Interactions between oxidative stress and cardiorespiratory fitness: Old and new biomarkers

2020 ◽  
Vol 20-21 ◽  
pp. 15-22 ◽  
Author(s):  
Marco Bernardi ◽  
Ilaria Peluso
Keyword(s):  
Oxidative Stress ◽  
Cardiorespiratory Fitness ◽  
New Biomarkers

scholarly journals Increased Neurotoxicity Due to Activated Immune-Inflammatory and Nitro-Oxidative Stress Pathways in Patients with Suicide Attempts: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Asara Vasupanrajit ◽  
Ketsupar Jirakran ◽  
Chavit Tunvirachaisakul ◽  
Michael Maes
Keyword(s):  
Oxidative Stress ◽  
Immune Activation ◽  
Suicide Attempts ◽  
Psychiatric Patients ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Control Group ◽  
Healthy Controls ◽  
New Biomarkers

Background: Suicide attempts (SA) frequently occur in patients with mood disorders and schizophrenia, which are both accompanied by activated immune-inflammatory and nitro-oxidative (IO&NS) pathways. Methods: We searched PubMed, Google Scholar, and Web of Science, for articles published from inception until February 1, 2021. We included studies that compared blood biomarkers in psychiatric patients with (SA+) and without SA (SA-) and heathy controls and we combined different IO&NS biomarkers into immune, inflammatory, and neurotoxic profiles and used meta-analysis (random-effect model with restricted maximum-likelihood) to delineate effect sizes with 95% confidence interval (CI).Findings: Our search included 51 studies comprising 4.945 SA+ patients and 24.148 controls. We stratified the control group into healthy controls and SA- patients. SA+ patients showed significantly (p<0.001) increased immune activation (SMD: 1.044; CI: 0.599-1.489), inflammation (SMD: 1.109; CI: 0.505, 1.714), neurotoxicity (SMD: 0.879; CI: 0.465, 1.293), and lowered neuroprotection (SMD: 0.648; CI: 0.354, 0.941) as compared with healthy controls. When compared with SA- patients, those with SA+ showed significant (p<0.001) immune activation (SMD: 0.290; CI: 0.183, 0.397), inflammation (SMD: 0.311; CI: 0.191, 0.432), and neurotoxicity (SMD: 0.315; CI: 0.198, 0.432), and lowered neuroprotection (SMD: 0.341; CI: 0.167, 0.515). Patients with current, but not lifetime, SA showed significant (p<0.001) levels of inflammation and neurotoxicity as compared with controls. Conclusions: Patients with immune activation are at a higher risk of SA which may be explained by increased neurotoxicity due to inflammation and nitro-oxidative stress. This meta-analysis discovered new biomarkers of SA and therapeutic targets to treat individuals with SA.

scholarly journals Assessment Of The Relationship Between Oxidative Stress, Antioxidant Status, Inflammation And Cardiorespiratory Fitness In The Obese

2005 ◽  
Vol 37 (Supplement) ◽  
pp. S385
Author(s):  
Linda Zukley ◽  
Joshua Lowndes ◽  
Clinton L. Greenstone ◽  
Renee Melton ◽  
Von Nguyen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cardiorespiratory Fitness ◽  
Antioxidant Status ◽  
The Relationship

Assessment Of The Relationship Between Oxidative Stress, Antioxidant Status, Inflammation And Cardiorespiratory Fitness In The Obese

2005 ◽  
Vol 37 (Supplement) ◽  
pp. S385
Author(s):  
Linda Zukley ◽  
Joshua Lowndes ◽  
Clinton L. Greenstone ◽  
Renee Melton ◽  
Von Nguyen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cardiorespiratory Fitness ◽  
Antioxidant Status ◽  
The Relationship

Old and new biomarkers of oxidative stress in heart failure

2012 ◽  
Vol 9 (4) ◽  
pp. e189-e198 ◽  
Author(s):  
Sara Menazza ◽  
Marcella Canton ◽  
Elisa Sorato ◽  
Kerstin Boengler ◽  
Rainer Schulz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
New Biomarkers ◽  
Biomarkers Of Oxidative Stress

scholarly journals Formation of DNA etheno adducts in rodents and humans and their role in carcinogenesis.

1998 ◽  
Vol 45 (1) ◽  
pp. 145-161 ◽  
Author(s):  
A Barbin
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Vinyl Chloride ◽  
Dietary Factors ◽  
Lipid Peroxidation Product ◽  
Environmental Carcinogens ◽  
Increased Risk ◽  
Substitution Mutations ◽  
New Biomarkers

Ethenobases are exocyclic adducts formed with DNA by some environmental carcinogens such as vinyl chloride or urethane. In the last few years, they have received a renewed interest due to the development of sensitive techniques of analysis that made it possible to measure their formation in vivo. This minireview summarizes the information gained recently from the work of several laboratories, including ours. Increased levels of DNA etheno adducts have been measured in target tissues from rodents exposed to vinyl chloride or urethane. Hepatic tumours caused by exposure to vinyl chloride in humans and in rats and lung tumours induced by urethane in mice exhibit base pair substitution mutations in the ras and p53 genes which seem to be exposure-specific and consistent with the promutagenic properties of ethenobases. Background levels of etheno adducts have been detected in DNA from non-exposed humans or animals, pointing to an alternative, endogenous pathway of formation. This background may be affected by dietary factors. It could arise from the reaction of trans-4-hydroxy-2-nonenal (or its epoxide 2,3-epoxy-4-hydroxynonanal), a lipid peroxidation product, with nucleic acid bases. Elevated levels of etheno adducts are found in hepatic DNA from humans and rodents with genetic predisposition to oxidative stress and lipid peroxidation in the liver, and with an associated increased risk of liver cancer. These data suggest that DNA ethenobases could serve as new biomarkers of oxidative stress/lipid peroxidation.

