Lexical retrieval treatment in primary progressive aphasia: An investigation of treatment duration in a heterogeneous case series

Cortex ◽  
2019 ◽  
Vol 115 ◽  
pp. 133-158 ◽  
Author(s):  
Karen Croot ◽  
Theresa Raiser ◽  
Cathleen Taylor-Rubin ◽  
Leanne Ruggero ◽  
Nibal Ackl ◽  
...  
Keyword(s):  
Treatment Duration ◽  
Case Series ◽  
Primary Progressive Aphasia ◽  
Lexical Retrieval ◽  
Progressive Aphasia ◽  
Primary Progressive

Early and Mild Phases of Primary Progressive Aphasia: A Case Series

2017 ◽  
Vol 10 (2) ◽  
pp. 136-142
Author(s):  
Jessica Powell ◽  
James Lendrum ◽  
Rosalind Huff ◽  
Christine Belden ◽  
Marwan N. Sabbagh
Keyword(s):  
Case Series ◽  
Primary Progressive Aphasia ◽  
Progressive Aphasia ◽  
Primary Progressive

Making the Right Connections: Maximizing Lexical Generalization in Lexical Impairments in Primary Progressive Aphasia and Alzheimer's Disease

2021 ◽  
pp. 1-16
Author(s):  
Ashleigh Beales ◽  
Anne Whitworth ◽  
Jade Cartwright ◽  
Peter K. Panegyres ◽  
Robert T. Kane
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Family Members ◽  
Primary Progressive Aphasia ◽  
Lexical Retrieval ◽  
Connected Speech ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Word Classes ◽  
The Impact

Purpose Positive intervention effects following lexical retrieval interventions are increasingly reported with people with progressive language impairments; however, generalization of therapy gains are less frequently evident and less well understood. This study sought to explore the impact of specific therapy ingredients on generalization outcomes. Method Twelve participants with progressive lexical retrieval deficits (four each with semantic variant primary progressive aphasia, logopenic variant primary progressive aphasia, and Alzheimer's disease, amnestic presentation) and their family members participated in a 6-week intervention that aimed to increase access to different word classes (nouns, verbs, and adjectives) through a strategic self-cueing approach. Generalization was actively facilitated through strategy practice in connected speech. Repeated baselines of picture naming and connected speech were conducted prior to intervention and repeated immediately post and at 6 weeks following intervention. Results All three diagnostic groups showed significant improvements in naming performance post-intervention for all word classes and for both treated and untreated items, demonstrating consistent treatment effectiveness and generalization at the word level. No changes in the informativeness or efficiency of connected speech were found. Conclusions Despite heterogeneity across participants, widespread evidence of both treatment effects and generalization to untreated items was found for all diagnostic groups and word classes. The consistent within-level generalization across all groups is explored here in relation to optimization of strategy use through incorporation of cognitive scaffolds, strategic practice at the connected speech level, and the inclusion of family members. The absence of across-level generalization to connected speech is also explored. Supplemental Material https://doi.org/10.23641/asha.14219771

Treatment for Lexical Retrieval Impairments in Primary Progressive Aphasia: A Research Update with Implications for Clinical Practice

2018 ◽  
Vol 39 (03) ◽  
pp. 242-256 ◽  
Author(s):  
Karen Croot
Keyword(s):  
Clinical Practice ◽  
Clinical Decision Making ◽  
Primary Progressive Aphasia ◽  
Clinical Decision ◽  
Lexical Retrieval ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Behavioral Studies ◽  
Long Term Treatment

AbstractLexical retrieval impairments (also known as anomia or word-finding deficits) are an early and prominent symptom in primary progressive aphasia (PPA), causing distress and frustration to individuals with PPA and their communication partners, and prompting research on lexical retrieval treatment. This paper reviews the research on lexical retrieval treatment in PPA from the earliest reports in the 1990s to early 2018 and considers the implications of this research for clinical practice. The number of published studies has increased markedly over the past decade, consisting primarily of behavioral studies, with rapid recent growth in noninvasive brain stimulation studies. Five general treatment techniques were identified in the behavioral studies, described here as standard naming treatment, Look, Listen, Repeat treatment, cueing hierarchies, semantically focused treatments, and lexical retrieval in context. Across techniques, behavioral studies targeting difficult-to-retrieve items typically report immediate gains, and there is evidence these gains can be maintained over months to years by some participants who continue with long-term treatment. There is also evidence that prophylactic treatment supports retrieval of treated items compared with untreated items. There is limited evidence for generalization of treatment to untreated items, suggesting the primary aim of lexical retrieval treatment in this population is to maintain retrieval of a core vocabulary for as long as possible. Language and cognitive assessment and piloting of the intended treatment can inform decisions about treatment selection and participant suitability for long-term lexical retrieval treatment. The paper concludes with some questions to guide clinical decision making about whether to implement or continue with a behavioral lexical retrieval treatment.

Mobile technology to support lexical retrieval during activity retell in primary progressive aphasia

Aphasiology ◽  
2018 ◽  
Vol 32 (6) ◽  
pp. 666-692 ◽  
Author(s):  
Aimee Mooney ◽  
Steven Bedrick ◽  
Glory Noethe ◽  
Scott Spaulding ◽  
Melanie Fried-Oken
Keyword(s):  
Mobile Technology ◽  
Primary Progressive Aphasia ◽  
Lexical Retrieval ◽  
Progressive Aphasia ◽  
Primary Progressive

P3-220: The Mild Cognitive Impairment of Primary Progressive Aphasia: A Case Series

2016 ◽  
Vol 12 ◽  
pp. P909-P910
Author(s):  
Jessica Powell ◽  
James Lendrum ◽  
Rosalind Huff ◽  
Christine Belden ◽  
Marwan N. Sabbagh
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Case Series ◽  
Primary Progressive Aphasia ◽  
Progressive Aphasia ◽  
Primary Progressive

scholarly journals Behavioral and Pharmacological Treatment of Lexical-Semantic Deficits in a Single Patient With Primary Progressive Aphasia

1995 ◽  
Vol 4 (4) ◽  
pp. 76-87 ◽  
Author(s):  
Malcolm R. McNeil ◽  
Steven L. Small ◽  
Robert J. Masterson ◽  
Tepanta R. D. Fossett
Keyword(s):  
Pharmacological Treatment ◽  
Behavioral Treatment ◽  
Primary Progressive Aphasia ◽  
Lexical Retrieval ◽  
Baseline Design ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Lexical Semantic ◽  
Positive Effects ◽  
Extended Practice

In the context of a hybrid multiple-baseline design, this study demonstrated the positive effects of a behavioral + pharmacological (dextroamphetamine) treatment for lexical-semantic deficits in an individual with primary progressive aphasia (PPA). Behavioral treatment entailed application of a cuing hierarchy to predicative adjectives in order to facilitate lexical retrieval. Treatment was effective for both antonym and synonym adjectives, although extended practice was required to achieve criterion. Generalization to nontreated adjectives, verbs, and prepositions was observed, and maintenance was difficult to disambiguate from the progressive nature of the disease. It was proposed that the mechanisms of activation and inhibition were responsible for improved performance. Differential effects between behavioral and behavioral + pharmacological treatment were not observed.

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