The role of the tumor-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets

2014 ◽  
Vol 40 (4) ◽  
pp. 558-566 ◽  
Author(s):  
Steven L. Wood ◽  
Maria Pernemalm ◽  
Philip A. Crosbie ◽  
Anthony D. Whetton
Keyword(s):  
Lung Cancer ◽  
Tumor Microenvironment ◽  
Cancer Metastasis ◽  
Therapeutic Targets ◽  
Lung Cancer Metastasis

scholarly journals The role of exosomes in lung cancer metastasis and clinical applications: an updated review

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Lei Yin ◽  
Xiaotian Liu ◽  
Xuejun Shao ◽  
Tao Feng ◽  
Jun Xu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Cancer Cell ◽  
Cancer Metastasis ◽  
Value Assessment ◽  
Lung Carcinogenesis ◽  
Research Attention ◽  
Mesenchymal Transition ◽  
Lung Cancer Metastasis

AbstractLung cancer is the leading cause of cancer-associated deaths accounting for 24% of all cancer deaths. As a crucial phase of tumor progression, lung cancer metastasis is linked to over 70% of these mortalities. In recent years, exosomes have received increasing research attention in their role in the induction of carcinogenesis and metastasis in the lung. In this review, recent studies on the contribution of exosomes to lung cancer metastasis are discussed, particularly highlighting the role of lung tumor-derived exosomes in immune system evasion, epithelial-mesenchymal transition, and angiogenesis, and their involvement at both the pre-metastatic and metastatic phases. The clinical application of exosomes as therapeutic drug carriers, their role in antitumor drug resistance, and their utility as predictive biomarkers in diagnosis and prognosis are also presented. The metastatic activity, a complex multistep process of cancer cell invasion, survival in blood vessels, attachment and subsequent colonization of the host's organs, is integrated with exosomal effects. Exosomes act as functional mediating factors in cell–cell communication, influencing various steps of the metastatic cascade. To this end, lung cancer cell-derived exosomes enhance cell proliferation, angiogenesis, and metastasis, regulate drug resistance, and antitumor immune activities during lung carcinogenesis, and are currently being explored as an important component in liquid biopsy assessment for diagnosing lung cancer. These nano-sized extracellular vesicles are also being explored as delivery vehicles for therapeutic molecules owing to their unique properties of biocompatibility, circulatory stability, decreased toxicity, and tumor specificity. The current knowledge of the role of exosomes highlights an array of exosome-dependent pathways and cargoes that are ripe for exploiting therapeutic targets to treat lung cancer metastasis, and for predictive value assessment in diagnosis, prognosis, and anti-tumor drug resistance.

Abstract 2290: More than a biomarker: Studying the role of vimentin in lung cancer metastasis

2015 ◽  
Author(s):  
Alessandra M. Salgueiro ◽  
Melissa Gilbert-Ross ◽  
Lauren S. Havel ◽  
John Shupe ◽  
Adam I. Marcus
Keyword(s):  
Lung Cancer ◽  
Cancer Metastasis ◽  
Lung Cancer Metastasis

scholarly journals Deficiency of Functional Iron-Sulfur Domains in ABCE1 Inhibits the Proliferation and Migration of Lung Adenocarcinomas By Regulating the Biogenesis of Beta-Actin In Vitro

2017 ◽  
Vol 44 (2) ◽  
pp. 554-566 ◽  
Author(s):  
Qian Yu ◽  
Xu Han ◽  
Da-Li Tian
Keyword(s):  
Lung Cancer ◽  
Cancer Metastasis ◽  
A549 Cells ◽  
Metastatic Progression ◽  
Lung Cancer Metastasis ◽  
And Migration ◽  
Opposing Effects ◽  
Proliferation And Migration

Background/Aims: ATP-binding cassette transporter E1 (ABCE1), a unique ABC superfamily member that bears two Fe-S clusters, is essential for metastatic progression in lung cancer. Fe-S clusters within ABCE1 are crucial for ribosome dissociation and translation reinitiation; however, whether these clusters promote tumor proliferation and migration is unclear. Methods: The interaction between ABCE1 and β-actin was confirmed using GST pull-down. The lung adenocarcinoma (LUAD) cell line A549 was transduced with lentiviral packaging vectors overexpressing either wild-type ABCE1 or ABCE1 with Fe-S cluster deletions (ΔABCE1). The role of Fe-S clusters in the viability and migration of cancer cells was evaluated using clonogenic, MTT, Transwell and wound healing assays. Cytoskeletal rearrangement was determined using immunofluorescent techniques. Results: Fe-S clusters were the key domains in ABCE1 involved in binding to β-actin. The proliferative and migratory capacity increased in cells overexpressing ABCE1. However, the absence of Fe-S clusters reversed these effects. A549 cells overexpressing ABCE1 exhibited irregular morphology and increased levels of cytoskeletal polymerization as indicated by the immunofluorescence images. In contrast, cells expressing the Fe-S cluster deletion mutant presented opposing effects. Conclusion: These results demonstrate the indispensable role of Fe-S clusters when ABCE1 participates in the proliferation and migration of LUADs by interacting with β-actin. The Fe-S clusters of ABCE1 may be potential targets for the prevention of lung cancer metastasis.

scholarly journals Abstract 4904: GLUT4 exhibits a non-canonical role of regulating lung cancer metastasis

2017 ◽  
Author(s):  
Changyong Wei ◽  
Abhinav Achreja ◽  
Jessica Konen ◽  
Gabriel Sica ◽  
Melissa Gilbert-Ross ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Metastasis ◽  
Lung Cancer Metastasis

Abstract 3976: The role of a novel oncomiR, miR-135b, in lung cancer metastasis and clinical application

2011 ◽  
Author(s):  
Ching-Wen Lin ◽  
Jau-Chen Lin ◽  
Yih-Leong Chang ◽  
Hsuan-Yu Chen ◽  
Szu-Hua Pan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Clinical Application ◽  
Cancer Metastasis ◽  
Lung Cancer Metastasis

Use of bioluminescent imaging to investigate the role of nuclear factor-κΒ in experimental non-small cell lung cancer metastasis

2007 ◽  
Vol 25 (1) ◽  
pp. 43-51 ◽  
Author(s):  
Georgios T. Stathopoulos ◽  
Taylor P. Sherrill ◽  
Wei Han ◽  
Ruxana T. Sadikot ◽  
Vasiliy V. Polosukhin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Cancer Metastasis ◽  
Small Cell ◽  
Bioluminescent Imaging ◽  
Nuclear Factor ◽  
Small Cell Lung ◽  
Lung Cancer Metastasis

scholarly journals MiR-7/TGF-beta2 axis sustains acidic tumor microenvironment-induced lung cancer metastasis

2021 ◽  
Author(s):  
Tao Su ◽  
Suchao Huang ◽  
Yanmin Zhang ◽  
Yajuan Guo ◽  
Shuwei Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Microenvironment ◽  
Cancer Metastasis ◽  
Lung Cancer Metastasis

Wound Healing after Trauma May Predispose to Lung Cancer Metastasis

2011 ◽  
Vol 44 (5) ◽  
pp. 591-596 ◽  
Author(s):  
Nicholas D. Walter ◽  
Pamela L. Rice ◽  
Elizabeth F. Redente ◽  
Emily F. Kauvar ◽  
Lisa Lemond ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Wound Healing ◽  
Cancer Metastasis ◽  
Lung Cancer Metastasis
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