In vitro biocompatibility of magnetic thermo-responsive nanohydrogel particles of poly(N-isopropylacrylamide-co-acrylic acid) with Fe3O4 cores: Effect of particle size and chemical composition

2013 ◽  
Vol 104 ◽  
pp. 66-74 ◽  
Author(s):  
Feng-Yi Chou ◽  
Jui-Yang Lai ◽  
Chao-Ming Shih ◽  
Meng-Chao Tsai ◽  
Shingjiang Jessie Lue
Keyword(s):  
Particle Size ◽  
Chemical Composition ◽  
Acrylic Acid ◽  
In Vitro Biocompatibility ◽  
Effect Of Particle Size

In vitro permeation of gold nanoparticles through rat skin and rat intestine: Effect of particle size

2008 ◽  
Vol 65 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Ganeshchandra Sonavane ◽  
Keishiro Tomoda ◽  
Akira Sano ◽  
Hiroyuki Ohshima ◽  
Hiroshi Terada ◽  
...  
Keyword(s):  
Particle Size ◽  
Gold Nanoparticles ◽  
Rat Skin ◽  
Rat Intestine ◽  
In Vitro Permeation ◽  
Effect Of Particle Size

Rutin nanosuspension for potential management of osteoporosis: effect of particle size reduction on oral bioavailability, in vitro and in vivo activity

2020 ◽  
Vol 25 (8) ◽  
pp. 971-988
Author(s):  
Sonia Gera ◽  
Venkatesh Pooladanda ◽  
Chandraiah Godugu ◽  
Veerabhadra Swamy Challa ◽  
Jitendra Wankar ◽  
...  
Keyword(s):  
Particle Size ◽  
Oral Bioavailability ◽  
Size Reduction ◽  
Particle Size Reduction ◽  
Effect Of Particle Size

scholarly journals Effect of particle size on the chemical composition of Ti–Ni-base spark erosion powder obtained in liquid argon

2011 ◽  
Vol 4 (3/4) ◽  
pp. 188-199 ◽  
Author(s):  
Gennady MONASTYRSKY ◽  
◽  
Patrick OCHIN ◽  
Guillaume Y. WANG ◽  
Victor KOLOMYTSEV ◽  
...  
Keyword(s):  
Particle Size ◽  
Chemical Composition ◽  
Liquid Argon ◽  
Spark Erosion ◽  
Effect Of Particle Size

Effect of particle size on in vitro fermentation of silages differing in dry matter content

1997 ◽  
Vol 1997 ◽  
pp. 197-197
Author(s):  
R. Sanderson ◽  
S.J. Lister ◽  
A. Sargeant ◽  
M.S. Dhanoa
Keyword(s):  
Particle Size ◽  
Dry Matter ◽  
Matter Content ◽  
Dry Matter Content ◽  
In Vitro Fermentation ◽  
Freeze Dried ◽  
Effect Of Particle Size

The objectives of this study were a) to examine the effect of particle size and silage dry matter (DM) content on the rate and pattern of fermentation of fresh silages in vitro as an aid to modelling the in vivo situation and b) to compare the rate and pattern of fermentation of fresh silage samples with those obtained for freeze-dried material.

Effect of particle size on macrophage-osteoclast differentiation in vitro

2001 ◽  
Vol 6 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Takahisa Hirayama ◽  
Yosuke Fujikawa ◽  
Ichiro Itonaga ◽  
Takehiko Torisu
Keyword(s):  
Particle Size ◽  
Osteoclast Differentiation ◽  
Effect Of Particle Size

Serum Proteins Opsonization and Phagocytic Uptake of PEG-Modified PLGA Nanoparticles: Effect of Particle Size

2011 ◽  
Vol 393-395 ◽  
pp. 939-942 ◽  
Author(s):  
An Shu Yang ◽  
Wei Liu ◽  
Xiang Liang Yang
Keyword(s):  
Particle Size ◽  
Serum Protein ◽  
Complement Activation ◽  
Serum Proteins ◽  
Enzyme Linked Immunosorbent Assay ◽  
Spontaneous Emulsification ◽  
Protein Assay ◽  
Effect Of Particle Size ◽  
Serum Dependent

The purpose of this study is to evaluate the effect of particle size on serum protein opsonization and in vitro macrophage uptake of polyethyleneglycol modified poly (D, L-lactide-co-glycolide) nanoparticles (PEG-PLGA-NPs). PEG-PLGA-NPs were prepared by modified-spontaneous emulsification solvent diffusion (modified-SESD) method. Serum protein adsorptions to PEG-PLGA-NPs were evaluated by bicinchoninic acid (BCA) protein assay and enzyme-linked immunosorbent assay (ELISA). Complement activation was also investigated by ELISA for complement fragments iC3b. Uptake of PEG-PLGA-NPs by macrophages was measured by fluorescence spectrometer. The results showed that serum protein adsorption and complement activation were augmented for nanoparticles with a larger size below 400 nm. Phagocytosis of PEG-PLGA-NPs by murine peritoneal macrophages involved serum-independent and serum-dependent phagocytosis. Serum-independent phagocytosis decreased, while serum-dependent phagocytosis increased with the increase of particle size in the nanometer and submicrometer range. Consequently, nanoparticles with size of about 400 nm were phagocytosed more readily than either smaller or larger particles

Poly(acrylamide co-acrylic acid) for use as an in situ gelling vitreous substitute

2017 ◽  
Vol 32 (5) ◽  
pp. 528-541 ◽  
Author(s):  
Joshua T Davis ◽  
Paul D Hamilton ◽  
Nathan Ravi
Keyword(s):  
Acrylic Acid ◽  
Retinal Pigment ◽  
Water Soluble ◽  
Retinal Pigment Epithelial Cells ◽  
Feed Ratio ◽  
Impedance Sensing ◽  
In Vitro Biocompatibility ◽  
Vitreous Substitutes

Our objective is to improve on our previous work developing thiol-containing water-soluble copolyacrylamides that form hydrogels in situ for use as vitreous substitutes. In this study, we evaluate the incorporation of acrylic acid by varying the feed ratio of acrylic acid monomer from 0 to 40 mol% in combination with acrylamide, and bis-acryloylcystamine as the reversible cross-linker. After polymerization, the formed copolymer hydrogels were reduced with dithiothreitol to cleave the disulfide cross-linkers. Purified, lyophilized copolymers were made in a concentration range of 12.5–17.5 mg/mL (polymer in deionized water) and were gelled by oxidation. Chemical, physical, optical, and rheological characterizations along with in vitro biocompatibility studies were performed using thiazolyl blue and Electric Cell–substrate Impedance Sensing. Increasing the percentage of acrylic acid caused the polymer to gel at 12.5 mg/mL as opposed to 20 mg/mL without acrylic acid. Storage modulus values covered the range of natural vitreous (1–108 Pa). Biocompatibility testing in tissue culture with retinal pigment epithelial cells (ARPE-19) showed no toxicity at 10 mg/mL or less when compared to controls, higher concentrations. In contrast to our previously reported copolyacrylamide hydrogels, these hydrogels remain optically clear and gel at lower concentrations and have the potential for use as vitreous substitutes.

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