Isolated limb perfusion of soft tissue sarcomas: A comprehensive review of literature

2013 ◽  
Vol 39 (6) ◽  
pp. 569-577 ◽  
Author(s):  
Jojanneke M. Seinen ◽  
Harald J. Hoekstra
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Isolated Limb Perfusion ◽  
Review Of Literature ◽  
Comprehensive Review ◽  
Limb Perfusion

scholarly journals 18F-FDG PET/MRI for Therapy Response Assessment of Isolated Limb Perfusion in Patients with Soft-Tissue Sarcomas

2019 ◽  
Vol 60 (11) ◽  
pp. 1537-1542 ◽  
Author(s):  
Johannes Grueneisen ◽  
Benedikt Schaarschmidt ◽  
Aydin Demircioglu ◽  
Michal Chodyla ◽  
Ole Martin ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Fdg Pet ◽  
Soft Tissue Sarcomas ◽  
Therapy Response ◽  
Response Assessment ◽  
Isolated Limb Perfusion ◽  
Limb Perfusion ◽  
Therapy Response Assessment ◽  
18F Fdg

Isolated Limb Perfusion in the Treatment of Advanced Soft-tissue Sarcomas

2006 ◽  
pp. 75-84
Author(s):  
Joseph M. Klausner ◽  
Dina Lev-Chelouche ◽  
Isaac Meller ◽  
Moshe Inbar ◽  
Mordechai Gutman
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Isolated Limb Perfusion ◽  
Limb Perfusion

Tumor vascularization and histopathologic regression of soft tissue sarcomas treated with isolated limb perfusion with TNF-α and melphalan

2011 ◽  
Vol 103 (5) ◽  
pp. 371-379 ◽  
Author(s):  
Florian Grabellus ◽  
Corinna Kraft ◽  
Sien-Yi Sheu-Grabellus ◽  
Sebastian Bauer ◽  
Lars E. Podleska ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Isolated Limb Perfusion ◽  
Tumor Vascularization ◽  
Limb Perfusion ◽  
Tnf Α

scholarly journals Histamine combined with melphalan in isolated limb perfusion for the treatment of locally advanced soft tissue sarcomas: preclinical studies in rats

2005 ◽  
Vol 20 (4) ◽  
pp. 275-279 ◽  
Author(s):  
Flavia Brunstein ◽  
Ivan Dunshee de Abranches Oliveira Santos ◽  
Lydia Masako Ferreira ◽  
Sandra T. van Tiel ◽  
Alexander M. M. Eggermont ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Locally Advanced ◽  
Soft Tissue Sarcomas ◽  
Isolated Limb Perfusion ◽  
Brown Norway ◽  
Response Curves ◽  
Limb Perfusion ◽  
Collateral Effects ◽  
Median Diameter ◽  
The Right

PURPOSE: To evaluate the potential benefit of histamine combined with melphalan in the isolated limb perfusion (ILP) as an alternative to TNF-alfa and melphalan combination, for the treatment of irressectable soft tissue sarcomas of the limbs in Brown Norway (BN) rats. METHODS: 20 BN rats had small fragments of syngeneic BN-175 fibosarcoma inserted on the right hind limb. In 7-10 days the tumor reached a median diameter of 12-15 mm and they were randomly divided in four groups (sham, melphalan, histamine and escalating doses of histamine combined to melphalan) being submitted to experimental ILP for 30 minutes. Tumors were measured daily with a caliper and the volume was calculated. RESULTS: Response curves showed a significant effect of the combination of histamine 200 mg/mL with melphalan, with 66% overall response, including 33% complete responses (p< 0.01). There were no systemic collateral effects and locally only mild temporary edema was observed for some animals treated with histamine. CONCLUSION: Histamine combined with melphalan had a promising effect in the ILP warranting future studies to better explore the mechanism of action as well as its potential use in organ perfusion.

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