scholarly journals Aberrant functional connectivity in Papez circuit correlates with memory performance in cognitively intact middle-aged APOE4 carriers

Cortex ◽  
2014 ◽  
Vol 57 ◽  
pp. 167-176 ◽  
Author(s):  
Wenjun Li ◽  
Piero G. Antuono ◽  
Chunming Xie ◽  
Gang Chen ◽  
Jennifer L. Jones ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Memory Performance ◽  
Middle Aged ◽  
Papez Circuit ◽  
Cognitively Intact ◽  
With Memory

scholarly journals Early stages of tau pathology and its associations with functional connectivity, atrophy and memory

Brain ◽  
2021 ◽  
Author(s):  
David Berron ◽  
Jacob W Vogel ◽  
Philip S Insel ◽  
Joana B Pereira ◽  
Long Xie ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Entorhinal Cortex ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Memory Impairment ◽  
Memory Performance ◽  
Hippocampal Atrophy ◽  
Tau Pathology ◽  
Β Amyloid ◽  
With Memory

Abstract In Alzheimer’s disease, postmortem studies have shown that the first cortical site where neurofibrillary tangles appear is the transentorhinal region, a subregion within the medial temporal lobe that largely overlaps with area 35, and the entorhinal cortex. Here we used tau-PET imaging to investigate the sequence of tau pathology progression within the human medial temporal lobe and across regions in the posterior-medial system. Our objective was to study how medial temporal tau is related to functional connectivity, regional atrophy, and memory performance. We included 215 β-amyloid negative cognitively unimpaired, 81 β-amyloid positive cognitively unimpaired and 87 β-amyloid positive individuals with mild cognitive impairment, who each underwent [18]F-RO948 tau and [18]F-flutemetamol amyloid PET imaging, structural T1-MRI and memory assessments as part of the Swedish BioFINDER-2 study. First, event-based modelling revealed that the entorhinal cortex and area 35 show the earliest signs of tau accumulation followed by the anterior and posterior hippocampus, area 36 and the parahippocampal cortex. In later stages, tau accumulation became abnormal in neocortical temporal and finally parietal brain regions. Second, in cognitively unimpaired individuals, increased tau load was related to local atrophy in the entorhinal cortex, area 35 and the anterior hippocampus and tau load in several anterior medial temporal lobe subregions was associated with distant atrophy of the posterior hippocampus. Tau load, but not atrophy, in these regions was associated with lower memory performance. Further, tau-related reductions in functional connectivity in critical networks between the medial temporal lobe and regions in the posterior-medial system were associated with this early memory impairment. Finally, in patients with mild cognitive impairment, the association of tau load in the hippocampus with memory performance was partially mediated by posterior hippocampal atrophy. In summary, our findings highlight the progression of tau pathology across medial temporal lobe subregions and its disease-stage specific association with memory performance. While tau pathology might affect memory performance in cognitively unimpaired individuals via reduced functional connectivity in critical medial temporal lobe-cortical networks, memory impairment in mild cognitively impaired patients is associated with posterior hippocampal atrophy.

scholarly journals Increased Hippocampal Default Mode Synchronization during Rest in Middle-Aged and Elderly APOE  4 Carriers: Relationships with Memory Performance

2011 ◽  
Vol 31 (21) ◽  
pp. 7775-7783 ◽  
Author(s):  
E. T. Westlye ◽  
A. Lundervold ◽  
H. Rootwelt ◽  
A. J. Lundervold ◽  
L. T. Westlye
Keyword(s):  
Memory Performance ◽  
Middle Aged ◽  
Default Mode ◽  
Mode Synchronization ◽  
With Memory

The Long Arm of Childhood in China: Early-Life Conditions and Cognitive Function Among Middle-Aged and Older Adults

2017 ◽  
Vol 30 (8) ◽  
pp. 1319-1344 ◽  
Author(s):  
Zhenmei Zhang ◽  
Jinyu Liu ◽  
Lydia Li ◽  
Hongwei Xu
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Memory Performance ◽  
Word Recall ◽  
Middle Aged ◽  
Urban Residence ◽  
Childhood Conditions ◽  
Early Life Conditions ◽  
Childhood Socioeconomic Status ◽  
With Memory

Objective: This study examined the association between childhood conditions and cognitive function among middle-aged and older adults in China. Method: We analyzed data from the 2011 China Health and Retirement Longitudinal Study ( N = 11,868). Cognitive function was measured by word recall, a test of episodic memory. We examined the association between childhood conditions and cognitive function among the middle-aged (45-59 years) and the older (60 years and older) adults separately, using multilevel linear regressions. Results: Indicators of childhood socioeconomic status (SES) and nutrition were significantly associated with memory performance among the middle-aged and the older adults in China. Adulthood SES, education in particular, accounted for some but not all the associations. The protective effect of childhood urban residence was stronger for middle-aged women than for middle-aged men. Discussion: Childhood conditions are significantly associated with mid- to late-life cognitive function in China. The strengths of the associations may vary by gender and cohort.

Association of the apolipoprotein E genotype with memory performance and executive functioning in cognitively intact elderly.

