scholarly journals A Genome-wide SNP Genotyping Array Reveals Patterns of Global and Repeated Species-Pair Divergence in Sticklebacks

2012 ◽  
Vol 22 (1) ◽  
pp. 83-90 ◽  
Author(s):  
Felicity C. Jones ◽  
Yingguang Frank Chan ◽  
Jeremy Schmutz ◽  
Jane Grimwood ◽  
Shannon D. Brady ◽  
...  
Keyword(s):  
Snp Genotyping ◽  
Species Pair ◽  
Genotyping Array ◽  
Genome Wide ◽  
A Genome

Genome-wide mapping of copy number variations in commercial hybrid pigs using a high-density SNP genotyping array

2016 ◽  
Vol 52 (1) ◽  
pp. 85-92 ◽  
Author(s):  
L. S. Zhou ◽  
J. Li ◽  
J. Yang ◽  
C. L. Liu ◽  
X. H. Xie ◽  
...  
Keyword(s):  
Copy Number ◽  
Copy Number Variations ◽  
High Density ◽  
Snp Genotyping ◽  
Genotyping Array ◽  
Genome Wide

scholarly journals Targeting 160 Candidate Genes for Blood Pressure Regulation with a Genome-Wide Genotyping Array

PLoS ONE ◽  
2009 ◽  
Vol 4 (6) ◽  
pp. e6034 ◽  
Author(s):  
Siim Sõber ◽  
Elin Org ◽  
Katrin Kepp ◽  
Peeter Juhanson ◽  
Susana Eyheramendy ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Candidate Genes ◽  
Blood Pressure Regulation ◽  
Pressure Regulation ◽  
Genotyping Array ◽  
Genome Wide ◽  
A Genome

scholarly journals Genetic background of ataxia in children younger than 5 years in Finland

2020 ◽  
Vol 6 (4) ◽  
pp. e444
Author(s):  
Erika Ignatius ◽  
Pirjo Isohanni ◽  
Max Pohjanpelto ◽  
Päivi Lahermo ◽  
Simo Ojanen ◽  
...  
Keyword(s):  
Exome Sequencing ◽  
Molecular Diagnosis ◽  
Genetic Background ◽  
De Novo ◽  
Substantial Contribution ◽  
Considerable Proportion ◽  
Genotyping Array ◽  
Genome Wide ◽  
A Genome ◽  
Tertiary Center

ObjectiveTo characterize the genetic background of molecularly undefined childhood-onset ataxias in Finland.MethodsThis study examined a cohort of patients from 50 families with onset of an ataxia syndrome before the age of 5 years collected from a single tertiary center, drawing on the advantages offered by next generation sequencing. A genome-wide genotyping array (Illumina Infinium Global Screening Array MD-24 v.2.0) was used to search for copy number variation undetectable by exome sequencing.ResultsExome sequencing led to a molecular diagnosis for 20 probands (40%). In the 23 patients examined with a genome-wide genotyping array, 2 additional diagnoses were made. A considerable proportion of probands with a molecular diagnosis had de novo pathogenic variants (45%). In addition, the study identified a de novo variant in a gene not previously linked to ataxia: MED23. Patients in the cohort had medically actionable findings.ConclusionsThere is a high heterogeneity of causative mutations in this cohort despite the defined age at onset, phenotypical overlap between patients, the founder effect, and genetic isolation in the Finnish population. The findings reflect the heterogeneous genetic background of ataxia seen worldwide and the substantial contribution of de novo variants underlying childhood ataxia.

scholarly journals Detecting genetic regions associated with height in the native ponies of the British Isles by using high density SNP genotyping

Genome ◽  
2018 ◽  
Vol 61 (10) ◽  
pp. 767-770 ◽  
Author(s):  
Ilze Skujina ◽  
Clare L. Winton ◽  
Matthew J. Hegarty ◽  
Robert McMahon ◽  
Deborah M. Nash ◽  
...  
Keyword(s):  
Genetic Control ◽  
Significant Snps ◽  
High Density ◽  
Snp Genotyping ◽  
Analysis Approach ◽  
British Isles ◽  
Genome Wide Analysis ◽  
Genome Wide ◽  
A Genome ◽  
Equine Industry

