Effect of tumor necrosis factor alpha and infliximab on apoptosis of B lymphocytes infected or not with Epstein–Barr virus

Cytokine ◽  
2006 ◽  
Vol 33 (6) ◽  
pp. 337-345 ◽  
Author(s):  
F BARANMARSZAK ◽  
C LAGUILLIER ◽  
I YOULYOUZ ◽  
J FEUILLARD ◽  
X MARIETTE ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
B Lymphocytes ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Epstein Barr Virus ◽  
Necrosis Factor Alpha ◽  
Barr Virus ◽  
Factor Alpha ◽  
Epstein Barr ◽  
Necrosis Factor

Elevated Tumor Necrosis Factor-alpha Expression in Periapical Lesions Infected by Epstein-Barr Virus

2013 ◽  
Vol 39 (4) ◽  
pp. 456-460 ◽  
Author(s):  
Katinka Hernádi ◽  
Eszter Gyöngyösi ◽  
Beáta Mészáros ◽  
Levente Szakács ◽  
Anita Szalmás ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Epstein Barr Virus ◽  
Necrosis Factor Alpha ◽  
Periapical Lesions ◽  
Barr Virus ◽  
Factor Alpha ◽  
Epstein Barr ◽  
Necrosis Factor

scholarly journals EBNA2 Is Required for Protection of Latently Epstein-Barr Virus-Infected B Cells against Specific Apoptotic Stimuli

2004 ◽  
Vol 78 (22) ◽  
pp. 12694-12697 ◽  
Author(s):  
Jae Myun Lee ◽  
Kyoung-Ho Lee ◽  
Christopher J. Farrell ◽  
Paul D. Ling ◽  
Bettina Kempkes ◽  
...  
Keyword(s):  
B Cells ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Epstein Barr Virus ◽  
Necrosis Factor Alpha ◽  
Barr Virus ◽  
Factor Alpha ◽  
Epstein Barr ◽  
Necrosis Factor ◽  
Transcriptional Transactivator

ABSTRACT In addition to functioning as a transcriptional transactivator, Epstein-Barr virus EBNA2 interacts with Nur77 to protect against Nur77-mediated apoptosis. Estrogen-regulated EBNA2 in EREB2-5 cells was replaced by either EBNA2 or EBNA2 with a deletion of conserved region 4 (EBNA2ΔCR4). Both EBNA2-converted and EBNA2ΔCR4-converted EREB2-5 cells grew in the absence of estrogen and expressed LMP1. Treatment with tumor necrosis factor alpha did not induce apoptosis of EBNA2- or EBNA2ΔCR4-expressing cells, but EBNA2ΔCR4 cells were susceptible to etoposide and 5-fluorouracil, Nur77-mediated inducers of apoptosis. Thus, EBNA2 protects B cells against specific apoptotic agents against which LMP1 is not effective.

scholarly journals Epstein-Barr Virus Immediate-Early Protein BZLF1 Inhibits Tumor Necrosis Factor Alpha-Induced Signaling and Apoptosis by Downregulating Tumor Necrosis Factor Receptor 1

2004 ◽  
Vol 78 (1) ◽  
pp. 544-549 ◽  
Author(s):  
Thomas E. Morrison ◽  
Amy Mauser ◽  
Aloysius Klingelhutz ◽  
Shannon C. Kenney
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Epstein Barr Virus ◽  
Necrosis Factor Alpha ◽  
Barr Virus ◽  
Early Protein ◽  
Tnf Α ◽  
Factor Alpha ◽  
Epstein Barr ◽  
Necrosis Factor

ABSTRACT Tumor necrosis factor alpha (TNF-α) is a key mediator of host immune and inflammatory responses and inhibits herpesvirus replication by cytolytic and noncytolytic mechanisms. TNF-α effects are primarily mediated through the major TNF-α receptor, TNF-R1, which is constitutively expressed in most cell types. Here we show that the Epstein-Barr virus (EBV) immediate-early protein BZLF1 prevents TNF-α activation of target genes and TNF-α-induced cell death. These effects are mediated by down-regulation of the promoter for TNF-R1. Additionally, we demonstrate that expression of TNF-R1 is downregulated during the EBV lytic replication cycle. Thus, EBV has developed a novel mechanism for evading TNF-α antiviral effects during lytic reactivation or primary infection.

Mitigation of tumor necrosis factor alpha cytotoxicity by aurintricarboxylic acid in human peripheral B lymphocytes

2003 ◽  
Vol 66 (10) ◽  
pp. 1973-1979 ◽  
Author(s):  
Marco Marchisio ◽  
Federica Brugnoli ◽  
Eugenio Santavenere ◽  
Maya Paludi ◽  
Fausta Ciccocioppo ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
B Lymphocytes ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Aurintricarboxylic Acid ◽  
Factor Alpha ◽  
Necrosis Factor
Sign in / Sign up

Export Citation Format

Share Document