Porous bone tissue scaffold concept based on shape memory PLA/Fe3O4

2020 ◽  
pp. 108563
Author(s):  
Wei Zhao ◽  
Zhipeng Huang ◽  
Liwu Liu ◽  
Wenbo Wang ◽  
Jinsong Leng ◽  
...  
Keyword(s):  
Shape Memory ◽  
Bone Tissue ◽  
Tissue Scaffold

Biocompatibility and biodegradation studies of PCL/β-TCP bone tissue scaffold fabricated by structural porogen method

2012 ◽  
Vol 23 (9) ◽  
pp. 2217-2226 ◽  
Author(s):  
Lin Lu ◽  
Qingwei Zhang ◽  
David Wootton ◽  
Richard Chiou ◽  
Dichen Li ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Scaffold

scholarly journals The Osteogenesis of Bone Marrow Stem Cells on mPEG-PCL-mPEG/Hydroxyapatite Composite Scaffold via Solid Freeform Fabrication

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Han-Tsung Liao ◽  
Yo-Yu Chen ◽  
Yu-Ting Lai ◽  
Ming-Fa Hsieh ◽  
Cho-Pei Jiang
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Bone Tissue ◽  
Composite Scaffold ◽  
Solid Freeform Fabrication ◽  
Bone Marrow Stem Cells ◽  
High Porosity ◽  
Tissue Scaffold

The study described a novel bone tissue scaffold fabricated by computer-aided, air pressure-aided deposition system to control the macro- and microstructure precisely. The porcine bone marrow stem cells (PBMSCs) seeded on either mPEG-PCL-mPEG (PCL) or mPEG-PCL-mPEG/hydroxyapatite (PCL/HA) composite scaffold were cultured under osteogenic medium to test the ability of osteogenesisin vitro. The experimental outcomes indicated that both scaffolds possessed adequate pore size, porosity, and hydrophilicity for the attachment and proliferation of PBMSCs and the PBMSCs expressed upregulated genes of osteogensis and angiogenesis in similar manner on both scaffolds. The major differences between these two types of the scaffolds were the addition of HA leading to higher hardness of PCL/HA scaffold, cell proliferation, and VEGF gene expression in PCL/HA scaffold. However, thein vivobone forming efficacy between PBMSCs seeded PCL and PCL/HA scaffold was different from thein vitroresults. The outcome indicated that the PCL/HA scaffold which had bone-mimetic environment due to the addition of HA resulted in better bone regeneration and mechanical strength than those of PCL scaffold. Therefore, providing a bone-mimetic scaffold is another crucial factor for bone tissue engineering in addition to the biocompatibility, 3D architecture with high porosity, and interpored connection.

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