scholarly journals Actin cytoskeleton in dendritic spine development and plasticity

2016 ◽  
Vol 39 ◽  
pp. 86-92 ◽  
Author(s):  
Wenliang Lei ◽  
Omotola F Omotade ◽  
Kenneth R Myers ◽  
James Q Zheng
Keyword(s):  
Actin Cytoskeleton ◽  
Dendritic Spine ◽  
Spine Development

scholarly journals Molecular Architecture of Synaptic Actin Cytoskeleton in Hippocampal Neurons Reveals a Mechanism of Dendritic Spine Morphogenesis

2010 ◽  
Vol 21 (1) ◽  
pp. 165-176 ◽  
Author(s):  
Farida Korobova ◽  
Tatyana Svitkina
Keyword(s):  
Electron Microscopy ◽  
Actin Cytoskeleton ◽  
Actin Filament ◽  
Dendritic Spines ◽  
Dendritic Spine ◽  
Myosin Ii ◽  
Capping Protein ◽  
Dominant Feature ◽  
Presynaptic Boutons ◽  
Spine Morphogenesis

Excitatory synapses in the brain play key roles in learning and memory. The formation and functions of postsynaptic mushroom-shaped structures, dendritic spines, and possibly of presynaptic terminals, rely on actin cytoskeleton remodeling. However, the cytoskeletal architecture of synapses remains unknown hindering the understanding of synapse morphogenesis. Using platinum replica electron microscopy, we characterized the cytoskeletal organization and molecular composition of dendritic spines, their precursors, dendritic filopodia, and presynaptic boutons. A branched actin filament network containing Arp2/3 complex and capping protein was a dominant feature of spine heads and presynaptic boutons. Surprisingly, the spine necks and bases, as well as dendritic filopodia, also contained a network, rather than a bundle, of branched and linear actin filaments that was immunopositive for Arp2/3 complex, capping protein, and myosin II, but not fascin. Thus, a tight actin filament bundle is not necessary for structural support of elongated filopodia-like protrusions. Dynamically, dendritic filopodia emerged from densities in the dendritic shaft, which by electron microscopy contained branched actin network associated with dendritic microtubules. We propose that dendritic spine morphogenesis begins from an actin patch elongating into a dendritic filopodium, which tip subsequently expands via Arp2/3 complex-dependent nucleation and which length is modulated by myosin II-dependent contractility.

Marginal Iodine Deficiency Affects Dendritic Spine Development by Disturbing the Function of Rac1 Signaling Pathway on Cytoskeleton

2016 ◽  
Vol 54 (1) ◽  
pp. 437-449 ◽  
Author(s):  
Hui Min ◽  
Jing Dong ◽  
Yi Wang ◽  
Yuan Wang ◽  
Ye Yu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Iodine Deficiency ◽  
Dendritic Spine ◽  
Spine Development

Role of actin cytoskeleton in dendritic spine morphogenesis

2007 ◽  
Vol 51 (2-4) ◽  
pp. 92-104 ◽  
Author(s):  
Yuko Sekino ◽  
Nobuhiko Kojima ◽  
Tomoaki Shirao
Keyword(s):  
Actin Cytoskeleton ◽  
Dendritic Spine ◽  
Spine Morphogenesis

scholarly journals Npas4 Regulates Mdm2 and thus Dcx in Experience-Dependent Dendritic Spine Development of Newborn Olfactory Bulb Interneurons

Cell Reports ◽  
2014 ◽  
Vol 8 (3) ◽  
pp. 843-857 ◽  
Author(s):  
Sei-ichi Yoshihara ◽  
Hiroo Takahashi ◽  
Nobushiro Nishimura ◽  
Masahito Kinoshita ◽  
Ryo Asahina ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Dendritic Spine ◽  
Spine Development

Chronic Alcohol Alters Dendritic Spine Development in Neurons in Primary Culture

2013 ◽  
Vol 24 (4) ◽  
pp. 532-548 ◽  
Author(s):  
Ana M. Romero ◽  
Jaime Renau-Piqueras ◽  
M. Pilar Marin ◽  
Joaquin Timoneda ◽  
Maria T. Berciano ◽  
...  
Keyword(s):  
Primary Culture ◽  
Dendritic Spine ◽  
Chronic Alcohol ◽  
Spine Development
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