One year follow-up of alcohol and illicit substance use in first-episode psychosis: Does gender matter?

2014 ◽  
Vol 55 (2) ◽  
pp. 274-282 ◽  
Author(s):  
Elisabeth Heffermehl Lange ◽  
Ragnar Nesvåg ◽  
Petter Andreas Ringen ◽  
Cecilie Bhandari Hartberg ◽  
Unn Kristin Haukvik ◽  
...  
Keyword(s):  
Substance Use ◽  
First Episode Psychosis ◽  
First Episode ◽  
Illicit Substance ◽  
Illicit Substance Use ◽  
Episode Psychosis ◽  
One Year

scholarly journals Gender differences in clinical presentation and illicit substance use during first episode psychosis: a natural language processing, electronic case register study

BMJ Open ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. e042949
Author(s):  
Jessica Irving ◽  
Craig Colling ◽  
Hitesh Shetty ◽  
Megan Pritchard ◽  
Robert Stewart ◽  
...  
Keyword(s):  
Gender Differences ◽  
Substance Use ◽  
Language Processing ◽  
Negative Symptoms ◽  
Clinical Presentation ◽  
First Episode Psychosis ◽  
First Episode ◽  
Illicit Substance ◽  
Illicit Substance Use ◽  
Episode Psychosis

ObjectiveTo determine whether gender differences in symptom presentation at first episode psychosis (FEP) remain even when controlling for substance use, age and ethnicity, using natural language processing applied to electronic health records (EHRs).Design, setting and participantsData were extracted from EHRs of 3350 people (62% male patients) who had presented to the South London and Maudsley NHS Trust with a FEP between 1 April 2007 and 31 March 2017. Logistic regression was used to examine gender differences in the presentation of positive, negative, depressive, mania and disorganisation symptoms.Exposure(s) (for observational studies)Gender (male vs female).Main outcome(s) and measure(s)Presence of positive, negative, depressive, mania and disorganisation symptoms at initial clinical presentation.ResultsEight symptoms were significantly more prevalent in men (poverty of thought, negative symptoms, social withdrawal, poverty of speech, aggression, grandiosity, paranoia and agitation). Conversely, tearfulness, low energy, reduced appetite, low mood, pressured speech, mood instability, flight of ideas, guilt, mutism, insomnia, poor concentration, tangentiality and elation were more prevalent in women than men. Negative symptoms were more common among men (OR 1.85, 95% CI 1.33 to 2.62) and depressive and manic symptoms more common among women (OR 0.30, 95% CI 0.26 to 0.35). After adjustment for illicit substance use, the strength of associations between gender and negative, manic and depression symptoms increased, whereas gender differences in aggression, agitation, paranoia and grandiosity became insignificant.ConclusionsThere are clear gender differences in the clinical presentation of FEP. Our findings suggest that gender can have a substantial influence on the nature of clinical presentation in people with psychosis, and that this is only partly explained by exposure to illicit substance use.

Illicit substance use and its correlates in first episode psychosis

2010 ◽  
Vol 121 (5) ◽  
pp. 351-358 ◽  
Author(s):  
R. Mazzoncini ◽  
K. Donoghue ◽  
J. Hart ◽  
C. Morgan ◽  
G. A. Doody ◽  
...  
Keyword(s):  
Substance Use ◽  
First Episode Psychosis ◽  
First Episode ◽  
Illicit Substance ◽  
Illicit Substance Use ◽  
Episode Psychosis

Specialized assertive community treatment intervention for homeless youth with first episode psychosis and substance use disorder: A 2‐year follow‐up study

