Physicochemical studies on the catanionics of alkyltrimethylammonium bromides and bile salts in aqueous media

2012 ◽  
Vol 415 ◽  
pp. 10-21 ◽  
Author(s):  
Kausik Manna ◽  
Chien-Hsiang Chang ◽  
Amiya Kumar Panda
Keyword(s):  
Bile Salts ◽  
Aqueous Media ◽  
Alkyltrimethylammonium Bromides ◽  
Physicochemical Studies

scholarly journals Oral Bioavailability and Lymphatic Transport of Pueraria Flavone-Loaded Self-Emulsifying Drug-Delivery Systems Containing Sodium Taurocholate in Rats

Pharmaceutics ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 147 ◽  
Author(s):  
Jin Qiao ◽  
Danyang Ji ◽  
Shilin Sun ◽  
Guangyuan Zhang ◽  
Xin Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Oral Bioavailability ◽  
Bile Salts ◽  
Drug Delivery Systems ◽  
Aqueous Media ◽  
Sodium Taurocholate ◽  
Delivery Systems ◽  
Lymphatic Transport ◽  
Porcine Pancreas

We developed self-microemulsifying drug-delivery systems (SMEDDS), including bile salts, to improve the oral bioavailability of pueraria flavones (PFs). The physical properties of the SMEDDS using Cremophor RH 40, and bile salts as mixed surfactants at weight ratios of 10:0–0:10 were determined. The particle sizes of PFs-SMEDDSNR containing sodium taurocholate (NaTC) and Cremophor RH 40, and PFs-SMEDDSR containing Cremophor RH 40 were measured upon dilution with deionized water and other aqueous media. Dilution volume presented no remarkable effects on particle size, whereas dilution media slightly influenced particle size. PFs-SMEDDSNR and PFs-SMEDDSR provided similar release rates in pH-1.2 hydrochloride solution. However, the release rate of PFs-SMEDDSNR was faster than that of PFs-SMEDDSR in pH-6.8 phosphate buffer containing 20 mM NaTC and 500 U/mL porcine pancreas lipase. The pharmacokinetics and bioavailability were measured in rats. The oral bioavailability of PFs-SMEDDSNR was 2.57- and 2.28-fold that of a suspension of PFs (PFs-suspension) before and after the blockade of the lymphatic transport route by cycloheximide, respectively. These results suggested PFs-SMEDDSNR could significantly improve the oral relative absorption of PFs via the lymphatic uptake pathway. SMEDDS containing NaTC may provide an effective approach for enhancing the oral bioavailability of PFs.

scholarly journals Micellar solubilization of fatty acids in aqueous media containing bile salts and phospholipids

1976 ◽  
Vol 35 (1) ◽  
pp. 77-87 ◽  
Author(s):  
A. Smith ◽  
A. K. Lough
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Aqueous Solutions ◽  
Bile Salts ◽  
Micellar Solution ◽  
Unsaturated Fatty Acids ◽  
Aqueous Media ◽  
Micellar Solubilization ◽  
Acid Solubility ◽  
Ph Range

1. The solubility of fatty acids in aqueous media containing bile salts alone and in admixture with either lecithin (phosphatidylcholine) or phosphatidylethanolamine was determined.2. Over the pH range 2.0–7.4, the order of fatty acid solubility in aqueous solutions containing bile salts was linoleic > oleic > elaidic > palmitic > stearic. The solubility of each fatty acid increased as the pH of the micellar solution increased.3. Addition of lecithin to aqueous solutions of bile salts greatly increased the solubility of palmitic acid and stearic acid.4. In the presence of bile salts and lecithin, the solubility of oleic acid and elaidic acid decreased with increasing pH of the micellar solution, indicating a competitive effect between the fatty acid anions and lecithin. The solubility of linoleic acid increased linearly with lecithin concentration.5. Phosphatidylethanolamine as an additive to bile salts increased the solubility of both saturated and unsaturated fatty acids in the pH range 2.0–7.4. The effectiveness of phosphatidylethanolamine as an amphiphile was similar to that of lecithin, although at pH 3.0 fatty acid solubility was greater in the presence of phosphatidylethanolamine.6. The significance of these findings is discussed in relation to the intestinal absorption of fatty acids in sheep.

Highly efficient and selective photocatalytic CO2 to CO conversion in aqueous solution

2020 ◽  
Vol 56 (27) ◽  
pp. 3851-3854 ◽  
Author(s):  
Xiaomin Chai ◽  
Hai-Hua Huang ◽  
Huiping Liu ◽  
Zhuofeng Ke ◽  
Wen-Wen Yong ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Photocatalytic Performance ◽  
Aqueous Media ◽  
Highly Efficient ◽  
Co Conversion

A Co-based complex displayed the highest photocatalytic performance for CO2 to CO conversion in aqueous media.

The Biological Importance of Bile Salts

1979 ◽  
Vol 7 (6) ◽  
pp. 1323-1323
Author(s):  
H. DANIELSSON
Keyword(s):  
Bile Salts ◽  
Biological Importance
Sign in / Sign up

Export Citation Format

Share Document