Adaptive generic product structure modelling for design reuse in engineer-to-order products

2010 ◽  
Vol 61 (1) ◽  
pp. 53-65 ◽  
Author(s):  
Antoine Brière-Côté ◽  
Louis Rivest ◽  
Alain Desrochers
Keyword(s):  
Product Structure ◽  
Generic Product ◽  
Design Reuse ◽  
Engineer To Order

Unzipping Natural Products: Improved Natural Product Structure Predictions by Ensemble Modeling and Fingerprint Matching

2018 ◽  
Author(s):  
William A. Shirley ◽  
Brian P. Kelley ◽  
Yohann Potier ◽  
John H. Koschwanez ◽  
Robert Bruccoleri ◽  
...  
Keyword(s):  
Natural Products ◽  
Open Source ◽  
Natural Product ◽  
Gene Cluster ◽  
Public Domain ◽  
Product Structure ◽  
Fingerprint Matching ◽  
Ensemble Modeling ◽  
Chemical Structures ◽  
Source Gene

This pre-print explores ensemble modeling of natural product targets to match chemical structures to precursors found in large open-source gene cluster repository antiSMASH. Commentary on method, effectiveness, and limitations are enclosed. All structures are public domain molecules and have been reviewed for release.

On the Reaction of 2,5-Dihydroxy-[1,4]-benzoquinone with Diamines – Strain-induced Reactivity Effects

2020 ◽  
Vol 24 ◽  
Author(s):  
Hubert Hettegger ◽  
Andreas Hofinger ◽  
Thomas Rosenau
Keyword(s):  
Nucleophilic Substitution ◽  
Product Structure ◽  
Carbonyl Groups ◽  
Reaction Products ◽  
Double Bonds ◽  
Oh Groups ◽  
Natural Geometry ◽  
Quinoid Structure ◽  
Bond Localization

: The regioselectivity of the reaction of 2,5-dihydroxy-[1,4]-benzoquinone (DHBQ) with diamines could not be explained satisfactorily so far. In general, the reaction products can be derived from the tautomeric ortho-quinoid structure of a hypothetical 4,5-dihydroxy-[1,2]-benzoquinone. However, both aromatic and aliphatic 1,2-diamines form in some cases phenazines, formally by diimine formation on the quinoid carbonyl groups, and in other cases the corresponding 1,2- diamino-[1,2]-benzoquinones, by nucleophilic substitution of the OH groups, the regioselectivity apparently not following any discernible pattern. The reactivity was now explained by an adapted theory of strain-induced bond localization (SIBL). Here, the preservation of the "natural" geometry of the two quinoid C–C double bonds (C3=C4 and C5=C6) as well as the N–N distance of the co-reacting diamine are crucial. A decrease of the annulation angle sum (N–C4–C5 + C4–C5–N) is tolerated well and the 4,5-diamino-ortho-quinones, having relatively short N–N spacings are formed. An increase in the angular sum is energetically unfavorable, so that diamines with a larger N–N distance afford the corresponding ortho-quinone imines. Thus, for the reaction of DHBQ with diamines, exact predictions of the regioselectivity, and the resulting product structure, can be made on the basis of simple computations of bond spacings and product geometries.

scholarly journals Quasi-ideal Ehresmann transversals: The spined product structure

2021 ◽  
Vol 19 (1) ◽  
pp. 77-86
Author(s):  
Xiangjun Kong ◽  
Pei Wang ◽  
Jian Tang
Keyword(s):  
Structure Theorem ◽  
Product Structure ◽  
Abundant Semigroup ◽  
Spined Product ◽  
Equivalent Conditions

Abstract In any U-abundant semigroup with an Ehresmann transversal, two significant components R and L are introduced in this paper and described by Green’s ∼ \sim -relations. Some interesting properties associated with R and L are explored and some equivalent conditions for the Ehresmann transversal to be a quasi-ideal are acquired. Finally, a spined product structure theorem is established for a U-abundant semigroup with a quasi-ideal Ehresmann transversal by means of R and L.

scholarly journals Lean Maturity Assessment in ETO Scenario

2021 ◽  
Vol 11 (9) ◽  
pp. 3833
Author(s):  
Mariastella Chiera ◽  
Francesco Lupi ◽  
Andrea Rossi ◽  
Michele Lanzetta
Keyword(s):  
Lean Manufacturing ◽  
Mathematical Formulation ◽  
Assessment Model ◽  
Assessment Framework ◽  
Lean Product Development ◽  
Lean Assessment ◽  
Assessment And Monitoring ◽  
Mission Management ◽  
Engineer To Order ◽  
Manufacturing Organization

The obligatory path towards a lean manufacturing organization requires assessment and monitoring. However, a lean assessment framework is not yet available for the engineer to order (ETO) scenario. This work explored ten lean ETO maturity principles—identified from the literature—that take insight from three formally defined sets (Toyota Way, lean construction, and lean product development principles). A practical assessment model was proposed based on the evaluation of ten lean ETO objective criteria (four with mathematical formulation) and was validated on a real industrial case. A problem-solving tool, including a new lean tool, called the Problem Focus Matrix (PFM), was also presented; this tool was aimed toward development of an integrated framework that would include the organization mission, management, and continuous improvement.

scholarly journals SUPPORT FOR MANAGING PARTLY CONFIGURABLE MODULAR SYSTEMS

2021 ◽  
Vol 1 ◽  
pp. 2791-2800
Author(s):  
Jarkko Pakkanen ◽  
Teuvo Heikkinen ◽  
Nillo Adlin ◽  
Timo Lehtonen ◽  
Janne Mämmelä ◽  
...  
Keyword(s):  
Portfolio Management ◽  
Product Variety ◽  
Added Value ◽  
Modular System ◽  
Product Management ◽  
Design Decision ◽  
Product Portfolio ◽  
Modular Systems ◽  
Engineer To Order ◽  
The Impact

AbstractThe paper studies what kind of support could be applied to the management of partly configurable modular systems. The main tasks of product management, product portfolio management and product variety management are defined. In addition, a partly configurable product structure and modular system are defined. Because the limited support in the literature for managing partly configurable modular systems, the article reviews previous product development cases in which authors have been involved on lessons learnt basis, i.e., if the methods and tools used in the cases could provide support for the research objective. As a result, the existing definition of the modular system should be extended by the concepts of non-module and design decision sequence description when dealing with partly configurable modular systems. This is because engineer-to-order should be made possible in cases where it brings clear added value to the customer compared to completely pre-defined solutions that may limit the customer's interest in the offering. Tools to assess the impact of changes to the product offering are required. These should be taken into account in frameworks that are used in method and tool development.

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