Does drug abuse beget drug abuse? Behavioral analysis of addiction liability in animal models of prenatal drug exposure

2003 ◽  
Vol 147 (1-2) ◽  
pp. 47-57 ◽  
Author(s):  
C.J. Malanga ◽  
Barry E. Kosofsky
Keyword(s):  
Drug Abuse ◽  
Animal Models ◽  
Drug Exposure ◽  
Prenatal Drug Exposure ◽  
Behavioral Analysis

scholarly journals Drugs in Pregnancy: the Effects on Mother and Her Progeny

2012 ◽  
pp. S123-S135
Author(s):  
R. ŠLAMBEROVÁ
Keyword(s):  
Drug Abuse ◽  
Maternal Behavior ◽  
Drug Exposure ◽  
Developed Countries ◽  
Prenatal Drug Exposure ◽  
Placental Barrier ◽  
Maternal Milk ◽  
The World ◽  
Abuse During Pregnancy ◽  
In Pregnancy

Drug abuse during pregnancy is a growing problem in all developed countries all over the world. The drugs easily cross the placental barrier into the fetal body and are present also in the maternal milk. Therefore, it may affect the development of the child pre- as well as postnatally. The effects of prenatal drug exposure are long-lasting and persist until adulthood. The present review summarizes the clinical and experimental evidence showing how opioids and psychostimulants can affect maternal behavior of drug-abusing mother and the development of their offspring.

Pediatric Psychopharmacology and the Interaction between Drugs and the Developing Brain

1998 ◽  
Vol 43 (6) ◽  
pp. 582-584 ◽  
Author(s):  
Benedetto Vitiello
Keyword(s):  
Drug Exposure ◽  
Imaging Techniques ◽  
Quantitative Imaging ◽  
Adult Life ◽  
Prenatal Drug Exposure ◽  
Developing Brain ◽  
Teratogenic Effects ◽  
Pharmacological Agents ◽  
Early Inhibition ◽  
Interaction Between Drugs

With increasing frequency, psychotropic medications are being prescribed to young children, often for long periods of time. The interaction between psychotropics and the developing brain has not been systematically investigated in humans. Data collected from animals suggest that developing neurotransmitter systems can be exquisitely sensitive to early inhibition or stimulation by pharmacological agents, which can lead to permanent changes in adult life. Most of these data are collected from rodents, and their extrapolation to humans is difficult. More relevant models could be developed, for instance using primates. In humans, the focus of research has traditionally been on the possible teratogenic effects of prenatal drug exposure. Recently introduced quantitative imaging techniques can offer new approaches to studying the effects of psychotropics on the developing brain. This research has clear implications for the safety and efficacy of psychopharmacologic drug use in children.

Intelligence and School Readiness in Preschool Children With Prenatal Drug Exposure

2004 ◽  
Vol 10 (2) ◽  
pp. 89-101 ◽  
Author(s):  
Margaret B. Pulsifer ◽  
Krestin Radonovich ◽  
Harolyn M.E. Belcher ◽  
Arlene M. Butz
Keyword(s):  
Preschool Children ◽  
School Readiness ◽  
Drug Exposure ◽  
Prenatal Drug Exposure

Monitoring pregnancy outcomes following prenatal drug exposure through prospective pregnancy registries and passive surveillance: a pharmaceutical company commitment

1998 ◽  
Vol 5 (4) ◽  
pp. 190-191 ◽  
Author(s):  
Robbin R. Eldridge ◽  
Sara A. Ephross ◽  
Cindy R. Heffner ◽  
Patricia S. Tennis ◽  
Dr.Monika Stender ◽  
...  
Keyword(s):  
Pharmaceutical Company ◽  
Pregnancy Outcomes ◽  
Drug Exposure ◽  
Prenatal Drug Exposure ◽  
Passive Surveillance
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