Updated use of TACE for hepatocellular carcinoma treatment: How and when to use it based on clinical evidence

2019 ◽  
Vol 72 ◽  
pp. 28-36 ◽  
Author(s):  
Jean-Luc Raoul ◽  
Alejandro Forner ◽  
Luigi Bolondi ◽  
Tan To Cheung ◽  
Roman Kloeckner ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Evidence

scholarly journals Beyond the Usual Suspects: Hepatitis E Virus and Its Implications in Hepatocellular Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5867
Author(s):  
Mara Klöhn ◽  
Jil Alexandra Schrader ◽  
Yannick Brüggemann ◽  
Daniel Todt ◽  
Eike Steinmann
Keyword(s):  
Hepatocellular Carcinoma ◽  
Viral Hepatitis ◽  
Hepatitis E Virus ◽  
Clinical Evidence ◽  
Hepatitis E ◽  
Clinical Spectrum ◽  
Immunocompromised Patients ◽  
Virus Infections ◽  
The Relationship ◽  
Liver Infection

Hepatitis E virus infections are the leading cause of viral hepatitis in humans, contributing to an estimated 3.3 million symptomatic cases and almost 44,000 deaths annually. Recently, HEV infections have been found to result in chronic liver infection and cirrhosis in severely immunocompromised patients, suggesting the possibility of HEV-induced hepatocarcinogenesis. While HEV-associated formation of HCC has rarely been reported, the expansion of HEV’s clinical spectrum and the increasing evidence of chronic HEV infections raise questions about the connection between HEV and HCC. The present review summarizes current clinical evidence of the relationship between HEV and HCC and discusses mechanisms of virus-induced HCC development with regard to HEV pathogenesis. We further elucidate why the development of HEV-induced hepatocellular carcinoma has so rarely been observed and provide an outlook on possible experimental set-ups to study the relationship between HEV and HCC formation.

scholarly journals Hepatocellular Carcinoma Immunopathogenesis: Clinical Evidence for Global T Cell Defects and an Immunomodulatory Role for Soluble CD25 (sCD25)

2009 ◽  
Vol 55 (2) ◽  
pp. 484-495 ◽  
Author(s):  
Roniel Cabrera ◽  
Miguel Ararat ◽  
Mengde Cao ◽  
Yiling Xu ◽  
Clive Wasserfall ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
T Cell ◽  
Clinical Evidence ◽  
Soluble Cd25

scholarly journals Hepatic resection for hepatocellular carcinoma in patients with Child–Pugh's A cirrhosis: is clinical evidence of portal hypertension a contraindication?

HPB ◽  
2013 ◽  
Vol 15 (1) ◽  
pp. 78-84 ◽  
Author(s):  
Roberto Santambrogio ◽  
Michael D. Kluger ◽  
Mara Costa ◽  
Andrea Belli ◽  
Matteo Barabino ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Portal Hypertension ◽  
Hepatic Resection ◽  
Clinical Evidence

scholarly journals DNA Hypermethylation Modification Promotes the Development of Hepatocellular Carcinoma by Depressing the Tumor Suppressor Gene ZNF334

2021 ◽  
Author(s):  
Da-peng Sun ◽  
Xiao-jie Gan ◽  
Lei Liu ◽  
Yuan Yang ◽  
Dong-yang Ding ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Methylation ◽  
Tumor Suppressor ◽  
Liver Cancer ◽  
Tumor Suppressor Gene ◽  
Clinical Evidence ◽  
Early Stage ◽  
Suppressor Gene ◽  
Dna Hypermethylation ◽  
Dysplastic Nodules

Abstract Background: DNA methylation plays a pivotal role in the development and progression of tumors, but studies focused on the dynamic changes of DNA methylation in the development of hepatocellular carcinoma (HCC) are rare. This manuscript is aimed to construct pre- and early DNA methylation maps of liver cancer of the same genetic background, as well as to reveal the mechanism of epigenetics regulating gene expression during the development of liver cancer, thus providing new targets and clinical evidence for early diagnosis and shedding lights on the precise treatment for liver cancer. Methods: The study includes 5 patients who were chronic hepatitis B virus infected, clinically diagnosed as primary liver cancer and pathologically diagnosed as early liver cancer with liver dysplastic nodules. Liver fibrosis tissues, dysplastic nodules and early HCC tissues from these patients have been used to measure DNA methylation. Results: We report significant differences in the DNA methylation spectrum of three types of tissues. In the early stage of HCC, DNA hypermethylation of tumor suppressor genes is predominant. Additionally, DNA hypermethylation in the early stage of HCC changes the binding of transcription factor P53 to the promoter of tumor suppressor gene ZNF334, and inhibits the expression of ZNF334 at the transcription level. Furthermore, through a series of in vivo and in vitro experiments, we have clarified the exacerbation effect of tumor suppressor gene ZNF334 deletion in the occurrence of HCC. Combined with clinical data, we found that the overall survival and disease-free survival of patients with high ZNF334 expression are longer than the lower one. Conclusions: We constructed a sequential map of DNA methylation modification during the occurrence of HCC, and clarified the biological function and regulatory mechanism of the tumor suppressor gene ZNF334, which is regulated by related DNA methylation sites, and also provide new targets and clinical evidence for the early diagnosis and precise treatment of liver cancer.

scholarly journals Activation of c-Jun predicts a poor response to sorafenib in hepatocellular carcinoma: Preliminary Clinical Evidence

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Wei Chen ◽  
Weikai Xiao ◽  
Kunsong Zhang ◽  
Xiaoyu Yin ◽  
Jiaming Lai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Evidence ◽  
Poor Response

scholarly journals Therapy of Intermediate-Stage Hepatocellular Carcinoma: Current Evidence and Clinical Practice

2020 ◽  
Vol 37 (05) ◽  
pp. 456-465
Author(s):  
Nathan X. Chai ◽  
Julius Chapiro
Keyword(s):  
Hepatocellular Carcinoma ◽  
Thermal Ablation ◽  
Clinical Evidence ◽  
Checkpoint Inhibitors ◽  
Intermediate Stage ◽  
Locoregional Therapy ◽  
Current Evidence ◽  
Locoregional Treatment ◽  
Wide Range ◽  
Bland Embolization

AbstractIntermediate-stage Hepatocellular Carcinoma (HCC) represents a wide range of disease burden. Patients with different levels of liver function, tumor size, and number of lesions may all have intermediate-stage disease according to the Barcelona Clinic Liver Cancer (BCLC) staging system. Several minimally invasive image-guided locoregional therapies are available for the treatment of intermediate-stage HCC, including conventional transarterial chemoembolization (cTACE), drug-eluting bead TACE (DEB-TACE), yttrium-90 radioembolization (Y-90 RE), thermal ablation, bland embolization, and combination therapy. Available clinical evidence points to cTACE as the current gold standard for the locoregional treatment of intermediate-stage HCC. DEB-TACE is at best non-inferior to cTACE in terms of survival benefit. Y-90 RE is a maturing therapy, and some institutions have adopted it as first-line therapy for intermediate-stage HCC. Thermal ablation combined with TACE may be used in select patients, while bland embolization has only limited evidence for its use. The combination of locoregional therapy with VEGF inhibitors or immune checkpoint inhibitors has also been explored. This article will examine in detail the clinical evidence supporting available locoregional treatment options for intermediate-stage HCC.

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