scholarly journals Hippocampal regulation of aversive memories

2011 ◽  
Vol 21 (3) ◽  
pp. 460-466 ◽  
Author(s):  
Ki Ann Goosens
Keyword(s):  
Hippocampal Regulation

scholarly journals Evidence for hippocampal regulation of neuroendocrine neurons of the hypothalamo-pituitary-adrenocortical axis

1989 ◽  
Vol 9 (9) ◽  
pp. 3072-3082 ◽  
Author(s):  
JP Herman ◽  
MK Schafer ◽  
EA Young ◽  
R Thompson ◽  
J Douglass ◽  
...  
Keyword(s):  
Neuroendocrine Neurons ◽  
Hippocampal Regulation

The ventral hippocampal regulation of prepulse inhibition and its disruption by apomorphine in rats are not mediated via the fornix

Neuroscience ◽  
2004 ◽  
Vol 123 (3) ◽  
pp. 675-685 ◽  
Author(s):  
N.R Swerdlow ◽  
J.M Shoemaker ◽  
H.R Noh ◽  
L Ma ◽  
I Gaudet ◽  
...  
Keyword(s):  
Prepulse Inhibition ◽  
Hippocampal Regulation

Accumbens-caudate-septal circuit as a system for hippocampal regulation: involvement of a GABAergic neurotransmission

1992 ◽  
Vol 22 (1) ◽  
pp. 3-16 ◽  
Author(s):  
M Sabatino ◽  
G Ferraro ◽  
G Caravaglios ◽  
P Sardo ◽  
A Aloisio ◽  
...  
Keyword(s):  
Gabaergic Neurotransmission ◽  
Hippocampal Regulation

scholarly journals Dorsal hippocampal regulation of memory reconsolidation processes that facilitate drug context-induced cocaine-seeking behavior in rats

2009 ◽  
Vol 30 (5) ◽  
pp. 901-912 ◽  
Author(s):  
Donna R. Ramirez ◽  
Guinevere H. Bell ◽  
Heather C. Lasseter ◽  
Xiaou Xie ◽  
Stephanie A. Traina ◽  
...  
Keyword(s):  
Memory Reconsolidation ◽  
Dorsal Hippocampal ◽  
Cocaine Seeking ◽  
Seeking Behavior ◽  
Hippocampal Regulation

scholarly journals Subiculum – BNST Structural Connectivity in Humans and Macaques

2021 ◽  
Author(s):  
Samuel C Berry ◽  
Andrew D Lawrence ◽  
Thomas M Lancaster ◽  
Chiara M Casella ◽  
John P Aggleton ◽  
...  
Keyword(s):  
Structural Connectivity ◽  
Principal Component ◽  
Final Analysis ◽  
Self Report ◽  
Neural Pathways ◽  
Bed Nucleus ◽  
Report Data ◽  
Self Report Data ◽  
Hippocampal Regulation

Invasive tract-tracing studies in rodents implicate a direct connection between the subiculum and bed nucleus of the stria terminalis (BNST) as a key component of neural pathways mediating hippocampal regulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. A clear characterisation of the connections linking the subiculum and BNST in humans and non-human primates is lacking. To address this, we first delineated the projections from the subiculum to the BNST using anterograde tracers injected into macaque monkeys, revealing evidence for a monosynaptic subiculum-BNST projection involving the fornix. Second, we used in vivo diffusion MRI tractography in macaques and humans to demonstrate substantial subiculum complex connectivity to the BNST in both species. This connection was primarily mediated through the fornix, with additional connectivity via the amygdala, consistent with rodent anatomy. Third, utilising the twin-based nature of our human sample, we found that microstructural properties of these tracts are moderately heritable (h2 ~ 0.5). In a final analysis, we found no evidence of any significant association between subiculum complex-BNST tract microstructure and indices of perceived stress/dispositional negativity and alcohol use, derived from principal component analysis decomposition of self-report data. We did, however, find subiculum complex-BNST tract microstructure associations with BMI, age, and sex. Our findings address a key translational gap in our knowledge of the neurocircuitry regulating stress.

scholarly journals Inhibitory hippocampo–septal projection controls locomotion and exploratory behavior

2021 ◽  
Author(s):  
Yuh-Tarng Chen ◽  
Jun Guo ◽  
Wei Xu
Keyword(s):  
Exploratory Behavior ◽  
Spatial Representation ◽  
Representation Learning ◽  
Medial Septum ◽  
Retrosplenial Cortex ◽  
The Other ◽  
Animal Locomotion ◽  
Neuronal Mechanisms ◽  
Locomotion Speed ◽  
Hippocampal Regulation

Although the hippocampus is generally considered a cognitive center for spatial representation, learning and memory, increasing evidence supports its roles in regulation of locomotion. However, the neuronal mechanisms of hippocampal regulation of locomotion and exploratory behavior remain unclear. Here we found that the inhibitory hippocampo-septal projection bi–directionally controls locomotion speed of mice. Pharmacogenetic activation of these septum–projecting interneurons decreased locomotion and exploratory behavior. Similarly, activation of the hippocampus–originated inhibitory terminal in the medial septum reduced locomotion. On the other hand, inhibition of the hippocampus–originated inhibitory terminal increased locomotion. The locomotion-regulative roles were specific to the septal projecting interneurons as activation of hippocampal interneurons projecting to the retrosplenial cortex did not change animal locomotion. Therefore, this study reveals a specific long-range inhibitory output from the hippocampus in the regulation of animal locomotion.

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