scholarly journals Cell signaling regulation by protein phosphorylation: a multivariate, heterogeneous, and context-dependent process

2016 ◽  
Vol 40 ◽  
pp. 185-192 ◽  
Author(s):  
Evan K Day ◽  
Nisha G Sosale ◽  
Matthew J Lazzara
Keyword(s):  
Cell Signaling ◽  
Protein Phosphorylation ◽  
Signaling Regulation ◽  
Dependent Process ◽  
Context Dependent

scholarly journals Interpreting and knowledge mediation in the healthcare setting: What do we really mean by “accuracy”?

2021 ◽  
Vol 11 ◽  
Author(s):  
George Major ◽  
Jemina Napier
Keyword(s):  
Health Information ◽  
Sign Language ◽  
Healthcare Setting ◽  
Systematic Comparison ◽  
Dependent Process ◽  
Context Dependent ◽  
Interpreter Training ◽  
Artificial Nature ◽  
The One ◽  
Robust Evidence

This paper explores the concept of “accuracy” in the context of interpreter-mediated healthcare interaction by reporting on a study of simulated doctor-patient consultations involving professional Australian Sign Language (Auslan)/English interpreters. Wadensjö’s (1998) taxonomy of renditions is used to analyse the ways interpreters convey health information. Our data reveals that interpreters frequently produce reduced and expanded renditions that are not detrimental to the message or the interaction. There has previously been little discussion of how qualified interpreters make these decisions, and we suggest that achieving accuracy in the healthcare setting may be a more dynamic and context-dependent process than previously suggested. While the use of role-plays can on the one hand can be considered a delimiting factor (due to their artificial nature), they also allow a systematic comparison of different interpreters, thus providing more robust evidence for healthcare interpreter training.

scholarly journals Crosstalk between neutrophils and dendritic cells: a context-dependent process

2013 ◽  
Vol 94 (4) ◽  
pp. 671-675 ◽  
Author(s):  
Steffen Schuster ◽  
Benjamin Hurrell ◽  
Fabienne Tacchini-Cottier
Keyword(s):  
Dendritic Cells ◽  
Dependent Process ◽  
Context Dependent

Autocrine loops with positive feedback enable context-dependent cell signaling

2002 ◽  
Vol 282 (3) ◽  
pp. C545-C559 ◽  
Author(s):  
S. Y. Shvartsman ◽  
M. P. Hagan ◽  
A. Yacoub ◽  
P. Dent ◽  
H. S. Wiley ◽  
...  
Keyword(s):  
Growth Factor ◽  
Ionizing Radiation ◽  
Cell Signaling ◽  
Positive Feedback ◽  
Intracellular Signaling ◽  
Mapk Signaling ◽  
Extracellular Medium ◽  
Dependent Cell ◽  
Autocrine Loops ◽  
Context Dependent

We describe a mechanism for context-dependent cell signaling mediated by autocrine loops with positive feedback. We demonstrate that the composition of the extracellular medium can critically influence the intracellular signaling dynamics induced by extracellular stimuli. Specifically, in the epidermal growth factor receptor (EGFR) system, amplitude and duration of mitogen-activated protein kinase (MAPK) activation are modulated by the positive-feedback loop formed by the EGFR, the Ras-MAPK signaling pathway, and a ligand-releasing protease. The signaling response to a transient input is short-lived when most of the released ligand is lost to the cellular microenvironment by diffusion and/or interaction with an extracellular ligand-binding component. In contrast, the response is prolonged or persistent in a cell that is efficient in recapturing the endogenous ligand. To study functional capabilities of autocrine loops, we have developed a mathematical model that accounts for ligand release, transport, binding, and intracellular signaling. We find that context-dependent signaling arises as a result of dynamic interaction between the parts of an autocrine loop. Using the model, we can directly interpret experimental observations on context-dependent responses of autocrine cells to ionizing radiation. In human carcinoma cells, MAPK signaling patterns induced by a short pulse of ionizing radiation can be transient or sustained, depending on cell type and composition of the extracellular medium. On the basis of our model, we propose that autocrine loops in this, and potentially other, growth factor and cytokine systems may serve as modules for context-dependent cell signaling.

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