‘Real-life’ hippocampal-dependent spatial memory impairments in Huntington's disease

Cortex ◽  
2019 ◽  
Vol 119 ◽  
pp. 46-60 ◽  
Author(s):  
Yifat Glikmann-Johnston ◽  
Anna M. Carmichael ◽  
Emily-Clare Mercieca ◽  
Julie C. Stout
Keyword(s):  
Spatial Memory ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Real Life ◽  
Memory Impairments

scholarly journals Huntington's disease patients display progressive deficits in hippocampal-dependent cognition during a task of spatial memory

Cortex ◽  
2019 ◽  
Vol 119 ◽  
pp. 417-427 ◽  
Author(s):  
Kate L. Harris ◽  
Matthew Armstrong ◽  
Rachel Swain ◽  
Sharon Erzinclioglu ◽  
Tilak Das ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Huntington's Disease ◽  
Huntington’S Disease

scholarly journals Spatial memory in Huntington’s disease: A comparative review of human and animal data

2019 ◽  
Vol 98 ◽  
pp. 194-207 ◽  
Author(s):  
Yifat Glikmann-Johnston ◽  
Kyle D. Fink ◽  
Peter Deng ◽  
Audrey Torrest ◽  
Julie C. Stout
Keyword(s):  
Spatial Memory ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Animal Data ◽  
Comparative Review

Monitoring the Motor Phenotype in Huntington’s Disease by Analysis of Keyboard Typing During Real Life Computer Use

2021 ◽  
pp. 1-10
Author(s):  
Christina Lang ◽  
Christopher Gries ◽  
Katrin S. Lindenberg ◽  
Jan Lewerenz ◽  
Stefanie Uhl ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Clinical Manifestation ◽  
Real Life ◽  
Fine Motor ◽  
Healthy Controls ◽  
Prodromal Phase ◽  
Cross Sectional ◽  
Keyboard Typing ◽  
Motor Phenotype

Background: Besides cognitive and psychiatric abnormalities, motor symptoms are the most prominent in Huntington’s disease. The manifest disease is preceded by a prodromal phase with subtle changes such as fine motor disturbances or concentration problems. Objective: Movement disorders show a high variation in their clinical manifestation depending on condition and external influences. Therefore, devices for continuous measurements, which patients use in their daily life and which can monitor motor abnormalities, in addition to the medical examination, might be useful. The aim of current scientific efforts is to find markers that reflect the prodromal phase in gene carriers. This is important for future interventional studies, as future therapies should be applied at the stage of neuronal dysfunction, i.e., before the clinical manifestation. Methods: We performed a software-supported, continuous monitoring of keyboard typing on the participants’ own computer to evaluate this method as a tool to assess the motor phenotype in HD. We included 40 participants and obtained sufficient data from 25 participants, 12 of whom were manifest HD patients, 7 HD gene expansion carriers (HDGEC) and 6 healthy controls. Results: In a cross-sectional analysis we found statistically significant higher typing inconsistency in HD patients compared to controls. Typing inconsistency compared between HDGEC and healthy controls showed a trend to higher inconsistency levels in HDGEC. We found correlations between typing cadence and clinical scores: the UHDRS finger tapping item, the composite UHDRS and the CAP score. Conclusion: The typing cadence inconsistency is an appropriate marker to evaluate fine motor skills of HD patients and HDGEC and is correlated to established clinical measurements.

scholarly journals Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease

2011 ◽  
Vol 20 (21) ◽  
pp. 4232-4247 ◽  
Author(s):  
Albert Giralt ◽  
Ana Saavedra ◽  
Olga Carretón ◽  
Xavier Xifró ◽  
Jordi Alberch ◽  
...  
Keyword(s):  
Recognition Memory ◽  
Spatial Memory ◽  
Huntington's Disease ◽  
Huntington’S Disease

Pervasive autobiographical memory impairments in Huntington’s disease

2019 ◽  
Vol 127 ◽  
pp. 123-130 ◽  
Author(s):  
Anna M. Carmichael ◽  
Muireann Irish ◽  
Yifat Glikmann-Johnston ◽  
Paldeep Singh ◽  
Julie C. Stout
Keyword(s):  
Huntington's Disease ◽  
Autobiographical Memory ◽  
Huntington’S Disease ◽  
Memory Impairments

F7 Spatial memory in huntington’s disease: a comparative review of human and animal data

2016 ◽  
Vol 87 (Suppl 1) ◽  
pp. A50.3-A51
Author(s):  
Yifat Glikmann-Johnston ◽  
Kyle D Fink ◽  
Audrey Torrest ◽  
Jan A Nolta ◽  
Julie C Stout
Keyword(s):  
Spatial Memory ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Animal Data ◽  
Comparative Review

Hippocampal and striatal volumes correlate with spatial memory impairment in Huntington’s disease

2021 ◽  
Author(s):  
Yifat Glikmann‐Johnston ◽  
Emily‐Clare Mercieca ◽  
Anna M. Carmichael ◽  
Bonnie Alexander ◽  
Ian H. Harding ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Memory Impairment

scholarly journals The Role of Virtual Reality in Screening, Diagnosing, and Rehabilitating Spatial Memory Deficits

2021 ◽  
Vol 15 ◽  
Author(s):  
Miles Jonson ◽  
Sinziana Avramescu ◽  
Derek Chen ◽  
Fahad Alam
Keyword(s):  
Virtual Reality ◽  
Spatial Memory ◽  
Functional Disability ◽  
Real Life ◽  
Memory Deficits ◽  
Diagnostic Tools ◽  
Memory Impairments ◽  
The Road ◽  
Simulated Environment ◽  
On The Road

Impairment of spatial memory, including an inability to recall previous locations and navigate the world, is often one of the first signs of functional disability on the road to cognitive impairment. While there are many screening and diagnostic tools which attempt to measure spatial memory ability, they are often not representative of real-life situations and can therefore lack applicability. One potential solution to this problem involves the use of virtual reality (VR), which immerses individuals in a virtually-simulated environment, allowing for scenarios more representative of real-life without any of the associated risks. Here, we review the evidence surrounding the use of VR for the screening and diagnosis of spatial memory impairments, including potential limitations and how it compares to standard neuropsychological tests. We will also discuss the evidence regarding the potential use of VR in the rehabilitation of spatial memory deficits, which has not been well studied, but which could be game-changing if proven successful.

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