Regression analysis for the proportional hazards model with parameter constraints under case-cohort design

2018 ◽  
Vol 117 ◽  
pp. 194-206 ◽  
Author(s):  
Lifeng Deng ◽  
Jieli Ding ◽  
Yanyan Liu ◽  
Chengdong Wei
Keyword(s):  
Regression Analysis ◽  
Proportional Hazards ◽  
Proportional Hazards Model ◽  
Cohort Design ◽  
Hazards Model ◽  
Parameter Constraints

scholarly journals Association of Retinal Blood Flow with Progression of Visual Field in Glaucoma

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Soo Ji Jeon ◽  
Da-Young Shin ◽  
Hae-Young Lopilly Park ◽  
Chan Kee Park
Keyword(s):  
Regression Analysis ◽  
Visual Field ◽  
Proportional Hazards ◽  
Proportional Hazards Model ◽  
Open Angle Glaucoma ◽  
Cox Proportional Hazards ◽  
Cox Proportional Hazards Model ◽  
Retinal Blood Flow ◽  
Retrospective Case ◽  
Hazards Model

AbstractIn the glaucoma clinic, patients with normal intraocular pressure (IOP) can sometimes show visual field (VF) progression. Therefore, clarification of relationship between vascular status and glaucomatous VF deterioration is a focus of interest. We used optical coherence tomography angiography (OCTA), with the aim of evaluating the relationship between vessel density (VD) and VF progression in glaucoma patients. We included 104 eyes with open angle glaucoma who were followed up for at least 5 years in this retrospective case-control study. Superficial and deep VD of macula were assessed by OCTA. Regression analysis and Cox proportional hazards model were used to identify factors significantly associated with VF progression. In logistic regression analysis determining VF progression from Guided Progression Analysis (GPA) program, initial IOP and deep macular VD were significantly associated with VF progression in multivariate analysis (P = 0.019 and 0.004). Cox proportional hazards model also identified deep macular VD as significantly related to VF progression (P = 0.035). In conclusion, initial IOP and deep VD were related to VF deterioration in glaucoma. Deep VD might be used as a surrogate of glaucomatous VF progression related with vascular incompetence.

HRA Model for Hypercholesterolemia Based on a Longitudinal Health Database

1998 ◽  
Vol 37 (02) ◽  
pp. 130-133
Author(s):  
T. Kishimoto ◽  
Y. Iida ◽  
K. Yoshida ◽  
M. Miyakawa ◽  
H. Sugimori ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Proportional Hazards ◽  
Proportional Hazards Model ◽  
Model Analysis ◽  
Serum Total Cholesterol ◽  
Hazards Model ◽  
The Mean ◽  
Health Database ◽  
Observation Period

AbstractTo evaluate the risk factors for hypercholesterolemia, we examined 4,371 subjects (3,207 males and 1,164 females) who received medical checkups more than twice at an AMHTS in Tokyo during the period from 1976 through 1991; and whose serum total cholesterol was under 250 mg/dl. The mean follow-up duration was 6.6 years. A self-registering questionnaire was administered at the time of the health checkup. The endpoint of this study was the onset of hypercholesterolemia when the level of serum total cholesterol was 250 mg/dl and over. We compared two prognosis groups (normal and hypercholesterol) in terms of age, examination findings and lifestyle. After assessing each variable, we employed Cox's proportional hazards model analysis to determine the factors related to the occurrence of hypercholesterolemia. According to proportional hazards model analysis, total cholesterol, triglyceride and smoking at the beginning, and hypertension during the observation period were selected in males; and total cholesterol at the beginning and age were selected in females to determine the factors related to the occurrence of hypercholesterolemia.

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