Contribution of the right intraparietal sulcus to numerosity and length processing: An fMRI-guided TMS study

Cortex ◽  
2012 ◽  
Vol 48 (5) ◽  
pp. 623-629 ◽  
Author(s):  
Valérie Dormal ◽  
Michael Andres ◽  
Mauro Pesenti
Keyword(s):  
Intraparietal Sulcus ◽  
The Right

scholarly journals Disentangling Mathematics from Executive Functions by Investigating Unique Functional Connectivity Patterns Predictive of Mathematics Ability

2019 ◽  
Vol 31 (4) ◽  
pp. 560-573 ◽  
Author(s):  
Kenny Skagerlund ◽  
Taylor Bolt ◽  
Jason S. Nomi ◽  
Mikael Skagenholt ◽  
Daniel Västfjäll ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Inferior Frontal Gyrus ◽  
Premotor Cortex ◽  
Mathematical Ability ◽  
Angular Gyrus ◽  
Intraparietal Sulcus ◽  
Supramarginal Gyrus ◽  
Connectivity Patterns ◽  
The Right

What are the underlying neurocognitive mechanisms that give rise to mathematical competence? This study investigated the relationship between tests of mathematical ability completed outside the scanner and resting-state functional connectivity (FC) of cytoarchitectonically defined subdivisions of the parietal cortex in adults. These parietal areas are also involved in executive functions (EFs). Therefore, it remains unclear whether there are unique networks for mathematical processing. We investigate the neural networks for mathematical cognition and three measures of EF using resting-state fMRI data collected from 51 healthy adults. Using 10 ROIs in seed to whole-brain voxel-wise analyses, the results showed that arithmetical ability was correlated with FC between the right anterior intraparietal sulcus (hIP1) and the left supramarginal gyrus and between the right posterior intraparietal sulcus (hIP3) and the left middle frontal gyrus and the right premotor cortex. The connection between the posterior portion of the left angular gyrus and the left inferior frontal gyrus was also correlated with mathematical ability. Covariates of EF eliminated connectivity patterns with nodes in inferior frontal gyrus, angular gyrus, and middle frontal gyrus, suggesting neural overlap. Controlling for EF, we found unique connections correlated with mathematical ability between the right hIP1 and the left supramarginal gyrus and between hIP3 bilaterally to premotor cortex bilaterally. This is partly in line with the “mapping hypothesis” of numerical cognition in which the right intraparietal sulcus subserves nonsymbolic number processing and connects to the left parietal cortex, responsible for calculation procedures. We show that FC within this circuitry is a significant predictor of math ability in adulthood.

The Neuroanatomy of Visual Enumeration: Differentiating Necessary Neural Correlates for Subitizing versus Counting in a Neuropsychological Voxel-based Morphometry Study

2012 ◽  
Vol 24 (4) ◽  
pp. 948-964 ◽  
Author(s):  
Nele Demeyere ◽  
Pia Rotshtein ◽  
Glyn W. Humphreys
Keyword(s):  
Occipital Cortex ◽  
Neural Correlates ◽  
Intraparietal Sulcus ◽  
Voxel Based Morphometry ◽  
Large Numbers ◽  
Subitizing Range ◽  
Response Slope ◽  
Left Posterior ◽  
Visual Enumeration ◽  
The Right

This study is the first to assess lesion–symptom relations for subitizing and counting impairments in a large sample of neuropsychological patients (41 patients) using an observer-independent voxel-based approach. We tested for differential effects of enumerating small versus large numbers of items while controlling for hemianopia and visual attention deficits. Overall impairments in the enumeration of any numbers (small or large) were associated with an extended network, including bilateral occipital and fronto-parietal regions. Within this network, severe impairments in accuracy when enumerating small sets of items (in the subitizing range) were associated with damage to the left posterior occipital cortex, bilateral lateral occipital and right superior frontal cortices. Lesions to the right calcarine extending to the precuneus led to patients serially counting even small numbers of items (indicated by a steep response slope), again demonstrating an impaired subitizing ability. In contrast, impairments in counting large numerosities were associated with damage to the left intraparietal sulcus. The data support the argument for some distinctive processes and neural areas necessary to support subitization and counting with subitizing relying on processes of posterior occipital cortex and with counting associated with processing in the parietal cortex.

