The effect of Sambucus nigra L. extract and phytosinthesized gold nanoparticles on diabetic rats

2017 ◽  
Vol 150 ◽  
pp. 192-200 ◽  
Author(s):  
Razvan Opris ◽  
Corina Tatomir ◽  
Diana Olteanu ◽  
Remus Moldovan ◽  
Bianca Moldovan ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Diabetic Rats ◽  
Sambucus Nigra

scholarly journals Mechanism bySambucus nigraExtract Improves Bone Mineral Density in Experimental Diabetes

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Laurentiu Badescu ◽  
Oana Badulescu ◽  
Magda Badescu ◽  
Manuela Ciocoiu
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Content ◽  
Diabetic Rats ◽  
Mineral Density ◽  
Sambucus Nigra ◽  
Polyphenolic Extract ◽  
Before And After ◽  
Total Antioxidant ◽  
Diabetic Osteoporosis

The effects of polyphenols extracted fromSambucus nigrafruit were studied in streptozotocin- (STZ-) induced hyperglycemic rats to evaluate its possible antioxidant, anti-inflammatory, antiglycosylation activity, and antiosteoporosis effects in diabetes. DEXA bone mineral density tests were performed in order to determine bone mineral density (BMD), bone mineral content (BMC), and fat (%Fat) in control and diabetic animals, before and after polyphenol delivery. As compared to the normoglycemic group, the rats treated with STZ (60 mg/kg body weight) revealed a significant malondialdehyde (MDA) increase, as an index of the lipid peroxidation level, by 69%, while the total antioxidant activity (TAS) dropped by 36%, with a consistently significant decrease () in the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX). Also, the treatment of rats with STZ revealed a significant increase of IL-6, glycosylated haemoglobin (HbA1c), and osteopenia detected by DEXA bone mineral density tests. The recorded results highlight a significant improvement () in the antioxidative capacity of the serum in diabetic rats treated with natural polyphenols, bringing back to normal the concentration of reduced glutathione (GSH), as well as an important decrease in the serum concentration of MDA, with improved osteoporosis status. Knowing the effects of polyphenols could lead to the use of the polyphenolic extract ofSambucus nigraas a dietary supplement in diabetic osteoporosis.

Improved stability of KGF by conjugation with gold nanoparticles for diabetic wound therapy

Nanomedicine ◽  
2019 ◽  
Vol 14 (22) ◽  
pp. 2909-2923 ◽  
Author(s):  
Shuaihua Li ◽  
Qiyu Tang ◽  
Hongbo Xu ◽  
Qiangru Huang ◽  
Zi Wen ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Wound Healing ◽  
Binding Affinity ◽  
Biological Effects ◽  
Diabetic Rats ◽  
Diabetic Wound ◽  
Wound Therapy ◽  
Improved Stability ◽  
Diabetic Wound Healing

Aim: Diabetic wound healing is seriously interrupted, and administration of KGF for wound treatment is restricted by its inherent instability. We aim to develop an ideal way toward KGF stabilization, thus improving diabetic wound healing. Materials & methods: We conjugated KGF with gold nanoparticles (GNPs) and determined the stability and binding affinity. Biological effects of conjugates (KGF-GNPs) were evaluated in vitro and in an animal model. Results: KGF-GNPs revealed high stability under hostile circumstances because of the preserved secondary structure and possessed elevated binding affinity to KGF receptor. Moreover, application of KGF-GNPs contributed to accelerated wound recovery in diabetic rats, including re-epithelialization and contraction. Conclusion: KGF-GNPs were promising for future clinical application for diabetic wound therapy.

Green synthesis of stable nanocolloids of monodisperse silver and gold nanoparticles using natural polyphenols from fruits of Sambucus nigra L.

2020 ◽  
Vol 10 (12) ◽  
pp. 4545-4558
Author(s):  
Ruslan Mariychuk ◽  
Janka Porubská ◽  
Marek Ostafin ◽  
Mária Čaplovičová ◽  
Adriana Eliašová
Keyword(s):  
Gold Nanoparticles ◽  
Green Synthesis ◽  
Sambucus Nigra ◽  
Silver And Gold Nanoparticles ◽  
Natural Polyphenols

scholarly journals Effect of Elderberry (Sambucus nigra L.) Extract Supplementation in STZ-Induced Diabetic Rats Fed with a High-Fat Diet

2016 ◽  
Vol 18 (1) ◽  
pp. 13 ◽  
Author(s):  
Ângelo Salvador ◽  
Ewelina Król ◽  
Virgínia Lemos ◽  
Sónia Santos ◽  
Fernanda Bento ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Diabetic Rats ◽  
High Fat ◽  
Sambucus Nigra

Antidiabetic assessment; in vivo study of gold and core-shell silver-gold nanoparticles on streptozotocin-induced diabetic rats

2016 ◽  
Vol 83 ◽  
pp. 865-875 ◽  
Author(s):  
Th. I. Shaheen ◽  
Mehrez E. El-Naggar ◽  
Jihan S. Hussein ◽  
Mona El-Bana ◽  
Enayat Emara ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Diabetic Rats ◽  
In Vivo Study ◽  
Core Shell

Effect of biosynthesized gold nanoparticles by Sargassum swartzii in alloxan induced diabetic rats

2016 ◽  
Vol 95 ◽  
pp. 100-106 ◽  
Author(s):  
T. Stalin Dhas ◽  
V. Ganesh Kumar ◽  
V. Karthick ◽  
K. Vasanth ◽  
G. Singaravelu ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Diabetic Rats ◽  
Sargassum Swartzii

Effect of biologically synthesized gold nanoparticles on alloxan-induced diabetic rats—An in vivo approach

2014 ◽  
Vol 122 ◽  
pp. 505-511 ◽  
Author(s):  
V. Karthick ◽  
V. Ganesh Kumar ◽  
T. Stalin Dhas ◽  
G. Singaravelu ◽  
A. Mohamed Sadiq ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Diabetic Rats

scholarly journals Gold Nanoparticles Ameliorate Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Rats

2021 ◽  
Vol 1231 ◽  
pp. 130009
Author(s):  
Alaa A A Aljabali ◽  
Bahaa Al-Trad ◽  
Lina Al Gazo ◽  
Ghada Alomari ◽  
Mazhar Al Zoubi ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Diabetic Cardiomyopathy ◽  
Diabetic Rats
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