scholarly journals Pre-treatment peripheral biomarkers associated with treatment response in panic symptoms in patients with major depressive disorder and panic disorder: A 12-week follow-up study

2019 ◽  
Vol 95 ◽  
pp. 152140 ◽  
Author(s):  
Kiwon Kim ◽  
Eun Hye Jang ◽  
Ah Young Kim ◽  
Maurizio Fava ◽  
David Mischoulon ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Panic Disorder ◽  
Depressive Disorder ◽  
Treatment Response ◽  
Major Depressive ◽  
Follow Up Study ◽  
Panic Symptoms ◽  
Pre Treatment

scholarly journals Intrinsic connectomes are a predictive biomarker of remission in major depressive disorder

2019 ◽  
Vol 25 (7) ◽  
pp. 1537-1549 ◽  
Author(s):  
Mayuresh S. Korgaonkar ◽  
Andrea N. Goldstein-Piekarski ◽  
Alexander Fornito ◽  
Leanne M. Williams
Keyword(s):  
Major Depressive Disorder ◽  
Functional Connectivity ◽  
Depressive Disorder ◽  
Treatment Response ◽  
Antidepressant Treatment ◽  
Predictive Biomarker ◽  
Major Depressive ◽  
Attention Networks ◽  
Pre Treatment

Abstract Although major depressive disorder (MDD) is associated with altered functional coupling between disparate neural networks, the degree to which such measures are ameliorated by antidepressant treatment is unclear. It is also unclear whether functional connectivity can be used as a predictive biomarker of treatment response. Here, we used whole-brain functional connectivity analysis to identify neural signatures of remission following antidepressant treatment, and to identify connectomic predictors of treatment response. 163 MDD and 62 healthy individuals underwent functional MRI during pre-treatment baseline and 8-week follow-up sessions. Patients were randomized to escitalopram, sertraline or venlafaxine-XR antidepressants and assessed at follow-up for remission. Baseline measures of intrinsic functional connectivity between each pair of 333 regions were analyzed to identify pre-treatment connectomic features that distinguish remitters from non-remitters. We then interrogated these connectomic differences to determine if they changed post-treatment, distinguished patients from controls, and were modulated by medication type. Irrespective of medication type, remitters were distinguished from non-remitters by greater connectivity within the default mode network (DMN); specifically, between the DMN, fronto-parietal and somatomotor networks, the DMN and visual, limbic, auditory and ventral attention networks, and between the fronto-parietal and somatomotor networks with cingulo-opercular and dorsal attention networks. This baseline hypo-connectivity for non-remitters also distinguished them from controls and increased following treatment. In contrast, connectivity for remitters was higher than controls at baseline and also following remission, suggesting a trait-like connectomic characteristic. Increased functional connectivity within and between large-scale intrinsic brain networks may characterize acute recovery with antidepressants in depression.

Evaluation of psychosocial functioning in the acute treatment term of major depressive disorder: a 16-week multi-centered follow-up study

2021 ◽  
pp. 102883
Author(s):  
Neslihan ALTUNSOY ◽  
Didem SÜCÜLLÜOĞLU DİKİCİ ◽  
Fikret Poyraz ÇÖKMÜŞ ◽  
Hüseyin Murat ÖZKAN ◽  
Kadir AŞÇIBAŞI ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Psychosocial Functioning ◽  
Acute Treatment ◽  
Major Depressive ◽  
Follow Up Study

Increased mitogen-stimulated lymphocyte proliferation is associated with the clinical response in major depressive disorder in women: A follow-up study

2016 ◽  
Vol 239 ◽  
pp. 220-221
Author(s):  
Antti-Pekka Elomaa ◽  
Heimo Viinamäki ◽  
Ilkka T. Harvima ◽  
Heli Koivumaa-Honkanen ◽  
Kirsi Honkalampi ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Clinical Response ◽  
Lymphocyte Proliferation ◽  
Major Depressive ◽  
Follow Up Study
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