Role of epigenetics in tumor induction by non-genotoxic carcinogens

2017 ◽  
Vol 6 ◽  
pp. 42-49
Author(s):  
Volodymyr P. Tryndyak
Keyword(s):  
Tumor Induction ◽  
Genotoxic Carcinogens

The Role of Mutations in Liver Tumor Induction in Mice

1972 ◽  
Vol 50 (3) ◽  
pp. 539 ◽  
Author(s):  
Howard J. Curtis ◽  
John Tilley
Keyword(s):  
Liver Tumor ◽  
Tumor Induction

scholarly journals On the issue of nongenotoxic cancerogenes

2021 ◽  
Vol 29 (4) ◽  
pp. 51-55
Author(s):  
Yulia A. Revazova ◽  
Nataliya A. Ilyushina
Keyword(s):  
Genetic Control ◽  
Mechanisms Of Action ◽  
The Body ◽  
Malignant Neoplasms ◽  
Core Content ◽  
Genotoxic Carcinogens ◽  
Carcinogenic Effects ◽  
Genetic Structures

Introduction. Chemical, physical or biological factors that can cause the formation and expansion of cancer cells are diverse in terms of both activity and mechanisms of action, which leads to the complexity of assessing the risk of developing malignant neoplasms. The aim. Discussion of the classification of carcinogens based on their ability to interact with DNA cell and possible mechanisms of genetic control of carcinogenesis processes induced by non-genotoxic carcinogens. Core content. The article draws attention to some controversial points related to the attribution of factors acting on the body to genotoxic or non-genotoxic carcinogens. The terminology used in the literature to describe genotoxic (mutagenic) and carcinogenic factors is presented. The mechanisms of action of non-genotoxic carcinogens are discussed. The important role of experts determining the danger to public health of factors with potential genotoxicity and carcinogenicity is noted. Conclusion. Non-genotoxic carcinogens are capable of inducing malignant growth through mechanisms not associated with direct damage to genetic structures in the cell. However, the realization of carcinogenic effects caused by such factors is determined by various mechanisms of genetic control.

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