Altered white matter connectivity as a neural substrate for social impairment in Autism Spectrum Disorder

Cortex ◽  
2015 ◽  
Vol 62 ◽  
pp. 158-181 ◽  
Author(s):  
Stephanie H. Ameis ◽  
Marco Catani
Keyword(s):  
Autism Spectrum Disorder ◽  
White Matter ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Social Impairment ◽  
Neural Substrate ◽  
White Matter Connectivity

scholarly journals Neural correlates of polygenic risk score for autism spectrum disorders in general population

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Budhachandra Khundrakpam ◽  
Uku Vainik ◽  
Jinnan Gong ◽  
Noor Al-Sharif ◽  
Neha Bhutani ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
White Matter ◽  
General Population ◽  
Cortical Thickness ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Risk Scores ◽  
Polygenic Risk ◽  
Cortical Regions ◽  
White Matter Connectivity

Abstract Autism spectrum disorder is a highly prevalent and highly heritable neurodevelopmental condition, but studies have mostly taken traditional categorical diagnosis approach (yes/no for autism spectrum disorder). In contrast, an emerging notion suggests a continuum model of autism spectrum disorder with a normal distribution of autistic tendencies in the general population, where a full diagnosis is at the severe tail of the distribution. We set out to investigate such a viewpoint by investigating the interaction of polygenic risk scores for autism spectrum disorder and Age2 on neuroimaging measures (cortical thickness and white matter connectivity) in a general population (n = 391, with age ranging from 3 to 21 years from the Pediatric Imaging, Neurocognition and Genetics study). We observed that children with higher polygenic risk for autism spectrum disorder exhibited greater cortical thickness for a large age span starting from 3 years up to ∼14 years in several cortical regions localized in bilateral precentral gyri and the left hemispheric postcentral gyrus and precuneus. In an independent case–control dataset from the Autism Brain Imaging Data Exchange (n = 560), we observed a similar pattern: children with autism spectrum disorder exhibited greater cortical thickness starting from 6 years onwards till ∼14 years in wide-spread cortical regions including (the ones identified using the general population). We also observed statistically significant regional overlap between the two maps, suggesting that some of the cortical abnormalities associated with autism spectrum disorder overlapped with brain changes associated with genetic vulnerability for autism spectrum disorder in healthy individuals. Lastly, we observed that white matter connectivity between the frontal and parietal regions showed significant association with polygenic risk for autism spectrum disorder, indicating that not only the brain structure, but the white matter connectivity might also show a predisposition for the risk of autism spectrum disorder. Our findings showed that the fronto-parietal thickness and connectivity are dimensionally related to genetic risk for autism spectrum disorder in general population and are also part of the cortical abnormalities associated with autism spectrum disorder. This highlights the necessity of considering continuum models in studying the aetiology of autism spectrum disorder using polygenic risk scores and multimodal neuroimaging.

scholarly journals Identification of infants at high‐risk for autism spectrum disorder using multiparameter multiscale white matter connectivity networks

2015 ◽  
Vol 36 (12) ◽  
pp. 4880-4896 ◽  
Author(s):  
Yan Jin ◽  
Chong‐Yaw Wee ◽  
Feng Shi ◽  
Kim‐Han Thung ◽  
Dong Ni ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
White Matter ◽  
High Risk ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
White Matter Connectivity

scholarly journals Relationship Between Cortical Gyrification, White Matter Connectivity, and Autism Spectrum Disorder

2016 ◽  
Vol 26 (7) ◽  
pp. 3297-3309 ◽  
Author(s):  
C. Ecker ◽  
D. Andrews ◽  
F. Dell'Acqua ◽  
E. Daly ◽  
C. Murphy ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
White Matter ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
White Matter Connectivity

Altered white matter fractional anisotropy and social impairment in children with autism spectrum disorder

2010 ◽  
Vol 1362 ◽  
pp. 141-149 ◽  
Author(s):  
Madoka Noriuchi ◽  
Yoshiaki Kikuchi ◽  
Takashi Yoshiura ◽  
Ryutaro Kira ◽  
Hiroshi Shigeto ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
White Matter ◽  
Fractional Anisotropy ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Social Impairment

scholarly journals Alterations of White Matter Connectivity in Preschool Children with Autism Spectrum Disorder

Radiology ◽  
2018 ◽  
Vol 288 (1) ◽  
pp. 209-217 ◽  
Author(s):  
Shi-Jun Li ◽  
Yi Wang ◽  
Long Qian ◽  
Gang Liu ◽  
Shuang-Feng Liu ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Preschool Children ◽  
White Matter ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
White Matter Connectivity

Dysfunction in interpersonal neural synchronization as a mechanism for social impairment in autism spectrum disorder

2021 ◽  
Author(s):  
Laura E. Quiñones‐Camacho ◽  
Frank A. Fishburn ◽  
Katherine Belardi ◽  
Diane L. Williams ◽  
Theodore J. Huppert ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Social Impairment ◽  
Neural Synchronization

Diametrical relationship between gray and white matter volumes in autism spectrum disorder and schizophrenia

2016 ◽  
Vol 11 (6) ◽  
pp. 1823-1835 ◽  
Author(s):  
Serge A. Mitelman ◽  
Marie-Cecile Bralet ◽  
M. Mehmet Haznedar ◽  
Eric Hollander ◽  
Lina Shihabuddin ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
White Matter ◽  
Autism Spectrum ◽  
Spectrum Disorder
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