2019 ◽  
Vol 14 (2) ◽  
pp. 203-210 ◽  
Author(s):  
Virginie Doré‐Gauthier ◽  
Jean‐Philippe Miron ◽  
Dider Jutras‐Aswad ◽  
Clairélaine Ouellet‐Plamondon ◽  
Amal Abdel‐Baki
Keyword(s):  
Substance Use ◽  
Substance Use Disorder ◽  
Homeless Youth ◽  
First Episode Psychosis ◽  
Community Treatment ◽  
First Episode ◽  
Treatment Intervention ◽  
Follow Up Study ◽  
Episode Psychosis

scholarly journals S132. SAMPLING BIAS IN STUDIES OF FIRST-EPISODE PSYCHOSIS – A FOLLOW-UP STUDY

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S85-S86
Author(s):  
Maija Walta ◽  
Heikki Laurikainen ◽  
Reetta-Liina Armio ◽  
Tiina From ◽  
Raimo K R Salokangas ◽  
...  
Keyword(s):  
Clinical Care ◽  
Real Life ◽  
Sampling Bias ◽  
First Episode Psychosis ◽  
Dropping Out ◽  
First Episode ◽  
Episode Psychosis ◽  
Involuntary Care ◽  
One Year

Abstract Background Attrition rates and sampling bias in controlled clinical studies are a concern when evaluating the relevance of the results to a specific patient population in a real-life clinical / treatment setting. Dropout rates in studies on psychotic disorders are high and many eligibility criteria may lead to bias in study samples. We wanted to analyze how representative are the patient samples typically included in first-episode psychosis studies such as the Turku Early Psychosis (TEPS) study by using a platform of 3772 consecutive admissions to clinical psychiatric services of Turku Psychiatry. Methods TEPS study was started in 2011 as a part of a larger study on psychosis treatment processes in Turku Psychiatric services. Each patient, inpatient and outpatient, went through initial clinical screening by the treatment group which was followed by a structured evaluation if the screen for first-episode psychosis was positive. Between Oct 2011 and June 2016 there were 195 patients with first-episode psychosis (FEP) suitable to the TEPS study. Of them 102 were willing and 93 were not willing to participate or were not reached in a baseline structured evaluation. Using patient records, we compared if these two groups differed in terms of clinical variables, treatment or prognosis during a 1-year follow-up. Time of hospital stay, involuntary vs. voluntary admission, coercive measures during the hospital care, re-hospitalizations and drop-out from the clinical care during the follow-up were used as outcomes. Results Non-participating (NTP) group had higher rate of involuntary care than participating (TP) group (70 % vs 62 %) as well as higher rate of coercion during the treatment and higher rate of re-admissions during the follow-up than the TP group (36 % vs 22 % and 41 % vs 34 %, respectively) but these differences did not reach statistical significance. During the one-year follow-up NTP group had a significantly higher rate of dropping out from the clinical care than participating TP group (48 % vs 30 %, p=0.01). NTP group had also higher rate of dropping out of clinical treatment mainly because of patient non-adherence (33 % vs 16 %, p=0.03). Discussion Nearly half (47 %) of the intent-to-study FEP patients were not reached or declined to participate in our study. Non-participating patients had a slightly more severe illness and poorer treatment adherence during one-year follow-up. The clinical differences were not as marked as we expected. E.g. involuntary care, inpatient care and more coercion during the follow-up were not significantly different between NTP and TP groups. Nevertheless, the data suggest considerable differences between participating and non-participating patients with first-episode psychosis which should be taken in to account when evaluating the generalizability of the results for an unselected group of psychotic patients in ‘real-life’ clinical care.

Volumetric and morphological characteristics of the hippocampus are associated with progression to schizophrenia in patients with first-episode psychosis

2017 ◽  
Vol 45 ◽  
pp. 1-5 ◽  
Author(s):  
R. Sauras ◽  
A. Keymer ◽  
A. Alonso-Solis ◽  
A. Díaz ◽  
C. Molins ◽  
...  
Keyword(s):  
Morphological Changes ◽  
Morphological Characteristics ◽  
First Episode Psychosis ◽  
First Episode ◽  
Control Group ◽  
Subcortical Structures ◽  
Episode Psychosis ◽  
Left Hippocampus ◽  
One Year

