The correlation between apraxia and neglect in the right hemisphere: A voxel-based lesion-symptom mapping study in 138 acute stroke patients

Cortex ◽  
2020 ◽  
Vol 132 ◽  
pp. 166-179
Author(s):  
Andrea Dressing ◽  
Markus Martin ◽  
Lena-Alexandra Beume ◽  
Dorothee Kuemmerer ◽  
Horst Urbach ◽  
...  
Keyword(s):  
Acute Stroke ◽  
Right Hemisphere ◽  
Mapping Study ◽  
Stroke Patients ◽  
Lesion Symptom Mapping ◽  
The Right

scholarly journals Are visual working memory and episodic memory distinct processes? Insight from stroke patients by lesion-symptom mapping

2021 ◽  
Author(s):  
Selma Lugtmeijer ◽  
◽  
Linda Geerligs ◽  
Frank Erik de Leeuw ◽  
Edward H. F. de Haan ◽  
...  
Keyword(s):  
Working Memory ◽  
Episodic Memory ◽  
Visual Working Memory ◽  
Visual Memory ◽  
Right Hemisphere ◽  
Memory Task ◽  
Stroke Patients ◽  
Lesion Symptom Mapping ◽  
Criterion Setting ◽  
The Right

AbstractWorking memory and episodic memory are two different processes, although the nature of their interrelationship is debated. As these processes are predominantly studied in isolation, it is unclear whether they crucially rely on different neural substrates. To obtain more insight in this, 81 adults with sub-acute ischemic stroke and 29 elderly controls were assessed on a visual working memory task, followed by a surprise subsequent memory test for the same stimuli. Multivariate, atlas- and track-based lesion-symptom mapping (LSM) analyses were performed to identify anatomical correlates of visual memory. Behavioral results gave moderate evidence for independence between discriminability in working memory and subsequent memory, and strong evidence for a correlation in response bias on the two tasks in stroke patients. LSM analyses suggested there might be independent regions associated with working memory and episodic memory. Lesions in the right arcuate fasciculus were more strongly associated with discriminability in working memory than in subsequent memory, while lesions in the frontal operculum in the right hemisphere were more strongly associated with criterion setting in subsequent memory. These findings support the view that some processes involved in working memory and episodic memory rely on separate mechanisms, while acknowledging that there might also be shared processes.

scholarly journals Testing Conclusions From Functional Imaging of Working Memory with Data From Acute Stroke

2007 ◽  
Vol 18 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Lisa E. Philipose ◽  
Hannah Alphs ◽  
Vivek Prabhakaran ◽  
Argye E. Hillis
Keyword(s):  
Working Memory ◽  
Acute Stroke ◽  
Functional Imaging ◽  
Right Hemisphere ◽  
Spatial Working Memory ◽  
Verbal Working Memory ◽  
Stroke Patients ◽  
Imaging Results ◽  
Cortical Stroke ◽  
The Right

Functional imaging studies indicate that the left hemisphere mediates verbal working memory, while the right hemisphere mediates both verbal and spatial working memory. We evaluated acute stroke patients with working memory tests and imaging to identify whether unilateral dysfunction causes deficits in spatial and/or verbal working memory deficits. While left cortical stroke patients had verbal working memory impairments (p< 0.003), right cortical stroke patients had both verbal (p< 0.007) and spatial working memory (p< 0.03) impairments, confirming functional imaging results. Patients with transient ischemic stroke and patients with non-cortical stroke did not have significant deficits in working memory in either modality.

Right- and Left-Lateralised Neglect are not Anatomically Homologous: A Voxel-Lesion Symptom Mapping Study

2021 ◽  
Author(s):  
Margaret Moore ◽  
Celine Gillebert ◽  
Nele Demeyere
Keyword(s):  
Acute Stroke ◽  
Left Hemisphere ◽  
Right Hemisphere ◽  
Internal Capsule ◽  
Neural Correlates ◽  
Visuospatial Neglect ◽  
Routine Clinical Imaging ◽  
Posterior Parietal ◽  
Lesion Symptom Mapping ◽  
The Right

