Evidence for two distinct sleep-related long-term memory consolidation processes

Cortex ◽  
2015 ◽  
Vol 63 ◽  
pp. 68-78 ◽  
Author(s):  
Monika Schönauer ◽  
Melanie Grätsch ◽  
Steffen Gais
Keyword(s):  
Memory Consolidation ◽  
Long Term Memory ◽  
Term Memory

Notch signalling becomes transiently attenuated during long-term memory consolidation in adult Wistar rats

2007 ◽  
Vol 88 (3) ◽  
pp. 342-351 ◽  
Author(s):  
Lisa Conboy ◽  
Claire M. Seymour ◽  
Marco P. Monopoli ◽  
Niamh C. O’Sullivan ◽  
Keith J. Murphy ◽  
...  
Keyword(s):  
Memory Consolidation ◽  
Wistar Rats ◽  
Notch Signalling ◽  
Long Term Memory ◽  
Term Memory

scholarly journals The amnestic agent anisomycin disrupts intrinsic membrane properties of hippocampal neurons via a loss of cellular energetics

2019 ◽  
Vol 122 (3) ◽  
pp. 1123-1135 ◽  
Author(s):  
C. J. Scavuzzo ◽  
M. J. LeBlancq ◽  
F. Nargang ◽  
H. Lemieux ◽  
T. J. Hamilton ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Mitochondrial Function ◽  
Neural Activity ◽  
Memory Consolidation ◽  
Hippocampal Neurons ◽  
Membrane Properties ◽  
Long Term Memory ◽  
Term Memory ◽  
Cellular Energetics

The nearly axiomatic idea that de novo protein synthesis is necessary for long-term memory consolidation is based heavily on behavioral studies using translational inhibitors such as anisomycin. Although inhibiting protein synthesis has been shown to disrupt the expression of memory, translational inhibitors also have been found to profoundly disrupt basic neurobiological functions, including the suppression of ongoing neural activity in vivo. In the present study, using transverse hippocampal brain slices, we monitored the passive and active membrane properties of hippocampal CA1 pyramidal neurons using intracellular whole cell recordings during a brief ~30-min exposure to fast-bath-perfused anisomycin. Anisomycin suppressed protein synthesis to 46% of control levels as measured using incorporation of radiolabeled amino acids and autoradiography. During its application, anisomycin caused a significant depolarization of the membrane potential, without any changes in apparent input resistance or membrane time constant. Anisomycin-treated neurons also showed significant decreases in firing frequencies and spike amplitudes, and showed increases in spike width across spike trains, without changes in spike threshold. Because these changes indicated a loss of cellular energetics contributing to maintenance of ionic gradients across the membrane, we confirmed that anisomycin impaired mitochondrial function by reduced staining with 2,3,5-triphenyltetrazolium chloride and also impaired cytochrome c oxidase (complex IV) activity as indicated through high-resolution respirometry. These findings emphasize that anisomycin-induced alterations in neural activity and metabolism are a likely consequence of cell-wide translational inhibition. Critical reevaluation of studies using translational inhibitors to promote the protein synthesis dependent idea of long-term memory is absolutely necessary. NEW & NOTEWORTHY Memory consolidation is thought to be dependent on the synthesis of new proteins because translational inhibitors produce amnesia when administered just after learning. However, these agents also disrupt basic neurobiological functions. We show that blocking protein synthesis disrupts basic membrane properties of hippocampal neurons that correspond to induced disruptions of mitochondrial function. It is likely that translational inhibitors cause amnesia through their disruption of neural activity as a result of dysfunction of intracellular energetics.

scholarly journals Transient relay function of midline thalamic nuclei during long-term memory consolidation in humans

2015 ◽  
Vol 22 (10) ◽  
pp. 527-531 ◽  
Author(s):  
Jan-Willem Thielen ◽  
Atsuko Takashima ◽  
Femke Rutters ◽  
Indira Tendolkar ◽  
Guillén Fernández
Keyword(s):  
Memory Consolidation ◽  
Long Term Memory ◽  
Thalamic Nuclei ◽  
Term Memory

β1-and β2-adrenoceptors in hippocampal CA3 region are required for long-term memory consolidation in rats

2015 ◽  
Vol 1627 ◽  
pp. 109-118 ◽  
Author(s):  
Jian Zheng ◽  
Fei Luo ◽  
Nan-nan Guo ◽  
Zong-yue Cheng ◽  
Bao-ming Li
Keyword(s):  
Memory Consolidation ◽  
Long Term Memory ◽  
Term Memory ◽  
Hippocampal Ca3 ◽  
Ca3 Region

scholarly journals METTL3-mediated N6-methyladenosine mRNA modification enhances long-term memory consolidation

Cell Research ◽  
2018 ◽  
Vol 28 (11) ◽  
pp. 1050-1061 ◽  
Author(s):  
Zeyu Zhang ◽  
Meng Wang ◽  
Dongfang Xie ◽  
Zenghui Huang ◽  
Lisha Zhang ◽  
...  
Keyword(s):  
Memory Consolidation ◽  
Long Term Memory ◽  
Term Memory

Hippocampal Interictal Spikes during Sleep Impact Long‐Term Memory Consolidation

2020 ◽  
Vol 87 (6) ◽  
pp. 976-987 ◽  
Author(s):  
Isabelle Lambert ◽  
Eve Tramoni‐Negre ◽  
Stanislas Lagarde ◽  
Nicolas Roehri ◽  
Bernard Giusiano ◽  
...  
Keyword(s):  
Memory Consolidation ◽  
Long Term Memory ◽  
Interictal Spikes ◽  
Term Memory
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