Does comorbid anxiety or depression affect clinical outcomes in patients with post-traumatic stress disorder and alcohol use disorders?

2004 ◽  
Vol 45 (4) ◽  
pp. 304-310 ◽  
Author(s):  
Lawrence A. Labbate ◽  
Susan C. Sonne ◽  
Carrie L. Randal ◽  
Raymond F. Anton ◽  
Kathleen T. Brady
Keyword(s):  
Alcohol Use ◽  
Clinical Outcomes ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Alcohol Use Disorders ◽  
Post Traumatic Stress ◽  
Comorbid Anxiety ◽  
Post Traumatic

scholarly journals One-year clinical outcomes following theta burst stimulation for post-traumatic stress disorder

2019 ◽  
Vol 45 (6) ◽  
pp. 940-946 ◽  
Author(s):  
Nicholas J. Petrosino ◽  
Mascha van ’t Wout-Frank ◽  
Emily Aiken ◽  
Hannah R. Swearingen ◽  
Jennifer Barredo ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Clinical Outcomes ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Magnetic Stimulation ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
Post Traumatic ◽  
One Year ◽  
Theta Burst

AbstractTheta burst transcranial magnetic stimulation (TBS) is a potential new treatment for post-traumatic stress disorder (PTSD). We previously reported active intermittent TBS (iTBS) was associated with superior clinical outcomes for up to 1-month, in a sample of fifty veterans with PTSD, using a crossover design. In that study, participants randomized to the active group received a total of 4-weeks of active iTBS, or 2-weeks if randomized to sham. Results were superior with greater exposure to active iTBS, which raised the question of whether observed effects persisted over the longer-term. This study reviewed naturalistic outcomes up to 1-year from study endpoint, to test the hypothesis that greater exposure to active iTBS would be associated with superior outcomes. The primary outcome measure was clinical relapse, defined as any serious adverse event (e.g., suicide, psychiatric hospitalization, etc.,) or need for retreatment with repetitive transcranial magnetic stimulation (rTMS). Forty-six (92%) of the initial study’s intent-to-treat participants were included. Mean age was 51.0 ± 12.3 years and seven (15.2%) were female. The group originally randomized to active iTBS (4-weeks active iTBS) demonstrated superior outcomes at one year compared to those originally randomized to sham (2-weeks active iTBS); log-rank ChiSq = 5.871, df = 1, p = 0.015; OR = 3.50, 95% CI = 1.04–11.79. Mean days to relapse were 296.0 ± 22.1 in the 4-week group, and 182.0 ± 31.9 in the 2-week group. When used, rTMS retreatment was generally effective. Exploratory neuroimaging revealed default mode network connectivity was predictive of 1-year outcomes (corrected p < 0.05). In summary, greater accumulated exposure to active iTBS demonstrated clinically meaningful improvements in the year following stimulation, and default mode connectivity could be used to predict longer-term outcomes.

scholarly journals Postdeployment Alcohol Use, Aggression, and Post-Traumatic Stress Disorder

2012 ◽  
Vol 177 (10) ◽  
pp. 1184-1190 ◽  
Author(s):  
Janice M. Brown ◽  
Jason Williams ◽  
Robert M. Bray ◽  
Laurel Hourani
Keyword(s):  
Alcohol Use ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
Post Traumatic

Post-traumatic stress disorder and alcohol use disorder

2002 ◽  
Vol 8 (2) ◽  
pp. 55-61 ◽  
Author(s):  
I. Roncevic-Grzeta ◽  
Lj. Moro ◽  
T. Franciskovic ◽  
T. Ruzic ◽  
B. Smokvina ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Alcohol Use Disorder ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
Post Traumatic

Randomized controlled trial of cognitive behaviour therapy for comorbid post-traumatic stress disorder and alcohol use disorders

Addiction ◽  
2013 ◽  
Vol 108 (8) ◽  
pp. 1397-1410 ◽  
Author(s):  
Claudia Sannibale ◽  
Maree Teesson ◽  
Mark Creamer ◽  
Thiagarajan Sitharthan ◽  
Richard A. Bryant ◽  
...  
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Controlled Trial ◽  
Alcohol Use Disorders ◽  
Post Traumatic Stress ◽  
Behaviour Therapy ◽  
Randomized Controlled ◽  
Cognitive Behaviour ◽  
Post Traumatic
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