scholarly journals The Commonality of Neural Networks for Verbal and Visual Short-term Memory

2010 ◽  
Vol 22 (11) ◽  
pp. 2570-2593 ◽  
Author(s):  
Steve Majerus ◽  
Arnaud D'Argembeau ◽  
Trecy Martinez Perez ◽  
Sanaâ Belayachi ◽  
Martial Van der Linden ◽  
...  
Keyword(s):  
Short Term Memory ◽  
Serial Order ◽  
Item Information ◽  
Intraparietal Sulcus ◽  
Short Term ◽  
Term Memory ◽  
Modality Effects ◽  
Visual Short Term Memory ◽  
Processing And Storage ◽  
The Right

Although many neuroimaging studies have considered verbal and visual short-term memory (STM) as relying on neurally segregated short-term buffer systems, the present study explored the existence of shared neural correlates supporting verbal and visual STM. We hypothesized that networks involved in attentional and executive processes, as well as networks involved in serial order processing, underlie STM for both verbal and visual list information, with neural specificity restricted to sensory areas involved in processing the specific items to be retained. Participants were presented sequences of nonwords or unfamiliar faces, and were instructed to maintain and recognize order or item information. For encoding and retrieval phases, null conjunction analysis revealed an identical fronto-parieto-cerebellar network comprising the left intraparietal sulcus, bilateral dorsolateral prefrontal cortex, and the bilateral cerebellum, irrespective of information type and modality. A network centered around the right intraparietal sulcus supported STM for order information, in both verbal and visual modalities. Modality-specific effects were observed in left superior temporal and mid-fusiform areas associated with phonological and orthographic processing during the verbal STM tasks, and in right hippocampal and fusiform face processing areas during the visual STM tasks, wherein these modality effects were most pronounced when storing item information. The present results suggest that STM emerges from the deployment of modality-independent attentional and serial ordering processes toward sensory networks underlying the processing and storage of modality-specific item information.

Mode-dependent and mode-independent representations of numerosity in the right intraparietal sulcus

NeuroImage ◽  
2010 ◽  
Vol 52 (4) ◽  
pp. 1677-1686 ◽  
Author(s):  
Valérie Dormal ◽  
Michael Andres ◽  
Giulia Dormal ◽  
Mauro Pesenti
Keyword(s):  
Intraparietal Sulcus ◽  
The Right

Right parietal cortex and calculation processing: intraoperative functional mapping of multiplication and addition in patients affected by a brain tumor

2013 ◽  
Vol 119 (5) ◽  
pp. 1107-1111 ◽  
Author(s):  
Alessandro Della Puppa ◽  
Serena De Pellegrin ◽  
Elena d'Avella ◽  
Giorgio Gioffrè ◽  
Marina Munari ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Parietal Cortex ◽  
Parietal Lobe ◽  
Tumor Resection ◽  
Functional Mapping ◽  
Awake Surgery ◽  
Intraparietal Sulcus ◽  
Functional Sites ◽  
Parietal Area ◽  
The Right

Object The role of parietal areas in number processing is well known. The significance of intraoperative functional mapping of these areas has been only partially explored, however, and only a few discordant data are available in the surgical literature with regard to the right parietal lobe. The purpose of this study was to evaluate the clinical impact of simple calculation in cortical electrostimulation of right-handed patients affected by a right parietal brain tumor. Methods Calculation mapping in awake surgery was performed in 3 right-handed patients affected by high-grade gliomas located in the right parietal lobe. Preoperatively, none of the patients presented with calculation deficits. In all 3 cases, after sensorimotor and language mapping, cortical and intraparietal sulcus areas involved in single-digit multiplication and addition calculations were mapped using bipolar electrostimulation. Results In all patients, different sites of the right parietal cortex, mainly in the inferior lobule, were detected as being specifically related to calculation (multiplication or addition). In 2 patients the intraparietal sulcus was functionally specific for multiplication. No functional sites for language were detected. All sites functional for calculation were spared during tumor resection, which was complete in all cases without postoperative neurological deficits. Conclusions These findings provide intraoperative data in support of an anatomofunctional organization for multiplication and addition within the right parietal area. Furthermore, the study shows the potential clinical relevance of intraoperative mapping of calculation in patients undergoing surgery in the right parietal area. Further and larger studies are needed to confirm these data and assess whether mapped areas are effectively essential for function.

