Relationship of clinical course of illness variables to medical comorbidities in 900 adult outpatients with bipolar disorder

2015 ◽  
Vol 56 ◽  
pp. 21-28 ◽  
Author(s):  
Robert M. Post ◽  
Lori Altshuler ◽  
Gabriele S. Leverich ◽  
Mark A. Frye ◽  
Trish Suppes ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Clinical Course ◽  
Course Of Illness ◽  
Medical Comorbidities ◽  
Relationship Of ◽  
Illness Variables

COVID-19 in children: Pathogenesis and current status

2020 ◽  
Author(s):  
Lawrence Frenkel ◽  
Fernando Gomez ◽  
Joseph A Bellanti
Keyword(s):  
Respiratory Disease ◽  
Respiratory Symptoms ◽  
Distress Syndrome ◽  
Clinical Course ◽  
Current Status ◽  
Current Evidence ◽  
Initial Description ◽  
Relationship Of ◽  
Inflammatory Syndrome ◽  
The Relationship

Background: Since its initial description in December 2019 in Wuhan, China, coronavirus disease 2019 (COVID-19) has rapidly progressed into a worldwide pandemic, which has affected millions of lives. Unlike the disease in adults, the vast majority of children with COVID-19 have mild symptoms and are largely spared from severe respiratory disease. However, thereare children who have significant respiratory disease, and some may develop a hyperinflammatory response similar to thatseen in adults with COVID-19 and in children with Kawasaki disease (KD), which has been termed multisystem inflammatory syndrome in children (MIS-C).Objective: The purpose of this report was to examine the current evidence that supports the etiopathogenesis of COVID-19 in children and the relationship of COVID-19 with KD and MIS-C as a basis for a better understanding of the clinical course, diagnosis, and management of these clinically perplexing conditions.Results: The pathogenesis of COVID-19 is carried out in two distinct but overlapping phases of COVID-19: the first triggered by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) itself and the second by the host immune response. Children with KD have fewer of the previously described COVID-19–associated KD features with less prominent acute respiratory distress syndrome and shock than children with MIS-C.Conclusion: COVID-19 in adults usually includes severe respiratory symptoms and pathology, with a high mortality. Ithas become apparent that children are infected as easily as adults but are more often asymptomatic and have milder diseasebecause of their immature immune systems. Although children are largely spared from severe respiratory disease, they canpresent with a SARS-CoV-2–associated MIS-C similar to KD.

Varicella and Cortisone

PEDIATRICS ◽  
1956 ◽  
Vol 18 (1) ◽  
pp. 160-162 ◽  
Author(s):  
ROBERT J. HAGGERTY ◽  
R. CANNON ELEY
Keyword(s):  
Infectious Diseases ◽  
Clinical Course ◽  
Medical Center ◽  
Post Mortem ◽  
The Past ◽  
Vesicle Fluid ◽  
Heart Blood ◽  
Cortisone Therapy ◽  
Relationship Of

In the past 2 years we have seen 2 patients at the Children's Medical Center, who, while receiving cortisone therapy, developed varicella and died following a state of shock within a few days after the appearance of the vesicles. Post-mortem examinations of these patients revealed hemorrhagic vesicles throughout all viscera. In 1 case the virus of varicella was grown from vesicle fluid, heart blood, and lung. Since fatalities from varicella in childhood are so rarely encountered, even by physicians with vast experience in the field of infectious diseases, and since the clinical course of the infection in these two patients was so fulminating, the possible relationship of cortisone administration was raised.