2015 ◽  
Vol 29 (3) ◽  
pp. 382-387 ◽  
Author(s):  
Tobias Luck ◽  
Francisca S. Then ◽  
Melanie Luppa ◽  
Matthias L. Schroeter ◽  
Katrin Arélin ◽  
...  
Keyword(s):  
Executive Functioning ◽  
Apolipoprotein E ◽  
Memory Performance ◽  
Cognitively Intact ◽  
With Memory ◽  
Apolipoprotein E Genotype

scholarly journals The more you know: Investigating why adults get a bigger memory boost from semantic congruency than children

2018 ◽  
Author(s):  
Wei-Chun Wang ◽  
Simona Ghetti ◽  
Garvin Brod ◽  
Silvia A. Bunge
Keyword(s):  
Functional Connectivity ◽  
Prior Knowledge ◽  
Source Memory ◽  
Multivariate Analyses ◽  
Memory Performance ◽  
Memory Task ◽  
Neural Substrates ◽  
Brain Regions ◽  
Age Related ◽  
With Memory

AbstractHumans possess the capacity to employ prior knowledge in the service of our ability to remember; thus, memory is oftentimes superior for information that is semantically congruent with our prior knowledge. This congruency benefit grows during development, but little is understood about neurodevelopmental differences that underlie this growth. Here, we sought to explore the brain mechanisms underlying these phenomena. To this end, we examined the neural substrates of semantically congruent vs. incongruent item-context associations in 116 children and 25 young adults who performed encoding and retrieval tasks during functional MRI data collection. Participants encoded item-context pairs by judging whether an item belonged in a scene. Episodic memory was then tested with a source memory task. Consistent with prior work, source memory accuracy improved with age, and was greater for congruent than incongruent pairs; further, this congruency benefit was greater in adults than children. Age-related differences were observed across univariate, functional connectivity, and multivariate analyses, particularly in lateral prefrontal cortex (PFC). In sum, our results revealed two general age differences. First, left ventrolateral/rostrolateral PFC exhibited age-related increases in univariate activity, as well as greater functional connectivity with temporal regions during the processing of congruency. Second, right rostrolateral PFC activation was associated with successfully encoded congruent associations in adults, but not children. Finally, multivariate analyses provided evidence for stronger veridical memory in adults than children in right ventrolateral PFC. These effects in right lateral PFC were significantly correlated with memory performance, implicating them in the process of remembering congruent associations. These results connect brain regions associated with top-down control in the congruency benefit and age-related improvements therein.

Differential functional connectivity responses to iTBS in young and elder subjects. Association with memory performance

2017 ◽  
Vol 10 (2) ◽  
pp. 443-446
Author(s):  
K. Abellaneda-Pérez ◽  
L. Vaqué-Alcázar ◽  
P. Martín-Trias ◽  
E. Solana ◽  
D. Vidal-Piñeiro ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Memory Performance ◽  
With Memory

Functional connectivity during light sleep is correlated with memory performance for face–location associations

NeuroImage ◽  
2011 ◽  
Vol 57 (1) ◽  
pp. 262-270 ◽  
Author(s):  
Eelco V. van Dongen ◽  
Atsuko Takashima ◽  
Markus Barth ◽  
Guillén Fernández
Keyword(s):  
Functional Connectivity ◽  
Memory Performance ◽  
Face Location ◽  
With Memory ◽  
Light Sleep

scholarly journals Connectome Signatures of Hyperexcitation in Cognitively Intact Middle-Aged Female APOE-ε4 Carriers

2020 ◽  
Vol 30 (12) ◽  
pp. 6350-6362
Author(s):  
Igor Fortel ◽  
Laura E Korthauer ◽  
Zachery Morrissey ◽  
Liang Zhan ◽  
Olusola Ajilore ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Memory Performance ◽  
Carrier Status ◽  
Significant Shift ◽  
Middle Aged ◽  
Apoe Ε4 ◽  
Virtual Morris Water Task ◽  
Cognitively Intact ◽  
Female Carriers

Abstract Synaptic dysfunction is hypothesized to be one of the earliest brain changes in Alzheimer’s disease, leading to “hyperexcitability” in neuronal circuits. In this study, we evaluated a novel hyperexcitation indicator (HI) for each brain region using a hybrid resting-state structural connectome to probe connectome-level excitation–inhibition balance in cognitively intact middle-aged apolipoprotein E (APOE) ε4 carriers with noncarriers (16 male/22 female in each group). Regression with three-way interactions (sex, age, and APOE-ε4 carrier status) to assess the effect of APOE-ε4 on excitation–inhibition balance within each sex and across an age range of 40–60 years yielded a significant shift toward higher HI in female carriers compared with noncarriers (beginning at 50 years). Hyperexcitation was insignificant in the male group. Further, in female carriers the degree of hyperexcitation exhibited significant positive correlation with working memory performance (evaluated via a virtual Morris Water task) in three regions: the left pars triangularis, left hippocampus, and left isthmus of cingulate gyrus. Increased excitation of memory-related circuits may be evidence of compensatory recruitment of neuronal resources for memory-focused activities. In sum, our results are consistent with known Alzheimer’s disease sex differences; in that female APOE-ε4 carriers have globally disrupted excitation–inhibition balance that may confer greater vulnerability to disease neuropathology.

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