scholarly journals Grasping with the Press of a Button: Grasp-selective Responses in the Human Anterior Intraparietal Sulcus Depend on Nonarbitrary Causal Relationships between Hand Movements and End-effector Actions

2015 ◽  
Vol 27 (6) ◽  
pp. 1146-1160 ◽  
Author(s):  
Scott H. Frey ◽  
Marc Hansen ◽  
Noah Marchal
Keyword(s):  
Premotor Cortex ◽  
Hand Movements ◽  
Cerebellar Hemisphere ◽  
Intraparietal Sulcus ◽  
Causal Relationships ◽  
National Academy Of Sciences ◽  
End Effector ◽  
Reach And Grasp ◽  
The Right ◽  
Anterior Intraparietal Sulcus

Evidence implicates ventral parieto-premotor cortices in representing the goal of grasping independent of the movements or effectors involved [Umilta, M. A., Escola, L., Intskirveli, I., Grammont, F., Rochat, M., Caruana, F., et al. When pliers become fingers in the monkey motor system. Proceedings of the National Academy of Sciences, U.S.A., 105, 2209–2213, 2008; Tunik, E., Frey, S. H., & Grafton, S. T. Virtual lesions of the anterior intraparietal area disrupt goal-dependent on-line adjustments of grasp. Nature Neuroscience, 8, 505–511, 2005]. Modern technologies that enable arbitrary causal relationships between hand movements and tool actions provide a strong test of this hypothesis. We capitalized on this unique opportunity by recording activity with fMRI during tasks in which healthy adults performed goal-directed reach and grasp actions manually or by depressing buttons to initiate these same behaviors in a remotely located robotic arm (arbitrary causal relationship). As shown previously [Binkofski, F., Dohle, C., Posse, S., Stephan, K. M., Hefter, H., Seitz, R. J., et al. Human anterior intraparietal area subserves prehension: A combined lesion and functional MRI activation study. Neurology, 50, 1253–1259, 1998], we detected greater activity in the vicinity of the anterior intraparietal sulcus (aIPS) during manual grasp versus reach. In contrast to prior studies involving tools controlled by nonarbitrarily related hand movements [Gallivan, J. P., McLean, D. A., Valyear, K. F., & Culham, J. C. Decoding the neural mechanisms of human tool use. Elife, 2, e00425, 2013; Jacobs, S., Danielmeier, C., & Frey, S. H. Human anterior intraparietal and ventral premotor cortices support representations of grasping with the hand or a novel tool. Journal of Cognitive Neuroscience, 22, 2594–2608, 2010], however, responses within the aIPS and premotor cortex exhibited no evidence of selectivity for grasp when participants employed the robot. Instead, these regions showed comparable increases in activity during both the reach and grasp conditions. Despite equivalent sensorimotor demands, the right cerebellar hemisphere displayed greater activity when participants initiated the robot's actions versus when they pressed a button known to be nonfunctional and watched the very same actions undertaken autonomously. This supports the hypothesis that the cerebellum predicts the forthcoming sensory consequences of volitional actions [Blakemore, S. J., Frith, C. D., & Wolpert, D. M. The cerebellum is involved in predicting the sensory consequences of action. NeuroReport, 12, 1879–1884, 2001]. We conclude that grasp-selective responses in the human aIPS and premotor cortex depend on the existence of nonarbitrary causal relationships between hand movements and end-effector actions.

scholarly journals Increased functional connectivity of the intraparietal sulcus underlies the attenuation of numerosity estimations for self-generated words

2020 ◽  
Author(s):  
Giedre Stripeikyte ◽  
Michael Pereira ◽  
Giulio Rognini ◽  
Jevita Potheegadoo ◽  
Olaf Blanke ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Cognitive Functions ◽  
Supplementary Motor Area ◽  
Superior Temporal Gyrus ◽  
Intraparietal Sulcus ◽  
Neural Responses ◽  
Passive Condition ◽  
Sensorimotor Processing ◽  
Active Condition ◽  
The Right

