An fMRI study of the numerical Stroop task in individuals with and without minimal cognitive impairment

Cortex ◽  
2008 ◽  
Vol 44 (9) ◽  
pp. 1248-1255 ◽  
Author(s):  
Liane Kaufmann ◽  
Anja Ischebeck ◽  
Elisabeth Weiss ◽  
Florian Koppelstaetter ◽  
Christian Siedentopf ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Stroop Task ◽  
Fmri Study ◽  
Numerical Stroop Task

Neural correlates of distance and congruity effects in a numerical Stroop task: an event-related fMRI study

NeuroImage ◽  
2005 ◽  
Vol 25 (3) ◽  
pp. 888-898 ◽  
Author(s):  
Liane Kaufmann ◽  
Florian Koppelstaetter ◽  
Margarete Delazer ◽  
Christian Siedentopf ◽  
Paul Rhomberg ◽  
...  
Keyword(s):  
Stroop Task ◽  
Neural Correlates ◽  
Fmri Study ◽  
Numerical Stroop Task

Assessment of the neuronal underpinnings of cognitive impairment in bipolar disorder with a picture encoding paradigm and methodological lessons learnt

2021 ◽  
pp. 026988112110085
Author(s):  
JZ Petersen ◽  
J Macoveanu ◽  
HL Kjærstad ◽  
GM Knudsen ◽  
LV Kessing ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Impairment ◽  
Neuronal Activity ◽  
Cognitive Impairments ◽  
Hierarchical Cluster ◽  
Small Region ◽  
Middle Temporal Gyrus ◽  
Recall Accuracy ◽  
Fmri Study

Background: Mood disorders are often associated with persistent cognitive impairments. However, pro-cognitive treatments are essentially lacking. This is partially because of poor insight into the neurocircuitry abnormalities underlying these deficits and their change with illness progression. Aims: This functional magnetic resonance imaging (fMRI) study investigates the neuronal underpinnings of cognitive impairments and neuronal change after mood episodes in remitted patients with bipolar disorder (BD) using a hippocampus-based picture encoding paradigm. Methods: Remitted patients with BD ( n=153) and healthy controls ( n=52) were assessed with neuropsychological tests and underwent fMRI while performing a strategic picture encoding task. A subgroup of patients ( n=43) were rescanned after 16 months. We conducted data-driven hierarchical cluster analysis of patients’ neuropsychological data and compared encoding-related neuronal activity between the resulting neurocognitive subgroups. For patients with follow-up data, effects of mood episodes were assessed by comparing encoding-related neuronal activity change in BD patients with and without episode(s). Results: Two neurocognitive subgroups were revealed: 91 patients displayed cognitive impairments while 62 patients were cognitively normal. No neuronal activity differences were observed between neurocognitive subgroups within the dorsal cognitive control network or hippocampus. However, exploratory whole-brain analysis revealed lower activity within a small region of middle temporal gyrus in impaired patients, which significantly correlated with poorer neuropsychological performance. No changes were observed in encoding-related neuronal activity or picture recall accuracy with the occurrence of mood episode(s) during the follow-up period. Conclusion: Memory encoding fMRI paradigms may not capture the neuronal underpinnings of cognitive impairment or effects of mood episodes.

scholarly journals Spatial Navigation Impairment Is Associated with Alterations in Subcortical Intrinsic Activity in Mild Cognitive Impairment: A Resting-State fMRI Study

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Zhao Qing ◽  
Weiping Li ◽  
Zuzana Nedelska ◽  
Wenbo Wu ◽  
Fangfang Wang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Spatial Navigation ◽  
Resting State Fmri ◽  
Intrinsic Activity ◽  
Fmri Study ◽  
Computer Based ◽  
Subcortical Regions ◽  
The Right ◽  
Brain Behavior

Impairment of spatial navigation (SN) skills is one of the features of the Alzheimer’s disease (AD) already at the stage of mild cognitive impairment (MCI). We used a computer-based battery of spatial navigation tests to measure the SN performance in 22 MCI patients as well as 21 normal controls (NC). In order to evaluate intrinsic activity in the subcortical regions that may play a role in SN, we measured ALFF, fALFF, and ReHo derived within 14 subcortical regions. We observed reductions of intrinsic activity in MCI patients. We also demonstrated that the MCI versus NC group difference can modulate activity-behavior relationship, that is, the correlation slopes between ReHo and allocentric SN task total errors were significantly different between NC and MCI groups in the right hippocampus (interaction F=4.44, p=0.05), pallidum (F=8.97, p=0.005), and thalamus (F=5.95, p=0.02), which were negative in NC (right hippocampus, r=−0.49; right pallidum, r=−0.50; right thalamus, r=−0.45; all p<0.05) but absent in MCI (right hippocampus, r=0.21; right pallidum, r=0.32; right thalamus r=0.28; all p>0.2). These findings may provide a novel insight of the brain mechanism associated with SN impairment in MCI and indicated a stage specificity of brain-behavior correlation in dementia. This trial is registered with ChiCTR-BRC-17011316.

P3-096 Effects of galantamine challenge on episodic and working memory systems in patients with mild cognitive impairment: an FMRI study

2004 ◽  
Vol 25 ◽  
pp. S381-S382
Author(s):  
Philip Scheltens ◽  
Rutger Goekoop ◽  
Serge A. Rombouts ◽  
Luc Truyen ◽  
Frederik Barkhof
Keyword(s):  
Working Memory ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Memory Systems ◽  
Fmri Study

scholarly journals Impaired Processing of 3D Motion-Defined Faces in Mild Cognitive Impairment and Healthy Aging: An fMRI Study

2012 ◽  
Vol 23 (10) ◽  
pp. 2489-2499 ◽  
Author(s):  
B. Graewe ◽  
R. Lemos ◽  
C. Ferreira ◽  
I. Santana ◽  
R. Farivar ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Healthy Aging ◽  
3D Motion ◽  
Fmri Study

P2-414: Self-appraisal in Alzheimer's disease, mild cognitive impairment and normal aging: An fMRI study

2010 ◽  
Vol 6 ◽  
pp. S440-S441
Author(s):  
Giovanna Zamboni ◽  
Erin Drazich ◽  
Ellen McCulloch ◽  
Irene Tracey ◽  
Gordon Wilcock
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Normal Aging ◽  
Fmri Study
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