The Role of Polyvinyl Alcohol in Cartilage Repair of the Ankle and First Metatarsophalangeal Joint

2018 ◽  
Vol 35 (1) ◽  
pp. 133-143 ◽  
Author(s):  
Thomas J. Chang
Keyword(s):  
Polyvinyl Alcohol ◽  
Cartilage Repair ◽  
Metatarsophalangeal Joint ◽  
First Metatarsophalangeal Joint

Role of MiR-146a in Cartilage Repair in Osteoarthritis of the First Metatarsophalangeal Joint by Influencing the TGF- β1/Smads Signaling Pathway

2020 ◽  
Vol 10 (4) ◽  
pp. 493-499
Author(s):  
Liming Wang ◽  
Juqing Guo ◽  
Chongbin Fang ◽  
Haibin Yan ◽  
Lukuan Du
Keyword(s):  
Signaling Pathway ◽  
Cartilage Repair ◽  
Cell Apoptosis ◽  
Transfection Efficiency ◽  
Metatarsophalangeal Joint ◽  
Inflammatory Factors ◽  
Serum Samples ◽  
First Metatarsophalangeal Joint ◽  
Proliferation Activity ◽  
Tgf Β1

Objective: To investigate miR-146a's role in cartilage repair in osteoarthritis of the first metatarsophalangeal joint (OFMJ). Methods: The serum samples of 30 OFMJ patients diagnosed in our hospital and 30 healthy people receiving physical examination were enrolled. The expression of miR-146a in those subjects was measured by qRT-PCR. Articular cartilage cells were isolated and transfected with lentivirus to silence or overexpress miR-146a. RT-PCR was performed to detect the transfection efficiency and the content of inflammatory factors. CCK-8 assay was to test cell proliferation activity and TUNEL assay was to detect cell apoptosis. The expressions of genes and proteins related to apoptosis and the TGF- β1/Smads signaling pathway were determined by RTPCR and Western blotting. Results: The serum miR-146a level in the patients with osteoarthritis of the first metatarsophalangeal joint was decreased significantly (p < 0.05). miR-146a showed a high expression in mimics group and was significantly lower in inhibitors group. The content of inflammatory factors in miR-146a mimics group was significantly reduced compared with other two groups (p < 0.05), and significantly higher level of inflammatory factors was detected in miR-146a inhibitors group (p < 0.05) along with increased number of cells and proliferation activity (p < 0.05) as well as increased cell apoptosis (p < 0.05). Bcl-2 was upregulated in miR-146a mimics group and Caspase-3 level was decreased. The expression of TGF-β 1/Smads was elevated in miR146a inhibitors group. Conclusion: MiR-146a can participate in the cartilage repair in osteoarthritis of the first metatarsophalangeal joint possibly through regulating TGF-β1/Smads signaling pathway.

Polyvinyl alcohol hemiarthroplasty for first metatarsophalangeal joint arthritis

2013 ◽  
Vol 24 (5) ◽  
pp. 493-497 ◽  
Author(s):  
Alastair S.E. Younger ◽  
Judith F. Baumhauer ◽  
Mark Glazebrook
Keyword(s):  
Polyvinyl Alcohol ◽  
Metatarsophalangeal Joint ◽  
First Metatarsophalangeal Joint ◽  
Joint Arthritis

First Metatarsophalangeal Joint Polyvinyl Alcohol Hydrogel Implant Hemiarthroplasty

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Alastair S.E. Younger ◽  
Mark A. Glazebrook ◽  
Timothy R. Daniels ◽  
Keith L. Wapner ◽  
Christopher W. DiGiovanni ◽  
...  
Keyword(s):  
Polyvinyl Alcohol ◽  
Metatarsophalangeal Joint ◽  
First Metatarsophalangeal Joint

Role of soft tissue structures as an etiology of hallux limitus

1993 ◽  
Vol 83 (4) ◽  
pp. 173-180 ◽  
Author(s):  
MN Durrant ◽  
KK Siepert
Keyword(s):  
Soft Tissue ◽  
Metatarsophalangeal Joint ◽  
Alternative Methods ◽  
First Metatarsophalangeal Joint ◽  
Anatomical Structures ◽  
Hallux Limitus ◽  
Tissue Structures

The authors establish common mechanical criteria for structures that can adversely affect dorsiflexion of the hallux, examine soft tissue anatomical structures around the first metatarsophalangeal joint that meet the established standards, and propose alternative methods of approaching the deformity surgically.

Correlation analysis of the x-ray and functional parameters from the results of chevron (Austin) osteotomy for hallux valgus

2020 ◽  
pp. 54-63
Author(s):  
Ruslan Khairutdinov ◽  
Timur Minasov ◽  
Ekaterina Yakupova ◽  
Elvina Mukhametzyanova
Keyword(s):  
Hallux Valgus ◽  
Rating Scale ◽  
Metatarsophalangeal Joint ◽  
Valgus Deformity ◽  
First Metatarsophalangeal Joint ◽  
Chevron Osteotomy ◽  
Hallux Valgus Deformity ◽  
Valgus Angle ◽  
The Right ◽  
Bone Structures

Hallux valgus is characterized by the appearance and growth of a painful “lump” in the region of the first metatarsophalangeal joint, the development of forefoot corns, and inability to choose the right shoes, which leads to a significant decrease in the quality of life of these patients. Corrective osteotomies that preserve the metatarsophalangeal joint, for example Austin (Chevron) osteotomy, are usually used for hallux valgus deformity of the I, II degrees. Radiography with the study of the hallux valgus angle (HVA), the intermetatarsal angle (IMA), the distal metatarsal articular angle (DMAA) is a research method that shows the true correlation between bone structures. The correlation between the radiological and functional indicators of osteotomy allows us to determine possible recommendations for indications for surgical treatment of Hallux valgus. Correlation shows that the largest correction of hallux valgus in older patients occurs due to a small adjustment of the angle of DMMA and HVA. IMA had the best correction after Austin osteotomy among patients of a younger age, then the HVA, and the DMMA had minimum correction according to the AOFAS rating scale (Kitaoka). The revealed correlations allow us to determine the correct tactics for the treatment of hallux valgus by identifying the benefits of Austin osteotomy.

The role of synovial fluid constituents in the lubrication of collagen-glycosaminoglycan scaffolds for cartilage repair

2021 ◽  
pp. 104445
Author(s):  
Austyn R. Matheson ◽  
Eamon J. Sheehy ◽  
Gregory D. Jay ◽  
W. Michael Scott ◽  
Fergal J. O'Brien ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Cartilage Repair
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