Visuospatial neglect is a heterogenous syndrome which can occur following damage to either right or left hemisphere areas. This study employs voxel-lesion symptom mapping to identify the neural correlates of left and right egocentric and allocentric neglect in a large acute stroke cohort.A cohort of 446 acute stroke survivors (age = 26-95, 44% female) completed neuropsychological neglect assessment and routine clinical imaging. Similar to previous investigations, left egocentric and left allocentric neglect were associated with damage to distinct clusters of voxels within the posterior parietal and temporo-parietal junction areas. Unlike previous investigations, right egocentric neglect was found to most strongly associated with damage to more posterior voxels within left occipital cortical areas. Right allocentric neglect was found to be most strongly associated with damage to the anterior limb of the left internal capsule. Interestingly, the right hemisphere homologues of the areas implicated in right-lateralised neglect were not overlapping with those associated with left neglect impairment. This dissociation was present across both egocentric and allocentric neglect impairment. The results of this investigation suggest that right egocentric/allocentric neglect should not be characterised as a consequence of damage to left-hemisphere homologues of the right hemisphere attentional systems. These findings support the characterisation of visuospatial neglect as a heterogenous cluster of impairments rather than a unitary syndrome and provide novel insight into the neural correlates of spatial attention.

Visual neglect after left-hemispheric lesions: a voxel-based lesion–symptom mapping study in 121 acute stroke patients

2016 ◽  
Vol 235 (1) ◽  
pp. 83-95 ◽  
Author(s):  
Lena-Alexandra Beume ◽  
Markus Martin ◽  
Christoph P. Kaller ◽  
Stefan Klöppel ◽  
Charlotte S. M. Schmidt ◽  
...  
Keyword(s):  
Acute Stroke ◽  
Mapping Study ◽  
Visual Neglect ◽  
Stroke Patients ◽  
Lesion Symptom Mapping

scholarly journals Are visual working memory and episodic memory distinct processes? Insight from stroke patients by lesion-symptom mapping.

2021 ◽  
Author(s):  
Selma Lugtmeijer ◽  
Linda Geerligs ◽  
Frank Erik De Leeuw ◽  
Edward H. F. De Haan ◽  
Roy P. C. Kessels
Keyword(s):  
Working Memory ◽  
Episodic Memory ◽  
Visual Working Memory ◽  
Visual Memory ◽  
Right Hemisphere ◽  
Memory Task ◽  
Stroke Patients ◽  
Lesion Symptom Mapping ◽  
Criterion Setting ◽  
The Right

Abstract Working memory and episodic memory are two different processes, although the nature of their interrelationship is debated. As these processes are predominantly studied in isolation, it is unclear whether they crucially rely on different neural substrates. To obtain more insight in this, eighty-one adults with sub-acute ischemic stroke and twenty-nine elderly controls were assessed on a visual working memory task, followed by a surprise subsequent memory test for the same stimuli. Multivariate, atlas- and track-based lesion-symptom mapping (LSM) analyses were performed to identify anatomical correlates of visual memory. Behavioral results gave moderate evidence for independence between discriminability in working memory and subsequent memory, and strong evidence for a correlation in response bias on the two tasks in stroke patients. LSM analyses suggested there might be independent regions associated with working memory and episodic memory. Lesions in the right arcuate fasciculus were more strongly associated with discriminability in working memory than in subsequent memory, while lesions in the frontal operculum in the right hemisphere were more strongly associated with criterion setting in subsequent memory. These findings support the view that some processes involved in working memory and episodic memory rely on separate mechanisms, while acknowledging that there might also be shared processes.

scholarly journals Is Lateropulsion Really Related with a Specific Lesion of the Brain?