Height is an important characteristic in the equine industry although little is known about its genetic control in native British breeds of ponies. This study aimed to map QTL data with the withers height in four pony breeds native to the British Isles, including two different sections within Welsh Cobs. In this study, a genome-wide analysis approach using the Illumina EquineSNP50 Infinium BeadChip was applied to 105 ponies and cobs. Analysis identified 222 highly significant height-associated SNPs (P ≤ 10−5), among which three SNPs on ECA9 have also been previously reported elsewhere. The highest number of significant SNPs associated to height in the native British horses were located on ECA1, ECA8, and ECA16.

scholarly journals Genome-Wide SNP-Genotyping Array to Study the Evolution of the Human Pathogen Vibrio vulnificus Biotype 3

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e114576 ◽  
Author(s):  
Nili Raz ◽  
Yael Danin-Poleg ◽  
Ryan B. Hayman ◽  
Yudi Bar-On ◽  
Alex Linetsky ◽  
...  
Keyword(s):  
Vibrio Vulnificus ◽  
Snp Genotyping ◽  
Human Pathogen ◽  
Genotyping Array ◽  
Genome Wide

scholarly journals A Genome-Wide Association Study Using a Custom Genotyping Array Identifies Variants inGPR158Associated With Reduced Energy Expenditure in American Indians

Diabetes ◽  
2017 ◽  
Vol 66 (8) ◽  
pp. 2284-2295 ◽  
Author(s):  
Paolo Piaggi ◽  
Ivica Masindova ◽  
Yunhua L. Muller ◽  
Josep Mercader ◽  
Gregory B. Wiessner ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Association Study ◽  
American Indians ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genotyping Array ◽  
Genome Wide ◽  
A Genome

scholarly journals A sex-stratified genome-wide association study of tuberculosis using a multi-ethnic genotyping array

2018 ◽  
Author(s):  
Haiko Schurz ◽  
Craig J Kinnear ◽  
Chris Gignoux ◽  
Genevieve Wojcik ◽  
Paul D van Helden ◽  
...  
Keyword(s):  
Association Study ◽  
X Chromosome ◽  
Complex Disease ◽  
Genome Wide Association Study ◽  
Interaction Analysis ◽  
Genome Wide Association ◽  
Genotyping Array ◽  
Association Testing ◽  
Genome Wide ◽  
A Genome

AbstractTuberculosis (TB), caused by Mycobacterium tuberculosis, is a complex disease with a known human genetic component. Males seem to be more affected than females and in most countries the TB notification rate is twice as high in males as in females. While socio-economic status, behaviour and sex hormones influence the male bias they do not fully account for it. Males have only one copy of the X chromosome, while diploid females are subject to X chromosome inactivation. In addition, the X chromosome codes for many immune-related genes, supporting the hypothesis that X-linked genes could contribute to TB susceptibility in a sex-biased manner. We report the first TB susceptibility genome-wide association study (GWAS) with a specific focus on sex-stratified autosomal analysis and the X chromosome. Individuals from an admixed South African population were genotyped using the Illumina Multi Ethnic Genotyping Array, specifically designed as a suitable platform for diverse and admixed populations. Association testing was done on the autosome and X chromosome in a sex stratified and combined manner. SNP association testing was not statistically significant using a stringent cut-off for significance but revealed likely candidate genes that warrant further investigation. A genome wide interaction analysis detected 16 significant interactions. Finally, the results highlight the importance of sex-stratified analysis as strong sex-specific effects were identified on both the autosome and X chromosome.

A genome-wide detection of copy number variation using SNP genotyping arrays in Beijing-You chickens

Genetica ◽  
2014 ◽  
Vol 142 (5) ◽  
pp. 441-450 ◽  
Author(s):  
Wei Zhou ◽  
Ranran Liu ◽  
Jingjing Zhang ◽  
Maiqing Zheng ◽  
Peng Li ◽  
...  
Keyword(s):  
Copy Number Variation ◽  
Copy Number ◽  
Snp Genotyping ◽  
Genome Wide ◽  
A Genome ◽  
Number Variation
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