Statistical inference on survival data in group-parallel clinical trials with treatment switching

2013 ◽  
Vol 64 ◽  
pp. 269-280
Author(s):  
Chang Ding ◽  
Siu-keung Tse ◽  
Ronghai Yang
Keyword(s):  
Clinical Trials ◽  
Statistical Inference ◽  
Survival Data ◽  
Treatment Switching

The Effect of Anti-Shock Garments on Prehospital Survival: The Need for Controlled Clinical Trials

1987 ◽  
Vol 3 (1) ◽  
pp. 40-45 ◽  
Author(s):  
Paul E. Pepe ◽  
William H. Bickell ◽  
Kenneth L. Mattox
Keyword(s):  
Clinical Trials ◽  
Survival Data ◽  
Trauma Center ◽  
Present Report ◽  
Early Report ◽  
Medical Personnel ◽  
The United States ◽  
Controlled Clinical Trials ◽  
Initial Field ◽  
Significant Difference

AbstractThere exists strong sentiment, among emergency medical personnel and physicians alike, that the pneumatic anti-shock garment (PASG) “saves lives.” As a result, controlled studies have been criticized as the “withholding of important therapy.” The purpose of this presentation is to confirm the need for controlled clinical trials of the PASG. Despite an early report that the PASG offered no advantage in terms of the presenting emergency center Trauma Score (TS), similar disparagements have continued, particularly because survival data were not discussed. The present report is a pilot analysis of the effect of the PASG on the prehospital survival of patients arriving at an urban trauma center in the United States. In the study, sixty-eight patients were assigned randomly to control and PASG groups in a prospective investigation involving injured patients with systemic hypotension. The 32 control patients, whose mean initial systolic blood pressure (BP) was 59 ± 32 mm Hg, and the 36 PASG-treated patients, whose mean initial BP was 55 ± 31 mm Hg, were found to be well matched for age, sex, type and location of injuries, initial field TS; response, field management, and transport times; and the total amount of intravenous crystalloid infused. The results demonstrated no significant difference between the control and PASG-treated groups in terms of those pronounced dead on arrival at the trauma center (9/32 vs. 10/36). Further studies are therefore justified to determine how the PASG affects the long-term morbidity and mortality of injury victims, particularly those within certain sub-groups such as penetrating abdominal versus those with penetrating thoracic injuries. This report reaffirms the need for early responsible, scientific scrutiny of prehospital interventions.

Statistical inference of adaptive randomized clinical trials for personalized medicine

2015 ◽  
Vol 5 (4) ◽  
pp. 415-425 ◽  
Author(s):  
Feifang Hu ◽  
Yanqing Hu ◽  
Wei Ma ◽  
Lixin Zhang ◽  
Hongjian Zhu
Keyword(s):  
Clinical Trials ◽  
Personalized Medicine ◽  
Statistical Inference ◽  
Randomized Clinical Trials

Statistical inference on censored data for targeted clinical trials under enrichment design

2013 ◽  
Vol 12 (3) ◽  
pp. 165-173 ◽  
Author(s):  
Chen-Fang Chen ◽  
Jr-Rung Lin ◽  
Jen-Pei Liu
Keyword(s):  
Clinical Trials ◽  
Statistical Inference ◽  
Censored Data ◽  
Enrichment Design

scholarly journals Adjusting for Treatment Switching in Clinical Trials When Only Summary Data Are Available – An Evaluation of Potential Methods

2013 ◽  
Vol 16 (7) ◽  
pp. A610-A611 ◽  
Author(s):  
R. Boucher ◽  
K.R. Abrams ◽  
M.J. Crowther ◽  
P.C. Lambert ◽  
A.J. Wailoo ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Treatment Switching ◽  
Potential Methods ◽  
Summary Data

scholarly journals Frailty modelling for survival data from multi-centre clinical trials

2011 ◽  
Vol 30 (17) ◽  
pp. 2144-2159 ◽  
Author(s):  
Il Do Ha ◽  
Richard Sylvester ◽  
Catherine Legrand ◽  
Gilbert MacKenzie
Keyword(s):  
Clinical Trials ◽  
Survival Data

Two-Stage Adaptive Design for Clinical Trials with Survival Data

2005 ◽  
Vol 15 (4) ◽  
pp. 707-718 ◽  
Author(s):  
Gang Li ◽  
Weichung J. Shih ◽  
Yining Wang
Keyword(s):  
Clinical Trials ◽  
Survival Data ◽  
Adaptive Design ◽  
Two Stage

Analysing Survival Data from Clinical Trials and Observational Studies

Technometrics ◽  
1996 ◽  
Vol 38 (3) ◽  
pp. 299
Author(s):  
Eric R. Ziegel ◽  
E. Marubini ◽  
M. Valsecchi
Keyword(s):  
Clinical Trials ◽  
Survival Data ◽  
Observational Studies
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