2021 ◽  
Vol 11 (3) ◽  
pp. 354
Author(s):  
Kyoung Lee ◽  
Sang Yoo ◽  
Eun Ji ◽  
Woo Hwang ◽  
Yeun Yoo ◽  
...  
Keyword(s):  
Right Hemisphere ◽  
Parietal Lobe ◽  
Inferior Frontal Gyrus ◽  
Brain Lesions ◽  
Vertical Posture ◽  
Lesion Volume ◽  
Precentral Gyrus ◽  
Stroke Patients ◽  
The Right ◽  
Right Hemisphere Stroke

Lateropulsion (pusher syndrome) is an important barrier to standing and gait after stroke. Although several studies have attempted to elucidate the relationship between brain lesions and lateropulsion, the effects of specific brain lesions on the development of lateropulsion remain unclear. Thus, the present study investigated the effects of stroke lesion location and size on lateropulsion in right hemisphere stroke patients. The present retrospective cross-sectional observational study assessed 50 right hemisphere stroke patients. Lateropulsion was diagnosed and evaluated using the Scale for Contraversive Pushing (SCP). Voxel-based lesion symptom mapping (VLSM) analysis with 3T-MRI was used to identify the culprit lesion for SCP. We also performed VLSM controlling for lesion volume as a nuisance covariate, in a multivariate model that also controlled for other factors contributing to pusher behavior. VLSM, combined with statistical non-parametric mapping (SnPM), identified the specific region with SCP. Lesion size was associated with lateropulsion. The precentral gyrus, postcentral gyrus, inferior frontal gyrus, insula and subgyral parietal lobe of the right hemisphere seemed to be associated with the lateropulsion; however, after adjusting for lesion volume as a nuisance covariate, no lesion areas were associated with the SCP scores. The size of the right hemisphere lesion was the only factor most strongly associated with lateropulsion in patients with stroke. These results may be useful for planning rehabilitation strategies of restoring vertical posture and understanding the pathophysiology of lateropulsion in stroke patients.

scholarly journals Sensory deficits in ipsilesional upper-extremity in chronic stroke patients

2015 ◽  
Vol 73 (10) ◽  
pp. 834-839 ◽  
Author(s):  
Núbia Maria Freire Vieira Lima ◽  
Karina Cândido Menegatti ◽  
Érica Yu ◽  
Natália Yumi Sacomoto ◽  
Thais Botossi Scalha ◽  
...  
Keyword(s):  
Right Hemisphere ◽  
Thermal Sensation ◽  
Chronic Stroke ◽  
Sensory Loss ◽  
Stroke Patients ◽  
Sensory Assessment ◽  
Sensory Deficits ◽  
Left Handed ◽  
Right Hemisphere Damage ◽  
The Right

Objective To investigate somatosensory deficits in the ipsilesional wrist and hand in chronic stroke patients and correlate these deficits with contralesional sensorimotor dysfunctions, functional testing, laterality and handedness.Methods Fifty subjects (twenty-two healthy volunteers and twenty-eight stroke patients) underwent evaluation with Semmes-Weinstein monofilaments, the sensory and motor Fugl-Meyer Assessment, the Nottingham Sensory Assessment in both wrists and hands and functional tests.Results Twenty-five patients had sensory changes in the wrist and hand contralateral to the stroke, and eighteen patients (64%) had sensory deficits in the ipsilesional wrist and hand. The most significant ipsilesional sensory loss was observed in the left-handed patients. We found that the patients with brain damage in the right hemisphere had better scores for ipsilesional tactile sensation.Conclusions A reduction in ipsilesional conscious proprioception, tactile or thermal sensation was found in stroke subjects. Right hemisphere damage and right-handed subjects had better scores in ipsilesional tactile sensation.

scholarly journals Componential Network for the Recognition of Tool-Associated Actions: Evidence from Voxel-based Lesion-Symptom Mapping in Acute Stroke Patients

2016 ◽  
Author(s):  
Markus Martin ◽  
Andrea Dressing ◽  
Tobias Bormann ◽  
Charlotte S. M. Schmidt ◽  
Dorothee Kümmerer ◽  
...  
Keyword(s):  
Acute Stroke ◽  
Stroke Patients ◽  
Lesion Symptom Mapping

Corrigendum to “The right hemisphere is dominant in organization of visual search—A study in stroke patients” [Behav. Brain Res. 304 (2016) 71–79]

2017 ◽  
Vol 319 ◽  
pp. 234
Author(s):  
Antonia F. Ten Brink ◽  
J. Matthijs Biesbroek ◽  
Hugo J. Kuijf ◽  
Stefan Van der Stigchel ◽  
Quirien Oort ◽  
...  
Keyword(s):  
Visual Search ◽  
Right Hemisphere ◽  
Stroke Patients ◽  
The Right
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