scholarly journals Effect of Cardiorespiratory Fitness on Vascular Regulation and Oxidative Stress in Postmenopausal Women

Hypertension ◽  
2009 ◽  
Vol 54 (5) ◽  
pp. 1014-1020 ◽  
Author(s):  
Vincent Pialoux ◽  
Allison D. Brown ◽  
Richard Leigh ◽  
Christine M. Friedenreich ◽  
Marc J. Poulin
Keyword(s):  
Oxidative Stress ◽  
Postmenopausal Women ◽  
Cardiorespiratory Fitness ◽  
Vascular Regulation ◽  
And Oxidative Stress

scholarly journals Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial

2018 ◽  
Vol 7 (12) ◽  
pp. 477 ◽  
Author(s):  
Alberto Soriano-Maldonado ◽  
Pablo Morillas-de-Laguno ◽  
José Sabio ◽  
Blanca Gavilán-Carrera ◽  
Antonio Rosales-Castillo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systemic Lupus Erythematosus ◽  
Arterial Stiffness ◽  
Aerobic Exercise ◽  
Cardiorespiratory Fitness ◽  
Lupus Erythematosus ◽  
Controlled Trial ◽  
Control Group ◽  
Systemic Lupus ◽  
Necrosis Factor Alpha

This study assessed the effect of 12-week aerobic exercise on arterial stiffness (primary outcome), inflammation, oxidative stress, and cardiorespiratory fitness (secondary outcomes) in women with systemic lupus erythematosus (SLE). In a non-randomized clinical trial, 58 women with SLE were assigned to either aerobic exercise (n = 26) or usual care (n = 32). The intervention comprised 12 weeks of aerobic exercise (2 sessions × 75 min/week) between 40–75% of the individual’s heart rate reserve. At baseline and at week 12, arterial stiffness was assessed through pulse wave velocity (PWV), inflammatory (i.e., high-sensitivity C-reactive protein [hsCRP], tumor necrosis factor alpha [TFN-α], and inteleukin 6 [IL-6]) and oxidative stress (i.e., myeloperoxidase [MPO]) markers were obtained from blood samples, and cardiorespiratory fitness was assessed (Bruce test). There were no between-group differences in the changes in arterial stiffness (median PWV difference −0.034, 95% CI −0.42 to 0.36 m/s; p = 0.860) or hsCRP, TNF-α, IL-6, and MPO (all p > 0.05) at week 12. In comparison to the control group, the exercise group significantly increased cardiorespiratory fitness (median difference 2.26 minutes, 95% CI 0.98 to 3.55; p = 0.001). These results suggest that 12 weeks of progressive treadmill aerobic exercise increases cardiorespiratory fitness without exacerbating arterial stiffness, inflammation, or oxidative stress in women with SLE.

scholarly journals Increased neurotoxicity due to activated immune-inflammatory and nitro-oxidative stress pathways in patients with suicide attempts: a systematic review and meta-analysis.

2021 ◽  
Author(s):  
Asara Vasupanrajit ◽  
Ketsupar Jirakran ◽  
Chavit Tunvirachaisakul ◽  
Michael Maes
Keyword(s):  
Oxidative Stress ◽  
Immune Activation ◽  
Suicide Attempts ◽  
Psychiatric Patients ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Control Group ◽  
Healthy Controls ◽  
New Biomarkers

Background: Suicide attempts (SA) frequently occur in patients with mood disorders and schizophrenia, which are both accompanied by activated immune-inflammatory and nitro-oxidative (IO&NS) pathways. Methods: We searched PubMed, Google Scholar, and Web of Science, for articles published from inception until February 1, 2021. We included studies that compared blood biomarkers in psychiatric patients with (SA+) and without SA (SA-) and heathy controls and we combined different IO&NS biomarkers into immune, inflammatory, and neurotoxic profiles and used meta-analysis (random-effect model with restricted maximum-likelihood) to delineate effect sizes with 95% confidence interval (CI). Findings: Our search included 51 studies comprising 4.945 SA+ patients and 24.148 controls. We stratified the control group into healthy controls and SA- patients. SA+ patients showed significantly (p<0.001) increased immune activation (SMD: 1.044; CI: 0.599-1.489), inflammation (SMD: 1.109; CI: 0.505, 1.714), neurotoxicity (SMD: 0.879; CI: 0.465, 1.293), and lowered neuroprotection (SMD: 0.648; CI: 0.354, 0.941) as compared with healthy controls. When compared with SA- patients, those with SA+ showed significant (p<0.001) immune activation (SMD: 0.290; CI: 0.183, 0.397), inflammation (SMD: 0.311; CI: 0.191, 0.432), and neurotoxicity (SMD: 0.315; CI: 0.198, 0.432), and lowered neuroprotection (SMD: 0.341; CI: 0.167, 0.515). Patients with current, but not lifetime, SA showed significant (p<0.001) levels of inflammation and neurotoxicity as compared with controls. Conclusions: Patients with immune activation are at a higher risk of SA which may be explained by increased neurotoxicity due to inflammation and nitro-oxidative stress. This meta-analysis discovered new biomarkers of SA and therapeutic targets to treat individuals with SA.

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