 isoforms during cerebellum development and during in vitro maturation of cerebellar granule cells. This pattern of expression paralleled that shown by RTN4/Nogo isoforms. Specifically, RTN3A1 expression was down-regulated upon cell death of cerebellar granule neurons triggered by potassium deprivation. Altogether, our results demonstrate that the rtn3 gene generates multiple isoforms varying in their N-termini, and that their expression is tightly regulated in neurons. These findings suggest that RTN3 isoforms may contribute, by as yet unknown mechanisms, to neuronal survival and plasticity.

scholarly journals Cbln1 Is Essential for Interaction-Dependent Secretion of Cbln3

2006 ◽  
Vol 26 (24) ◽  
pp. 9327-9337 ◽  
Author(s):  
Dashi Bao ◽  
Zhen Pang ◽  
Marc A. Morgan ◽  
Jennifer Parris ◽  
Yongqi Rong ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Glutamate Receptor ◽  
Knockout Mice ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Structure And Function ◽  
Related Protein ◽  
Cerebellar Granule ◽  
Steric Clash ◽  
And Function

ABSTRACT Cbln1 and the orphan glutamate receptor GluRδ2 are pre- and postsynaptic components, respectively, of a novel transneuronal signaling pathway regulating synapse structure and function. We show here that Cbln1 is secreted from cerebellar granule cells in complex with a related protein, Cbln3. However, cbln1- and cbln3-null mice have different phenotypes and cbln1 cbln3 double-null mice have deficits identical to those of cbln1 knockout mice. The basis for these discordant phenotypes is that Cbln1 and Cbln3 reciprocally regulate each other's degradation and secretion such that cbln1-null mice lack both Cbln1 and Cbln3, whereas cbln3-null mice lack Cbln3 but have an approximately sixfold increase in Cbln1. Unlike Cbln1, Cbln3 cannot form homomeric complexes and is secreted only when bound to Cbln1. Structural modeling and mutation analysis reveal that, by constituting a steric clash that is masked upon binding Cbln1 in a “hide-and-run” mechanism of endoplasmic reticulum retention, a single arginine confers the unique properties of Cbln3.

scholarly journals The role of Ca 2+ stores in the muscarinic inhibition of the K + current I K(SO) in neonatal rat cerebellar granule cells

2000 ◽  
Vol 529 (2) ◽  
pp. 321-331 ◽  
Author(s):  
David F. Boyd ◽  
Julie A. Millar ◽  
Christopher S. Watkins ◽  
Alistair Mathie
Keyword(s):  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Neonatal Rat ◽  
Cerebellar Granule ◽  
K Current

Pycnogenol® and vitamin E inhibit ethanol-induced apoptosis in rat cerebellar granule cells

2004 ◽  
Vol 59 (3) ◽  
pp. 261-271 ◽  
Author(s):  
Kendra I. Siler-Marsiglio ◽  
Gerry Shaw ◽  
Marieta B. Heaton
Keyword(s):  
Vitamin E ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Cerebellar Granule ◽  
Induced Apoptosis
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