In situ polymerization of conducting polyaniline in bicontinuous cubic phase of lyotropic liquid crystal

Author(s):  
P.S. Khiew ◽  
S. Radiman ◽  
N.M. Huang ◽  
C.S. Kan ◽  
Md. Soot Ahmad
2010 ◽  
Vol 22 (16) ◽  
pp. 4525-4527 ◽  
Author(s):  
Evan S. Hatakeyama ◽  
Brian R. Wiesenauer ◽  
Christopher J. Gabriel ◽  
Richard D. Noble ◽  
Douglas L. Gin

Author(s):  
Josephine Y.T. Chong ◽  
Xavier Mulet ◽  
Ben J. Boyd ◽  
Calum J. Drummond

2007 ◽  
Vol 79 (3) ◽  
pp. 1173-1180 ◽  
Author(s):  
Pawel Rowinski ◽  
Chan Kang ◽  
Hyosul Shin ◽  
Adam Heller

2007 ◽  
Vol 129 (31) ◽  
pp. 9574-9575 ◽  
Author(s):  
Meijuan Zhou ◽  
Parag R. Nemade ◽  
Xiaoyun Lu ◽  
Xiaohui Zeng ◽  
Evan S. Hatakeyama ◽  
...  

Soft Matter ◽  
2019 ◽  
Vol 15 (22) ◽  
pp. 4460-4466
Author(s):  
Weiheng Huang ◽  
Shenghui Wei ◽  
Daan Frenkel ◽  
Ningdong Huang

In situ investigations on the formation of a lyotropic liquid crystal phase through supramolecular assembly in solution suggest a multi-step pathway.


2012 ◽  
Vol 25 (1) ◽  
pp. 114-114 ◽  
Author(s):  
Blaine M. Carter ◽  
Brian R. Wiesenauer ◽  
Evan S. Hatakeyama ◽  
John L. Barton ◽  
Richard D. Noble ◽  
...  

2018 ◽  
Vol 67 ◽  
pp. 99-110 ◽  
Author(s):  
Liling Mei ◽  
Yecheng Xie ◽  
Ying Huang ◽  
Bei Wang ◽  
Jintian Chen ◽  
...  

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Dianfan Li ◽  
Martin Caffrey

Abstract Membrane proteins play vital roles in the life of the cell and are important therapeutic targets. Producing them in large quantities, pure and fully functional is a major challenge. Many promising projects end when intractable aggregates or precipitates form. Here we show how such unfolded aggregates can be solubilized and the solution mixed with lipid to spontaneously self-assemble a bicontinuous cubic mesophase into the bilayer of which the protein, in a confined, chaperonin-like environment, reconstitutes with 100% efficiency. The test protein, diacylglycerol kinase, reconstituted in the bilayer of the mesophase, was then crystallized in situ by the in meso or lipid cubic phase method providing an X-ray structure to a resolution of 2.55 Å. This highly efficient, inexpensive, simple and rapid approach should find application wherever properly folded, membrane reconstituted and functional proteins are required where the starting material is a denatured aggregate.


Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2275 ◽  
Author(s):  
Zhuanzhuan Yang ◽  
Xin Liang ◽  
Xiaojing Jiang ◽  
Jian Guo ◽  
Yaotian Tao ◽  
...  

In the present study, an injectable in situ liquid crystal formulation was developed for local delivery of minocycline hydrochloride (MH) for chronic periodontitis treatment. The physicochemical properties, phase structures, in vitro drug release and pharmacodynamics of in situ liquid crystals were investigated. The optimal formulation (phytantriol (PT)/propylene glycol (PG)/water, 63/27/10, w/w/w) loaded with 20 mg/g MH was proved to be injectable. The precursor formulation can form a cubic phase gel in excess water in 6.97 ± 0.10 s. The results of in vitro drug release suggested the MH presented a sustained release for 4 days. Liquid crystal precursor formulation significantly reduced gingival index, probing depth and alveolar bone loss compared to the model group (p < 0.01). Besides, the pathological characteristics of model rats were improved. The results suggested that MH-loaded in situ cubic liquid crystal possessed of sustained release ability and periodontal clinical symptoms improvement. The developed in situ cubic liquid crystal may be a potentially carrier in the local delivery of MH for periodontal diseases.


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