Schizophrenia, Bipolar Disorder and Depression a Discriminant Analysis, using ‘Lifetime’ Psychopathology Ratings

1991 ◽  
Vol 159 (4) ◽  
pp. 485-494 ◽  
Author(s):  
I. F. Brockington ◽  
A. Roper ◽  
J. Copas ◽  
M. Buckley ◽  
C. E. Andrade ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Discriminant Analysis ◽  
Canonical Variate ◽  
Course Of Illness ◽  
Distinct Grouping

Discriminant and canonical variate analyses were performed using 302 patients, on whom ratings of lifetime psychopathology and course of illness had been made. DSM–III diagnoses were used to form the criterion groups. Bipolar disorder emerged as a distinct grouping, but there are reasons for dissatisfaction with its definition. The remaining patients formed a ‘schizodepressive continuum’, but this also had a tendency to bimodality. It is possible that the distinction between schizophrenia and depression was obscured by inadequacies in the data and the inclusion of excessive numbers of patients with schizoaffective depression in this study.

The Relationship Between Smoking and Suicidal Behavior, Comorbidity, and Course of Illness in Bipolar Disorder

2006 ◽  
Vol 67 (12) ◽  
pp. 1907-1911 ◽  
Author(s):  
Michael J. Ostacher ◽  
Andrew A. Nierenberg ◽  
Roy H. Perlis ◽  
Polina Eidelman ◽  
David J. Borrelli ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Suicidal Behavior ◽  
Course Of Illness ◽  
The Relationship

scholarly journals Hospitalized Adult Patients with 2009 Pandemic Influenza A (H1N1) in Kaunas, Lithuania

Medicina ◽  
2011 ◽  
Vol 47 (1) ◽  
pp. 11-18 ◽  
Author(s):  
◽  
◽  
◽  
◽  
◽  
...  
Keyword(s):  
Risk Factors ◽  
Symptom Onset ◽  
Pandemic Influenza ◽  
Influenza A ◽  
H1n1 Virus ◽  
Clinical Course ◽  
Antiviral Treatment ◽  
Course Of Illness ◽  
Influenza A H1n1 ◽  
Complicated Course

The objective of this study was to identify case characteristics and clinical course of the disease in patients hospitalized with 2009 pandemic influenza A (H1N1) infection during the first wave of the pandemic and to identify risk factors associated with the complicated course of illness. Material and methods. A retrospective study of adult cases of the laboratory-confirmed 2009 pandemic influenza A (H1N1) virus admitted to three hospitals in Kaunas between November 1, 2009, and March 15, 2010, was carried out. The main outcome measures were clinical characteristics, risk factors for complicated disease, treatment, and clinical course of the disease. Results. The study enrolled 121 of the 125 patients hospitalized due to 2009 pandemic influenza A (H1N1) virus infection. The median age was 31 years (range, 18–83); 5% of the patients were aged more than 65 years. Pregnant and postpartum women comprised 26% of all hospitalized cases. Nearly half (49.5%) of those who underwent chest radiography had findings consistent with pneumonia, which was bilateral in one-third of cases. The risk to have pandemic influenza complicated by pneumonia increased significantly with one-day delay from symptom onset to antiviral treatment (OR, 2.241; 95% CI, 1.354–3.710). More than half (57%) of the patients received antiviral treatment. In 45% of the treated patients, antiviral drugs were administered within 48 hours from symptom onset. Intensive care was required in 7.4% of the cases. The overall mortality was 5% (6/121). The median age of the patients who died was 43.5 years (range, 23–62); 4 patients had been previously healthy, 1 patient suffered from chronic lympholeukemia, and 1 patient was a pregnant woman. Conclusion. The 2009 pandemic influenza A (H1N1) caused considerable morbidity in a significant proportion of hospitalized adults. The main risk factor associated with the complicated course of illness was delayed antiviral treatment.

scholarly journals Abnormal Functional Relationship of Sensorimotor Network With Neurotransmitter-Related Nuclei via Subcortical-Cortical Loops in Manic and Depressive Phases of Bipolar Disorder

2019 ◽  
Vol 46 (1) ◽  
pp. 163-174 ◽  
Author(s):  
Matteo Martino ◽  
Paola Magioncalda ◽  
Benedetta Conio ◽  
Laura Capobianco ◽  
Daniel Russo ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Functional Relationship ◽  
A Priori ◽  
Subcortical Structures ◽  
Sensorimotor Network ◽  
Functional Relationships ◽  
Fmri Study ◽  
Zero Values ◽  
Psychomotor Symptoms ◽  
Relationship Of

