Drug release behavior of hydrophobic drug-loaded poly (lactide-co-glycolide) nanoparticles: Effects of glass transition temperature

2017 ◽  
Vol 529 ◽  
pp. 328-333 ◽  
Author(s):  
Issei Takeuchi ◽  
Shunsuke Yamaguchi ◽  
Satoru Goto ◽  
Kimiko Makino
Keyword(s):  
Glass Transition ◽  
Transition Temperature ◽  
Glass Transition Temperature ◽  
Drug Release ◽  
Release Behavior ◽  
Hydrophobic Drug ◽  
Drug Release Behavior

Potential Roles of the Glass Transition Temperature of PLGA Microparticles in Drug Release Kinetics

2020 ◽  
Vol 18 (1) ◽  
pp. 18-32
Author(s):  
Kinam Park ◽  
Andrew Otte ◽  
Farrokh Sharifi ◽  
John Garner ◽  
Sarah Skidmore ◽  
...  
Keyword(s):  
Glass Transition ◽  
Transition Temperature ◽  
Glass Transition Temperature ◽  
Drug Release ◽  
Release Kinetics ◽  
Drug Release Kinetics ◽  
Plga Microparticles

scholarly journals Estimation of the apparent glass transition temperature of spray-dried emulsified powders and yeast powders by their flavor release behavior under temperature ramping conditions

2018 ◽  
Author(s):  
A. Sultana ◽  
J. L. Zhu ◽  
H. Yoshii
Keyword(s):  
Glass Transition ◽  
Transition Temperature ◽  
Glass Transition Temperature ◽  
Spray Drying ◽  
Yeast Cells ◽  
Release Behavior ◽  
Simple Method ◽  
Flavor Release ◽  
Yeast Powder ◽  
Spray Dried

Flavor release from powders depends on the glass transition temperature (Tg) and water absorption. This study reports a simple method to estimate the apparent Tg by aroma sensing upon flavor release from spray-dried powders. Four different wall materials (maltodextrin (MD), MD blends with fructose at 20 and 40wt%, and yeast cells) were used to encapsulate flavors by spray-drying. The apparent Tg values of MD and MD with 20 and 40wt% fructose were determined as 130, 110, and 75 °C, respectively, similar to those calculated by the Gordon–Taylor equation. The slow flavor release from dried-yeast powder afforded the highest Tg. Keywords: yeast; flavor; encapsulation; spray drying; aroma sensor.

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