scholarly journals LAR Receptor Tyrosine Phosphatases and HSPGs Guide Peripheral Sensory Axons to the Skin

2012 ◽  
Vol 22 (5) ◽  
pp. 373-382 ◽  
Author(s):  
Fang Wang ◽  
Sean N. Wolfson ◽  
Arash Gharib ◽  
Alvaro Sagasti
Keyword(s):  
Tyrosine Phosphatases ◽  
Sensory Axons ◽  
Receptor Tyrosine Phosphatases ◽  
Peripheral Sensory

scholarly journals Homophilic interactions mediated by receptor tyrosine phosphatases μ and κ. A critical role for the novel extracellular MAM domain.

1995 ◽  
Vol 270 (41) ◽  
pp. 24621
Author(s):  
Gerben C.M. Zondag ◽  
Gregory M. Koningstein ◽  
Ying-Ping Jiang ◽  
Jan Sap ◽  
Wouter H. Moolenaar ◽  
...  
Keyword(s):  
Critical Role ◽  
The Novel ◽  
Tyrosine Phosphatases ◽  
Receptor Tyrosine Phosphatases

scholarly journals Aberrant plasticity of peripheral sensory axons in a painful neuropathy

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Takashi Hirai ◽  
Yatendra Mulpuri ◽  
Yanbing Cheng ◽  
Zheng Xia ◽  
Wei Li ◽  
...  
Keyword(s):  
Painful Neuropathy ◽  
Sensory Axons ◽  
Peripheral Sensory

scholarly journals Receptor Tyrosine Phosphatases Are Required for Motor Axon Guidance in the Drosophila Embryo

Cell ◽  
1996 ◽  
Vol 84 (4) ◽  
pp. 599-609 ◽  
Author(s):  
Chand J Desai ◽  
Joseph G Gindhart ◽  
Lawrence S.B Goldstein ◽  
Kai Zinn
Keyword(s):  
Axon Guidance ◽  
Motor Axon ◽  
Drosophila Embryo ◽  
Tyrosine Phosphatases ◽  
Receptor Tyrosine Phosphatases

scholarly journals Homophilic Interactions Mediated by Receptor Tyrosine Phosphatases μ and κ. A CRITICAL ROLE FOR THE NOVEL EXTRACELLULAR MAM DOMAIN

1995 ◽  
Vol 270 (24) ◽  
pp. 14247-14250 ◽  
Author(s):  
Gerben C. M. Zondag ◽  
Gregory M. Koningstein ◽  
Ying-Ping Jiang ◽  
Jan Sap ◽  
Wouter H. Moolenaar ◽  
...  
Keyword(s):  
Critical Role ◽  
The Novel ◽  
Tyrosine Phosphatases ◽  
Receptor Tyrosine Phosphatases

scholarly journals Competition and cooperation among receptor tyrosine phosphatases control motoneuron growth cone guidance in Drosophila

Development ◽  
1997 ◽  
Vol 124 (10) ◽  
pp. 1941-1952 ◽  
Author(s):  
C.J. Desai ◽  
N.X. Krueger ◽  
H. Saito ◽  
K. Zinn
Keyword(s):  
Growth Cone ◽  
Drosophila Embryo ◽  
Tyrosine Phosphatases ◽  
Intermediate Target ◽  
Terminal Arbor ◽  
Cellular Context ◽  
The Common ◽  
Receptor Tyrosine Phosphatases ◽  
Partial Redundancy ◽  
Growth Cone Guidance

The neural receptor tyrosine phosphatases DPTP69D, DPTP99A and DLAR are involved in motor axon guidance in the Drosophila embryo. Here we analyze the requirements for these three phosphatases in growth cone guidance decisions along the ISN and SNb motor pathways. Any one of the three suffices for the progression of ISN pioneer growth cones beyond their first intermediate target in the dorsal muscle field. DLAR or DPTP69D can facilitate outgrowth beyond a second intermediate target, and DLAR is uniquely required for formation of a normal terminal arbor. A different pattern of partial redundancy among the three phosphatases is observed for the SNb pathway. Any one of the three suffices to allow SNb axons to leave the common ISN pathway at the exit junction. When DLAR is not expressed, however, SNb axons sometimes bypass their ventrolateral muscle targets after leaving the common pathway, instead growing out as a separate bundle adjacent to the ISN. This abnormal guidance decision can be completely suppressed by also removing DPTP99A, suggesting that DLAR turns off or counteracts a DPTP99A signal that favors the bypass axon trajectory. Our results show that the relationships among the tyrosine phosphatases are complex and dependent on cellular context. At growth cone choice points along one nerve, two phosphatases cooperate, while along another nerve these same phosphatases can act in opposition to one another.

Complex Genetic Interactions among Four Receptor Tyrosine Phosphatases Regulate Axon Guidance in Drosophila

2001 ◽  
Vol 17 (2) ◽  
pp. 274-291 ◽  
Author(s):  
Qi Sun ◽  
Benno Schindelholz ◽  
Matthias Knirr ◽  
Aloisia Schmid ◽  
Kai Zinn
Keyword(s):  
Axon Guidance ◽  
Genetic Interactions ◽  
Tyrosine Phosphatases ◽  
Receptor Tyrosine Phosphatases

scholarly journals A Segmental Chronic Pain Syndrome in Rats Associated with Intrathecal Infusion of NMDA: evidence for selective action in the dorsal horn

1994 ◽  
Vol 21 (1) ◽  
pp. 24-28 ◽  
Author(s):  
Douglas W. Zochodne ◽  
Marilyn Murray ◽  
Sukriti Nag ◽  
Richard J. Riopelle
Keyword(s):  
Magnesium Sulfate ◽  
Experimental Pain ◽  
Pain Syndrome ◽  
Sprague Dawley ◽  
Sensory Axons ◽  
Sprague Dawley Rats ◽  
Peripheral Sensory ◽  
Excessive Grooming ◽  
Phosphate Buffered Saline ◽  
Intrathecal Infusion

ABSTRACT:We explored the effects of chronic lumbar intrathecal NMDA infusion (mini-osmotic pumps) in Sprague-Dawley rats on motor and sensory axon integrity. Several different infusion protocols, each given over a 4 week period were examined: 0.15 M NMDA in phosphate buffered saline; phosphate buffered saline without NMDA; and 0.20 M magnesium sulfate plus 0.15 M NMDA; 0.35 M NMDA. In two additional protocols, 0.15 M NMDA or phosphate buffered saline were infused for a total of 8 weeks. Within 1-2 weeks of the onset of NMDA, but not phosphate buffered saline infusions, the rats exhibited irritability, circling, biting and excessive grooming resulting in loss of hair, and skin ulcerations from autotomy localized to lumbar and sacral innervated dermatomes. Co-infusion of NMDA with magnesium sulfate almost completely prevented these findings. The behavioural changes were not associated with abnormalities of sensory or motor conduction. Intrathecal infusion of NMDA induces a chronic “central” experimental pain disorder in rats, localized to the cord segment with the greatest exposure to the infusion, without involvement of peripheral sensory axons and sparing the axonal integrity of anterior horn cells.

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