Elevated specific peripheral cytokines found in major depressive disorder patients with childhood trauma exposure: A cytokine antibody array analysis

2013 ◽  
Vol 54 (7) ◽  
pp. 953-961 ◽  
Author(s):  
Shaojia Lu ◽  
Hongjun Peng ◽  
Lifeng Wang ◽  
Seewoobudul Vasish ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Childhood Trauma ◽  
Trauma Exposure ◽  
Antibody Array ◽  
Array Analysis ◽  
Major Depressive ◽  
Cytokine Antibody Array

scholarly journals Prospective longitudinal voxel-based morphometry study of major depressive disorder in young individuals at high familial risk

2016 ◽  
Vol 46 (11) ◽  
pp. 2351-2361 ◽  
Author(s):  
T. Nickson ◽  
S. W. Y. Chan ◽  
M. Papmeyer ◽  
L. Romaniuk ◽  
A. Macdonald ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
High Risk ◽  
Depressive Disorder ◽  
Mood Disorder ◽  
Childhood Trauma ◽  
Familial Risk ◽  
Voxel Based Morphometry ◽  
Major Depressive ◽  
Potential Biomarker ◽  
Prospective Longitudinal

BackgroundPrevious neuroimaging studies indicate abnormalities in cortico-limbic circuitry in mood disorder. Here we employ prospective longitudinal voxel-based morphometry to examine the trajectory of these abnormalities during early stages of illness development.MethodUnaffected individuals (16–25 years) at high and low familial risk of mood disorder underwent structural brain imaging on two occasions 2 years apart. Further clinical assessment was conducted 2 years after the second scan (time 3). Clinical outcome data at time 3 was used to categorize individuals: (i) healthy controls (‘low risk’, n = 48); (ii) high-risk individuals who remained well (HR well, n = 53); and (iii) high-risk individuals who developed a major depressive disorder (HR MDD, n = 30). Groups were compared using longitudinal voxel-based morphometry. We also examined whether progress to illness was associated with changes in other potential risk markers (personality traits, symptoms scores and baseline measures of childhood trauma), and whether any changes in brain structure could be indexed using these measures.ResultsSignificant decreases in right amygdala grey matter were found in HR MDD v. controls (p = 0.001) and v. HR well (p = 0.005). This structural change was not related to measures of childhood trauma, symptom severity or measures of sub-diagnostic anxiety, neuroticism or extraversion, although cross-sectionally these measures significantly differentiated the groups at baseline.ConclusionsThese longitudinal findings implicate structural amygdala changes in the neurobiology of mood disorder. They also provide a potential biomarker for risk stratification capturing additional information beyond clinically ascertained measures.

Evaluation of Lifetime Trauma Exposure and Physical Health in Women With Posttraumatic Stress Disorder or Major Depressive Disorder

2009 ◽  
Vol 15 (5) ◽  
pp. 618-627 ◽  
Author(s):  
Michelle F. Dennis ◽  
Amanda M. Flood ◽  
Victoria Reynolds ◽  
Gustavo Araujo ◽  
Carolina P. Clancy ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Physical Health ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Trauma Exposure ◽  
Major Depressive ◽  
Lifetime Trauma

White matter integrity in major depressive disorder: Implications of childhood trauma, 5-HTTLPR and BDNF polymorphisms

2016 ◽  
Vol 253 ◽  
pp. 15-25 ◽  
Author(s):  
Erica L. Tatham ◽  
Rajamannar Ramasubbu ◽  
Ismael Gaxiola-Valdez ◽  
Filomeno Cortese ◽  
Darren Clark ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
White Matter ◽  
Depressive Disorder ◽  
Childhood Trauma ◽  
White Matter Integrity ◽  
Major Depressive

scholarly journals Amplitude of Low-Frequency Oscillations in Major Depressive Disorder With Childhood Trauma

2021 ◽  
Vol 11 ◽  
Author(s):  
Zhuoying Wu ◽  
Qianyi Luo ◽  
Huawang Wu ◽  
Zhiyao Wu ◽  
Yingjun Zheng ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Childhood Trauma ◽  
Low Frequency ◽  
Anterior Cingulate ◽  
Dorsal Anterior Cingulate Cortex ◽  
Major Depressive ◽  
Significant Group ◽  
Group Frequency ◽  
Left Insula

Major Depressive Disorder (MDD) with childhood trauma is one of the functional subtypes of depression. Frequency-dependent changes in the amplitude of low-frequency fluctuations (ALFF) have been reported in MDD patients. However, there are few studies on ALFF about MDD with childhood trauma. Resting-state functional magnetic resonance imaging was used to measure the ALFF in 69 MDD patients with childhood trauma (28.7 ± 9.6 years) and 30 healthy subjects (28.12 ± 4.41 years). Two frequency bands (slow-5: 0.010–0.027 Hz; slow-4: 0.027–0.073 Hz) were analyzed. Compared with controls, the MDD with childhood trauma had decreased ALFF in left S1 (Primary somatosensory cortex), and increased ALFF in left insula. More importantly, significant group × frequency interactions were found in right dorsal anterior cingulate cortex (dACC). Our finding may provide insights into the pathophysiology of MDD with childhood trauma.

scholarly journals Neuroendocrine and Inflammatory Effects of Childhood Trauma Following Psychosocial and Inflammatory Stress in Women with Remitted Major Depressive Disorder

2019 ◽  
Vol 9 (12) ◽  
pp. 375
Author(s):  
Laura L.M. Cassiers ◽  
Peter Niemegeers ◽  
Erik Fransen ◽  
Manuel Morrens ◽  
Peter De Boer ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Childhood Trauma ◽  
Psychosocial Stress ◽  
Inflammatory Responses ◽  
Stress Test ◽  
Trier Social Stress Test ◽  
Major Depressive ◽  
Inflammatory Stress ◽  
Tnf Α

The dysregulation of the inflammatory and neuroendocrine systems seen in major depressive disorder (MDD) may persist after remission and this is associated with a higher risk of relapse. This vulnerable subgroup may be characterized by a history of childhood trauma. In a single-blind randomized placebo-controlled crossover study, 21 women with remitted recurrent MDD and 18 healthy controls were exposed to psychosocial stress (Trier social stress test) or inflammatory stress (typhoid vaccine), or both, to investigate the effects of childhood trauma on the neuroendocrine and inflammatory responses. Childhood trauma was assessed using the Childhood Trauma Questionnaire and participants were dichotomized into a traumatized and non-traumatized group. Serum adrenocorticotropic hormone (ACTH), cortisol, interferon (IFN)-γ, tumor necrosis factor (TNF)-α, and interleukin (IL)-6 were measured at regular intervals after each intervention. The effects of trauma, time, and intervention on these parameters were modeled by fitting linear mixed models. Childhood trauma in itself did not have a main effect on the outcome measurements. However, an interactional effect of trauma with stressor type was found in the remitted MDD group: trauma was associated with higher cortisol levels only after adding immunological to psychosocial stress, and with lower TNF-α levels in response to vaccination. This suggests the existence of a vulnerable trauma-associated MDD endophenotype.

Childhood Trauma, Temperament, and Character in Subjects With Major Depressive Disorder and Bipolar Disorder

2014 ◽  
Vol 202 (9) ◽  
pp. 695-698 ◽  
Author(s):  
Giampaolo Perna ◽  
Giovanna Vanni ◽  
Nunzia Valentina Di Chiaro ◽  
Paolo Cavedini ◽  
Daniela Caldirola
Keyword(s):  
Bipolar Disorder ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Childhood Trauma ◽  
Major Depressive
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