Theoretical investigations on copper catalyzed C N cross-coupling reaction between aryl chlorides and amines

2018 ◽  
Vol 1134 ◽  
pp. 1-7 ◽  
Author(s):  
Khalil Ahmad ◽  
Bilal Ahmad Khan ◽  
Bilal Akram ◽  
Jahanzeb Khan ◽  
Rashid Mahmood ◽  
...  
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
Aryl Chlorides ◽  
Cross Coupling Reaction ◽  
Theoretical Investigations

Nickel-catalysed cross-coupling reaction of aryl(trialkyl)silanes with aryl chlorides and tosylates

2011 ◽  
Vol 47 (1) ◽  
pp. 307-309 ◽  
Author(s):  
Shi Tang ◽  
Masahide Takeda ◽  
Yoshiaki Nakao ◽  
Tamejiro Hiyama
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
Aryl Chlorides ◽  
Cross Coupling Reaction

scholarly journals Lewis acid-mediated Suzuki–Miyaura cross-coupling reaction

2021 ◽  
Vol 4 (12) ◽  
pp. 1080-1088
Author(s):  
Takashi Niwa ◽  
Yuta Uetake ◽  
Motoyuki Isoda ◽  
Tadashi Takimoto ◽  
Miki Nakaoka ◽  
...  
Keyword(s):  
Controlled Release ◽  
Lewis Acid ◽  
Reliable Method ◽  
Bond Formation ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Carbon Carbon Bond ◽  
Cross Coupling Reaction ◽  
Theoretical Investigations ◽  
Active Intermediate

AbstractThe palladium-catalysed Suzuki–Miyaura cross-coupling reaction of organohalides and organoborons is a reliable method for carbon–carbon bond formation. This reaction involves a base-mediated transmetalation process, but the presence of a base also promotes competitive protodeborylation. Herein, we established a Suzuki–Miyaura cross-coupling reaction via Lewis acid-mediated transmetalation of an organopalladium(II) intermediate with organoborons. Experimental and theoretical investigations indicate that the controlled release of the transmetalation-active intermediate enables base-independent transmetalation under heating conditions and enhances the applicable scope of this process. This system enables us to avoid the addition of a traditional base and, thus, renders substrates with base-sensitive moieties available. Results from this research further expand the overall utility of cross-coupling chemistry.

Suzuki-Miyaura Cross-Coupling Towards 4-Amino Biphenyl Intermediates

2019 ◽  
Author(s):  
Tomasz Jastrząbek ◽  
Artur Ulikowski ◽  
Rafał Lisiak
Keyword(s):  
Chemical Industry ◽  
Short Communication ◽  
Phenylboronic Acid ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Amino Groups ◽  
Aryl Chlorides ◽  
Cross Coupling Reaction ◽  
Direct Cross

The preparation of biphenyl derivatives bearing amino groups via direct cross-coupling reaction is being widely explored due to its importance for many branches of the chemical industry. One of the necessary components for such a transformation are halogenated arenes. In order to make the process more economical, we focus on inexpensive and easily available aryl chlorides which usually are not considered reagents of choice for catalytic couplings. In the following short communication, we report the results of the coupling of relatively unreactive chloroaniline with a fluorinated phenylboronic acid leading to the corresponding aminobiphenyl.<br>

Room temperature Stille cross-coupling reaction of unreactive aryl chlorides and heteroaryl chlorides

2010 ◽  
Vol 46 (3) ◽  
pp. 478-480 ◽  
Author(s):  
Dong-Hwan Lee ◽  
Abu Taher ◽  
Wha-Seung Ahn ◽  
Myung-Jong Jin
Keyword(s):  
Room Temperature ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Aryl Chlorides ◽  
Cross Coupling Reaction
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