Abstract Objective Manic and depressive phases of bipolar disorder (BD) show opposite psychomotor symptoms. Neuronally, these may depend on altered relationships between sensorimotor network (SMN) and subcortical structures. The study aimed to investigate the functional relationships of SMN with substantia nigra (SN) and raphe nuclei (RN) via subcortical-cortical loops, and their alteration in bipolar mania and depression, as characterized by psychomotor excitation and inhibition. Method In this resting-state functional magnetic resonance imaging (fMRI) study on healthy (n = 67) and BD patients (n = 100), (1) functional connectivity (FC) between thalamus and SMN was calculated and correlated with FC from SN or RN to basal ganglia (BG)/thalamus in healthy; (2) using an a-priori-driven approach, thalamus-SMN FC, SN-BG/thalamus FC, and RN-BG/thalamus FC were compared between healthy and BD, focusing on manic (n = 34) and inhibited depressed (n = 21) patients. Results (1) In healthy, the thalamus-SMN FC showed a quadratic correlation with SN-BG/thalamus FC and a linear negative correlation with RN-BG/thalamus FC. Accordingly, the SN-related FC appears to enable the thalamus-SMN coupling, while the RN-related FC affects it favoring anti-correlation. (2) In BD, mania showed an increase in thalamus-SMN FC toward positive values (ie, thalamus-SMN abnormal coupling) paralleled by reduction of RN-BG/thalamus FC. By contrast, inhibited depression showed a decrease in thalamus-SMN FC toward around-zero values (ie, thalamus-SMN disconnection) paralleled by reduction of SN-BG/thalamus FC (and RN-BG/thalamus FC). The results were replicated in independent HC and BD datasets. Conclusions These findings suggest an abnormal relationship of SMN with neurotransmitters-related areas via subcortical-cortical loops in mania and inhibited depression, finally resulting in psychomotor alterations.

Patterns of Symptom Distress in Adults Receiving Treatment for Lung Cancer

2002 ◽  
Vol 18 (3) ◽  
pp. 150-159 ◽  
Author(s):  
Mary E. Cooley ◽  
Thomas H. Short ◽  
Helene J. Moriarty
Keyword(s):  
Lung Cancer ◽  
Secondary Analysis ◽  
Symptom Distress ◽  
Course Of Illness ◽  
Lung Cancer Patients ◽  
Treatment Groups ◽  
Relationship Of ◽  
The Relationship ◽  
Over Time

Knowledge of the patterns of symptom distress in adults receiving treatment for lung cancer is an important first step in developing interventions that can potentially lessen symptom distress. The purposes of this secondary analysis were to describe the changes in patterns of symptom distress over time in adults receiving treatment for lung cancer, and to examine the relationship of selected demographic and clinical characteristics to symptom distress. Complete data were available for 117 patients. The patterns of symptom distress in adults receiving treatment for lung cancer varied between treatment groups and over time. Symptom distress scores were moderate to high on entry into the study, indicating that symptom management in newly diagnosed lung cancer patients is essential and should begin early in the course of illness. Moreover, clinical interventions should be tailored to the type of treatment. Various demographic and clinical variables were weak and inconsistent predictors of symptom distress, underscoring the importance of examining the role of psychosocial factors in mediating symptom distress.

Sex differences in bipolar disorder: Impact of lifetime cannabis use on clinical course, functioning, and quality of life in bipolar disorder

2020 ◽  
Vol 266 ◽  
pp. 258-262 ◽  
Author(s):  
Lorena de la Fuente-Tomás ◽  
Belén Arranz ◽  
Angela Velasco ◽  
Pilar Sierra ◽  
Mónica Sanchez-Autet ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Bipolar Disorder ◽  
Sex Differences ◽  
Clinical Course ◽  
Cannabis Use
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