Cognitive correlates and baseline predictors of future development of visual hallucinations in dementia with Lewy bodies

Cortex ◽  
2021 ◽  
Author(s):  
Stefania Pezzoli ◽  
Annachiara Cagnin ◽  
Cinzia Bussè ◽  
Giovanni Zorzi ◽  
Federica Fragiacomo ◽  
...  
Keyword(s):  
Future Development ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Visual Hallucinations ◽  
Cognitive Correlates

Clinical and cognitive correlates of visual hallucinations in dementia with Lewy bodies

2012 ◽  
Vol 84 (5) ◽  
pp. 505-510 ◽  
Author(s):  
A. Cagnin ◽  
F. Gnoato ◽  
N. Jelcic ◽  
S. Favaretto ◽  
G. Zarantonello ◽  
...  
Keyword(s):  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Visual Hallucinations ◽  
Cognitive Correlates

scholarly journals Evaluating a novel behavioral paradigm for visual hallucinations in Dementia with Lewy bodies

Aging Brain ◽  
2021 ◽  
Vol 1 ◽  
pp. 100011
Author(s):  
Joseph R. Phillips ◽  
Elie Matar ◽  
Kaylena A. Ehgoetz Martens ◽  
Ahmed A. Moustafa ◽  
Glenda M. Halliday ◽  
...  
Keyword(s):  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Visual Hallucinations ◽  
Behavioral Paradigm

A Detailed Phenomenological Comparison of Complex Visual Hallucinations in Dementia With Lewy Bodies and Alzheimer's Disease

1997 ◽  
Vol 9 (4) ◽  
pp. 381-388 ◽  
Author(s):  
Clive Ballard ◽  
Ian McKeith ◽  
Richard Harrison ◽  
John O'Brien ◽  
Peter Thompson ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Time Of Day ◽  
Visual Hallucinations ◽  
Dementia Patients ◽  
Core Feature ◽  
Definition Of

Visual hallucinations (VH) are a core feature of dementia with Lewy bodies (DLB), but little is known about their phenomenology. A total of 73 dementia patients (42 DLB, 30 Alzheimer's disease [AD], 1 undiagnosed) in contact with clinical services were assessed with a detailed standardized inventory. DLB was diagnosed according to the criteria of McKeith and colleagues, AD was diagnosed using the NINCDS-ADRDA criteria. Autopsy confirmation has been obtained when possible. VH were defined using the definition of Burns and colleagues. Detailed descriptions of hallucinatory experiences were recorded. Annual follow-up interviews were undertaken. The clinical diagnosis has been confirmed in 18 of the 19 cases that have come to autopsy. A total of 93% of DLB patients and 27% of AD patients experienced VH. DLB patients were significantly more likely to experience multiple VH that persisted over follow-up. They were significantly more likely to hear their VH speak but there were no significant differences in the other phenomenological characteristics including whether the hallucinations moved, the time of day that they were experienced, their size, the degree of insight, and whether they were complete. VH may be more likely to be multiple, to speak, and to be persistent in DLB patients. These characteristics could potentially aid accurate diagnosis.

Changes of metabolic connectivity in dementia with Lewy bodies with visual hallucinations: a 18F-FDG PET/MR study

2021 ◽  
Author(s):  
Giovanni Zorzi ◽  
Diego Cecchin ◽  
Cinzia Busse ◽  
Giulia Perini ◽  
Maurizio Corbetta ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Visual Hallucinations ◽  
Metabolic Connectivity ◽  
18F Fdg ◽  
Mr Study

scholarly journals 1230 An unusual presentation of dementia with Lewy bodies in a septuagenarian

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A469-A470
Author(s):  
Eric S Geil ◽  
Christian Agudelo ◽  
Kori Ascher ◽  
Xiaoyan Sun ◽  
Naymee Velez-Ruiz ◽  
...  
Keyword(s):  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Apnea Hypopnea Index ◽  
Visual Hallucinations ◽  
Lower Extremity Weakness ◽  
Pressure Therapy ◽  
Uncommon Presentation ◽  
Continuous Eeg ◽  
Rem Sleep Without Atonia ◽  
Continuous Eeg Monitoring

Abstract Introduction Dementia with Lewy bodies (DLB) can be associated with degeneration of the hypocretin system and reduced hypocretin levels. However, reports of DLB initially presenting with narcolepsy with cataplexy symptoms are sparse. Report of Case A 77-year-old man presents with two years of new onset hypersomnia, tremors, memory difficulties, and gait instability. Before his sleep evaluation, he was started on levetiracetam for suspected seizures and levodopa for suspected Parkinson’s disease, without improvement. During his evaluation for hypersomnia, he reported loud snoring, witnessed apneas, sleep maintenance difficulty, hypnagogic hallucinations of well-formed images, and vivid dreams with dream enactment behavior occurring almost nightly. He had witnessed episodes of cataplexy described as transient lower extremity weakness with associated bifacial weakness, inability to speak, and no loss of consciousness, self-injury, loss of bowel/bladder control, or post-event symptoms. These events completely resolved after 1-minute, occurred while sitting or standing, and were spontaneous or triggered by anger or anxiety. His Epworth Sleepiness Scale was 18 and Ullanlinna Narcolepsy Scale was 35, suggestive of narcolepsy with cataplexy. Physical examination did not reveal Parkinsonism or resting tremor. He subsequently underwent a baseline polysomnogram that showed an apnea-hypopnea index of 32.7 events/hour. During an in-laboratory titration study, he had REM sleep without atonia. A 30-minute EEG was interpreted as normal and a typical cataplexy-like event captured during continuous EEG monitoring had no ictal correlate. Despite adherence to positive airway pressure therapy, he continued to have hypersomnia, cataplexy, and visual hallucinations during transitions from wake to sleep. He was tapered off levetiracetam and levodopa with a plan for further evaluation of probable DLB. Conclusion Narcolepsy with cataplexy symptoms is an uncommon presentation of probable DLB as seen in this case with two core clinical features of DLB (RBD and visual hallucinations), suggesting neurodegeneration of the hypocretin system.

Clinical and cognitive correlates of selective regional retinal thinning in dementia with lewy bodies

2019 ◽  
Vol 34 (10) ◽  
pp. 1582-1583
Author(s):  
Federica Fragiacomo ◽  
Silvia Miante ◽  
Marta Pengo ◽  
Cinzia Bussè ◽  
Giovanni Zorzi ◽  
...  
Keyword(s):  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Cognitive Correlates ◽  
Retinal Thinning
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