Sex differences in rapid auditory processing deficits in microgyric rats

2004 ◽  
Vol 148 (1) ◽  
pp. 53-57 ◽  
Author(s):  
Ann M. Peiffer ◽  
Glenn D. Rosen ◽  
R.Holly Fitch
Neuroreport ◽  
2002 ◽  
Vol 13 (17) ◽  
pp. 2277-2280 ◽  
Author(s):  
Ann M. Peiffer ◽  
Glenn D. Rosen ◽  
R. Holly Fitch

2000 ◽  
Vol 12 (5) ◽  
pp. 828-839 ◽  
Author(s):  
Matthew G. Clark ◽  
Glenn D. Rosen ◽  
Paula Tallal ◽  
R. Holly Fitch

Individuals with developmental language disabilities, including developmental dyslexia and specific language impairment (SLI), exhibit impairments in processing rapidly presented auditory stimuli. It has been hypothesized that these deficits are associated with concurrent deficits in speech perception and, in turn, impaired language development. Additionally, postmortem analyses of human dyslexic brains have revealed the presence of focal neocortical malformations such as cerebrocortical microgyria. In an initial study bridging these research domains, we found that male rats with induced microgyria were impaired in discriminating rapidly presented auditory stimuli. In order to further assess this anatomical-behavioral association, we designed two experiments using auditory-reflex modification. These studies were intended to assess whether auditory processing deficits in microgyric male rats would be seen in threshold detection of a silent gap in white noise, and in oddball detection of a two-tone stimulus of variable duration. Results showed no differences between sham and microgyric subjects on gap detection, but did show that microgyric subjects were impaired in the discrimination of two-tone stimuli presented in an oddball paradigm. This impairment was evident for stimuli with total duration of 64 msec or less, while both groups were able to discriminate stimuli with duration of 89 msec or greater. The current results further support the relationship between malformations of the cerebral cortex and deficits in rapid auditory processing. They also suggest that the parameters characterizing rapid auditory processing deficits for a specific task may be influenced by stimulus features and/or cognitive demand of that particular task.


Neuroreport ◽  
2004 ◽  
Vol 15 (12) ◽  
pp. 1923-1926 ◽  
Author(s):  
Ann M. Peiffer ◽  
Melissa M. McClure ◽  
Steven W. Threlkeld ◽  
Glenn D. Rosen ◽  
R. Holly Fitch

2006 ◽  
Vol 1109 (1) ◽  
pp. 22-31 ◽  
Author(s):  
Steven W. Threlkeld ◽  
Melissa M. McClure ◽  
Glenn D. Rosen ◽  
R. Holly Fitch

1983 ◽  
Vol 48 (1) ◽  
pp. 36-40 ◽  
Author(s):  
Peter W. Zinkus ◽  
Marvin I. Gottlieb

Auditory processing deficits and articulation disorders were studied in a group of male juvenile delinquents. Significant auditory processing deficits were frequently observed and were significantly related to underachievement in reading, spelling, and arithmetic. In addition, articulation disorders were present in over 60% of the delinquent subjects. The results are interpreted to indicate that the evaluation of speech capabilities and auditory processing skills should be an integral part of treatment programs for delinquent populations. The importance of early intervention through identification and treatment of speech and language disorders in the early school period is supported.


2018 ◽  
Vol 44 (suppl_1) ◽  
pp. S78-S78
Author(s):  
Susan Rossell ◽  
Eric Tan ◽  
Nathan Wilson ◽  
Wei Lin Toh ◽  
Sean Carruthers ◽  
...  

PEDIATRICS ◽  
1980 ◽  
Vol 66 (2) ◽  
pp. 246-253
Author(s):  
Peter W. Zinkus ◽  
Marvin I. Gottlieb

The effects of chronic otitis media during the first three years of life on developing auditory processing skills were examined. Two groups of children with auditory processing deficits were compared in areas of language development, intellectual factors, auditory processing skills, and academic capabilities. One group of children with auditory processing deficits had a history of severe chronic otitis media during the first three years of life, whereas a second group had auditory processing deficits but no history of early middle ear infections. The results indicate that subjects who had a history of chronic otitis media were slower in developing word combinations, had depressed verbal intelligence scores, manifested pervasive auditory processing deficits, and were significantly poorer in reading. A profile has been constructed that permits early detection of the child at risk.


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