Conjoint fluctuations of PFC-mediated processes and behavior: An investigation of error-related neural mechanisms in relation to sustained attention

Cortex ◽  
2021 ◽  
Author(s):  
Matthieu Chidharom ◽  
Julien Krieg ◽  
Bich-Thuy Pham ◽  
Anne Bonnefond
Neuron ◽  
2018 ◽  
Vol 99 (4) ◽  
pp. 854-865.e5 ◽  
Author(s):  
Randolph F. Helfrich ◽  
Ian C. Fiebelkorn ◽  
Sara M. Szczepanski ◽  
Jack J. Lin ◽  
Josef Parvizi ◽  
...  

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Mehdi Behroozi ◽  
Xavier Helluy ◽  
Felix Ströckens ◽  
Meng Gao ◽  
Roland Pusch ◽  
...  

Abstract Animal-fMRI is a powerful method to understand neural mechanisms of cognition, but it remains a major challenge to scan actively participating small animals under low-stress conditions. Here, we present an event-related functional MRI platform in awake pigeons using single-shot RARE fMRI to investigate the neural fundaments for visually-guided decision making. We established a head-fixated Go/NoGo paradigm, which the animals quickly learned under low-stress conditions. The animals were motivated by water reward and behavior was assessed by logging mandibulations during the fMRI experiment with close to zero motion artifacts over hundreds of repeats. To achieve optimal results, we characterized the species-specific hemodynamic response function. As a proof-of-principle, we run a color discrimination task and discovered differential neural networks for Go-, NoGo-, and response execution-phases. Our findings open the door to visualize the neural fundaments of perceptual and cognitive functions in birds—a vertebrate class of which some clades are cognitively on par with primates.


2020 ◽  
Vol 43 (1) ◽  
pp. 391-415 ◽  
Author(s):  
David A. McCormick ◽  
Dennis B. Nestvogel ◽  
Biyu J. He

Neural activity and behavior are both notoriously variable, with responses differing widely between repeated presentation of identical stimuli or trials. Recent results in humans and animals reveal that these variations are not random in their nature, but may in fact be due in large part to rapid shifts in neural, cognitive, and behavioral states. Here we review recent advances in the understanding of rapid variations in the waking state, how variations are generated, and how they modulate neural and behavioral responses in both mice and humans. We propose that the brain has an identifiable set of states through which it wanders continuously in a nonrandom fashion, owing to the activity of both ascending modulatory and fast-acting corticocortical and subcortical-cortical neural pathways. These state variations provide the backdrop upon which the brain operates, and understanding them is critical to making progress in revealing the neural mechanisms underlying cognition and behavior.


1978 ◽  
pp. 196-217
Author(s):  
Donald A. Dewsbury

Marijuana ◽  
1974 ◽  
pp. 157-188
Author(s):  
LOREN L. MILLER ◽  
WILLIAM G. DREW

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