A study of pH effects on the bacterial surface physicochemical properties of Acinetobacter baumannii

2013 ◽  
Vol 102 ◽  
pp. 540-545 ◽  
Author(s):  
Ryad Djeribi ◽  
Zahia Boucherit ◽  
Warda Bouchloukh ◽  
Wafa Zouaoui ◽  
Hassan Latrache ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Acinetobacter Baumannii ◽  
Ph Effects ◽  
Bacterial Surface ◽  
Surface Physicochemical Properties

scholarly journals Mining of Gram-Negative Surface-Active Enzybiotic Candidates by Sequence-Based Calculation of Physicochemical Properties

2021 ◽  
Vol 12 ◽  
Author(s):  
Roberto Vázquez ◽  
Sofía Blanco-Gañán ◽  
Susana Ruiz ◽  
Pedro García
Keyword(s):  
Physicochemical Properties ◽  
Nearest Neighbors ◽  
Regulatory Agencies ◽  
Gram Negative Bacteria ◽  
Wild Type ◽  
Gram Negative ◽  
Bacterial Surface ◽  
Negative Surface ◽  
Surface Active ◽  
Phage Lysins

Phage (endo)lysins are nowadays one of the most promising ways out of the current antibiotic resistance crisis. Either as sole therapeutics or as a complement to common antibiotic chemotherapy, lysins are already entering late clinical phases to get regulatory agencies’ authorization. Even the old paradigm of the inability of lysins to attack Gram-negative bacteria from without has already been overcome in a variety of ways: either by engineering approaches or investigating the natural mechanisms by which some wild-type lysins are able to interact with the bacterial surface. Such inherent ability of some lysins has been linked to antimicrobial peptide (AMP)-like regions, which are, on their own, a significant source for novel antimicrobials. Currently, though, many of the efforts for searching novel lysin-based antimicrobial candidates rely on experimental screenings. In this work, we have bioinformatically analyzed the C-terminal end of a collection of lysins from phages infecting the Gram-negative genus Pseudomonas. Through the computation of physicochemical properties, the probability of such regions to be an AMP was estimated by means of a predictive k-nearest neighbors (kNN) model. This way, a subset of putatively membrane-interacting lysins was obtained from the original database. Two of such candidates (named Pae87 and Ppl65) were prospectively tested in terms of muralytic, bacteriolytic, and bactericidal activity. Both of them were found to possess an activity against Pseudomonas aeruginosa and other Gram-negative bacterial pathogens, implying that the prediction of AMP-like regions could be a useful approach toward the mining of phage lysins to design and develop antimicrobials or antimicrobial parts for further engineering.

Different defect morphologies in polyethylene crystal induced by surface physicochemical properties

2020 ◽  
Vol 31 (6) ◽  
pp. 1640-1643
Author(s):  
Yaqi Hou ◽  
Yi Ye ◽  
Zhongjie Du ◽  
Chen Zhang ◽  
Jianguo Mi ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Surface Physicochemical Properties

scholarly journals Correlation between cell surface physicochemical properties of bacterial strains and their chromium removal potential

2017 ◽  
Vol 31 (24) ◽  
pp. 2730-2740 ◽  
Author(s):  
Meryem Asri ◽  
Alae Elabed ◽  
Nabil Tirry ◽  
Aziza Kouchou ◽  
Saad Ibnsouda Koraichi ◽  
...  
Keyword(s):  
Cell Surface ◽  
Physicochemical Properties ◽  
Chromium Removal ◽  
Bacterial Strains ◽  
Surface Physicochemical Properties
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