scholarly journals The Tumor-Suppressor Gene fat Controls Tissue Growth Upstream of Expanded in the Hippo Signaling Pathway

2006 ◽  
Vol 16 (21) ◽  
pp. 2081-2089 ◽  
Author(s):  
Elizabeth Silva ◽  
Yonit Tsatskis ◽  
Laura Gardano ◽  
Nic Tapon ◽  
Helen McNeill
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Signaling Pathway ◽  
Suppressor Gene ◽  
Tissue Growth ◽  
Hippo Signaling ◽  
Hippo Signaling Pathway

ALEX1, a novel tumor suppressor gene, inhibits gastric cancer metastasis via the PAR-1/Rho GTPase signaling pathway

2017 ◽  
Vol 53 (1) ◽  
pp. 71-83 ◽  
Author(s):  
Li Pang ◽  
Jian-fang Li ◽  
Liping Su ◽  
Mingde Zang ◽  
Zhiyuan Fan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Signaling Pathway ◽  
Cancer Metastasis ◽  
Rho Gtpase ◽  
Suppressor Gene

scholarly journals MIR502 Acts As a Tumor Suppressor Gene to Accelerate Apoptosis and Suppress Proliferation by Targeting Hippo Signaling Pathway in Ovarian Cancer

2020 ◽  
Author(s):  
Yan Li ◽  
Qi Wang ◽  
Ning Ning ◽  
Fanglan Tang ◽  
Yan Wang
Keyword(s):  
Ovarian Cancer ◽  
Signaling Pathway ◽  
Kegg Pathway ◽  
Enrichment Analysis ◽  
Suppressor Gene ◽  
Hippo Signaling ◽  
Ppi Network ◽  
Pathway Enrichment ◽  
Hippo Signaling Pathway ◽  
Upstream Regulator

Abstract Background Ovarian cancer (OC) is the major cause of death among women due to the lack of early screening methods and complex pathological progression. Increasing evidence indicated that microRNAs were considered as gene expression regulators in tumors by interacting with mRNAs. Although researches regarding with OC and microRNAs are extensive, the vital role of MIR502 in OC still remains unclear.Methods We integrated two microRNA expression arrays from GEO to identify differentially expressed genes. Kaplan–Meier method was used to screen miRNAs that had influence on survival outcome. Upstream regulator of MIR502 was predicted by JASPAR and verified by ChIP-seq data. The LinkedOmics database was used to study correlated genes with MIR502. Gene Set Enrichment Analysis (GSEA) was conducted to reveal the functional annotation of GO and KEGG pathway enrichment analysis by using the open access WebGestalt tool. We constructed PPI network by using the STRING to further explore core protein.Results We found that expression level of MIR502 was significantly down regulated in OC, which was related to poor overall survival outcome. NRF1 as the upstream regulator of MIR502 was predicted by JASPAR and verified by ChIP-seq data. In addition, anti-apoptosis and pro-proliferation genes attending in Hippo signaling pathway, including CCND1, MYC, FGF1 and GLI2 were negatively regulated by MIR502 in the analysis of GO and KEGG pathway enrichment results. PPI network further demonstrated that CCND1 and MYCN were at core position in the development of ovarian cancer.Conclusions MIR502, which was regulated by NRF1, acted as a tumor suppressor gene to accelerate apoptosis and suppress proliferation by targeting Hippo signaling pathway in ovarian cancer.

scholarly journals Regulation of carcinogenesis and modulation through Wnt/β-catenin signaling by curcumin in an ovarian cancer cell line

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Hsing-Yu Yen ◽  
Chih-Wei Tsao ◽  
Ya-Wen Lin ◽  
Chih-Chi Kuo ◽  
Chang-Huei Tsao ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumor Suppressor ◽  
Cell Line ◽  
Tumor Suppressor Gene ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Ovarian Cancer Cell Line ◽  
Cancer Cell Line ◽  
Suppressor Gene

AbstractThe secreted frizzled-related protein 5 gene (SFRP5) that antagonize the Wnt/β-catenin signaling is frequently inactivated by promoter methylation and oncogenic activation of the Wnt signaling pathway is common in many cancers. The curcumin-rich Curcuma longa has been reported to potent anti-cancer property involved in epigenetic regulation to inhibit tumor suppressor gene methylation and re-expression. In a compounds screening, we found that curcumin can inhibit Wnt/β-catenin signaling. Therefore, the aim of this study was to investigate the effects of curcumin on SFRP5 DNA methylation modification in an ovarian cancer cell line (SKOV3). SKOV3 cells were treated with DMSO, 10 μM 5-aza-2′-deoxycytidine (DAC), 5 μM DAC, 20 μM curcumin, and 20 μM curcumin combined with 5 μM DAC for 96 hours, following which RNA and proteins were extracted for further analysis. The results showed that curcumin combined with 5 μM DAC may inhibit cancer cell colony formation, migration through EMT (epithelial–mesenchymal transition) process regulation, total DNMT activity, especially in DNMT3a protein expression, and may also regulate tumor suppressor gene SFRP5 expression involved in the Wnt/β-catenin signaling pathway. The combined treatment attenuated ovarian cancer development.

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