ABSTRACTPrevious studies have shown that self-generated stimuli in auditory, visual, and somatosensory domains are attenuated, producing decreased behavioral and neural responses compared to the same stimuli that are externally generated. Yet, whether such attenuation also occurs for higher-level cognitive functions beyond sensorimotor processing remains unknown. In this study, we assessed whether cognitive functions such as numerosity estimations are subject to attenuation. We designed a task allowing the controlled comparison of numerosity estimations for self (active condition) and externally (passive condition) generated words. Our behavioral results showed a larger underestimation of self-compared to externally-generated words, suggesting that numerosity estimations for self-generated words are attenuated. Moreover, the linear relationship between the reported and actual number of words was stronger for self-generated words, although the ability to track errors about numerosity estimations was similar across conditions. Neuroimaging results revealed that numerosity underestimation involved increased functional connectivity between the right intraparietal sulcus and an extended network (bilateral supplementary motor area, left inferior parietal lobule and left superior temporal gyrus) when estimating the number of self vs. externally generated words. We interpret our results in light of two models of attenuation and discuss their perceptual versus cognitive origins.

scholarly journals Revisiting Previously Searched Locations in Visual Neglect: Role of Right Parietal and Frontal Lesions in Misjudging Old Locations as New

2005 ◽  
Vol 17 (2) ◽  
pp. 340-354 ◽  
Author(s):  
Sabira K. Mannan ◽  
Dominic J. Mort ◽  
Tim L. Hodgson ◽  
Jon Driver ◽  
Christopher Kennard ◽  
...  
Keyword(s):  
Right Hemisphere ◽  
Search Time ◽  
Intraparietal Sulcus ◽  
High Resolution Mri ◽  
Underlying Mechanisms ◽  
The Right ◽  
Frontal Lesions ◽  
First Time ◽  
Abnormal Visual

Right-hemisphere patients with left neglect often demonstrate abnormal visual search, re-examining stimuli to the right while ignoring those to the left. But re-fixations alone do not reveal if patients misjudge whether they have searched a location before. Here, we not only tracked the eye movements of 16 neglect patients during search, but also asked them to click a response button only when they judged they were fixating a target for the very first time. “Re-clicking” on previously found targets would indicate that patients erroneously respond to these as new discoveries. Lesions were mapped with high-resolution MRI. Neglect patients with damage involving the right intraparietal sulcus or right inferior frontal lobe “re-clicked” on previously found targets on the right at a pathological rate, whereas those with medial occipito-temporal lesions did not. For the intraparietal sulcus patients, the probability of erroneous re-clicks on an old target increased with time since first discovering it; whereas for frontal patients it was independent of search time, suggesting different underlying mechanisms in these two types of patient. Re-click deficits correlated with degree of leftward neglect, mainly due to both being severe in intraparietal cases. These results demonstrate that misjudging previously searched locations for new ones can contribute to pathological search in neglect, with potentially different mechanisms being involved in intraparietal versus inferior frontal patients. When combined with a spatial bias to the right, such deficits might explain why many neglect patients often re-examine rightward locations, at the expense of items to their left.

scholarly journals The Right Anterior Intraparietal Sulcus Is Critical for Bimanual Grasping: A TMS Study

2013 ◽  
Vol 24 (10) ◽  
pp. 2591-2603 ◽  
Author(s):  
A. Le ◽  
M. Vesia ◽  
X. Yan ◽  
M. Niemeier ◽  
J. D. Crawford
Keyword(s):  
Intraparietal Sulcus ◽  
The Right ◽  
Bimanual Grasping ◽  
Anterior Intraparietal Sulcus

In search of non-abstract representation of numbers: Maybe on the right track, but still not there

2009 ◽  
Vol 32 (3-4) ◽  
pp. 353-354
Author(s):  
Joseph Tzelgov ◽  
Michal Pinhas
Keyword(s):  
Automatic Processing ◽  
Convergence Zone ◽  
Numerical Representation ◽  
Intraparietal Sulcus ◽  
Abstract Representation ◽  
Parietal Lobes ◽  
The Right

AbstractWe agree that the default numerical representation is best accessed by probing automatic processing. The locus of this representation is apparently at the horizontal intraparietal sulcus (HIPS), the convergence zone of magnitude information. The parietal lobes are the right place to look for non-abstract representation of magnitude, yet the proof for that is still to be found.

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