AbstractBackground:Abnormalities in the hippocampus have been implicated in the pathophysiology of psychosis. However, it is still unclear whether certain abnormalities are a pre-existing vulnerability factor, a sign of disease progression or a consequence of environmental factors. We hypothesized that first-episode psychosis patients who progress to schizophrenia after one year of follow up will display greater volumetric and morphological changes from the very beginning of the disorder.Methods:We studied the hippocampus of 41 patients with a first-episode psychosis and 41 matched healthy controls. MRI was performed at the time of the inclusion in the study. After one year, the whole sample was reevaluated and divided in two groups depending on the diagnoses (schizophrenia vs. non-schizophrenia).Results:Patients who progressed to schizophrenia showed a significantly smaller left hippocampus volume than control group and no-schizophrenia group (F = 3.54; df = 2, 77; P = 0.03). We also found significant differences in the morphology of the anterior hippocampus (CA1) of patients with first-episode psychosis who developed schizophrenia compared with patients who did not.Conclusions:These results are consistent with the assumption of hyperfunctioning dopaminergic cortico-subcortical circuits in schizophrenia, which might be related with an alteration of subcortical structures, such as the hippocampus, along the course of the disease. According with these results, hippocampus abnormalities may serve as a prognostic marker of clinical outcome in patients with a first-episode psychosis.

Diagnostic Stability and Clinical Characteristics in First-episode Psychosis

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
D. Berge ◽  
A. Mane ◽  
P. Salgado ◽  
O. Vilarroya ◽  
A. Merino ◽  
...  
Keyword(s):  
First Episode Psychosis ◽  
First Episode ◽  
Schizophreniform Disorder ◽  
Schizophrenia Spectrum Disorders ◽  
Diagnostic Stability ◽  
Episode Psychosis ◽  
Hospitalization Period ◽  
Wide Variability ◽  
One Year

Introduction:Diagnostic stability in first-episode psychosis shows a wide variability between studies. Amini and cols reported a 50% rate of patients schizophreniform disorder shifting to schizophrenia during the first 12 months period. We report the preliminary follow-up results of our recently ongoing first- episode psychosis unit.Methods:Forty-six patients admitted for a first-episode psichosis to our Inpatient Psychiatric Unit from January 2006 to January 2008 were recruited. Clinical and socio-demographic characteristics were registered during admission period and during the follow-up period.Results:At admission 52% of the first-episode subjects had a diagnosis of psychosis NOS and 32% a schizophreniform disorder diagnosis. after discharge, most of the patients (72%) had a diagnosis of schizophreniform disorder, 16% psychosis NOS and 8% brief psychotic disorder. Six months later, half of the followed-up patients had a schizophreniform disorder diagnosis, and 23% had a diagnosis of schizophrenia. 30% of the patients were drop-outs, mainly referred to other out-patient services. Patients shifting to schizophrenia were younger, predominantly male (75% vs 50% in non-schizophrenia shift), had a lower proportion of university studies and presented a longer hospitalization period at admission. No differences in familial history of psychosis and cannabis use were found. after one-year follow-up period, 50% preserved a schizophreniform disorder diagnosis and 30% were diagnosed as schizophrenia.Conclusions:Schizophrenia spectrum disorders have a high stability in first-episode psychosis during first year follow-up. as in previous studies, male gender is one of the factors that best predicts the shift to schizophrenia.

One-year follow-up study of first suicide attempts in first episode psychosis: Personality traits and temporal pattern

2016 ◽  
Vol 71 ◽  
pp. 121-129 ◽  
Author(s):  
Manuel Canal-Rivero ◽  
Maria Luisa Barrigón ◽  
Salvador Perona-Garcelán ◽  
Juan F. Rodriguez-Testal ◽  
Lucas Giner ◽  
...  
Keyword(s):  
Personality Traits ◽  
Temporal Pattern ◽  
Suicide Attempts ◽  
First Episode Psychosis ◽  
First Episode ◽  
Follow Up Study ◽  
Episode Psychosis ◽  
One Year
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