HIV vaccine design: the neutralizing antibody conundrum

2012 ◽  
Vol 24 (3) ◽  
pp. 316-323 ◽  
Author(s):  
Leonidas Stamatatos
Keyword(s):  
Vaccine Design ◽  
Neutralizing Antibody ◽  
Hiv Vaccine

HIV vaccine design and the neutralizing antibody problem

2004 ◽  
Vol 5 (3) ◽  
pp. 233-236 ◽  
Author(s):  
Dennis R Burton ◽  
Ronald C Desrosiers ◽  
Robert W Doms ◽  
Wayne C Koff ◽  
Peter D Kwong ◽  
...  
Keyword(s):  
Vaccine Design ◽  
Neutralizing Antibody ◽  
Hiv Vaccine

A Boost for HIV Vaccine Design

Science ◽  
2010 ◽  
Vol 329 (5993) ◽  
pp. 770-773 ◽  
Author(s):  
D. R. Burton ◽  
R. A. Weiss
Keyword(s):  
Vaccine Design ◽  
Hiv Vaccine

scholarly journals Contrasting Adult and Infant Immune Responses to HIV Infection and Vaccination

2015 ◽  
Vol 23 (2) ◽  
pp. 84-94 ◽  
Author(s):  
David R. Martinez ◽  
Sallie R. Permar ◽  
Genevieve G. Fouda
Keyword(s):  
Immune Responses ◽  
Hiv Infection ◽  
Vaccine Efficacy ◽  
Neutralizing Antibody ◽  
Hiv Vaccine ◽  
Antibody Responses ◽  
Hiv Vaccines ◽  
Vaccine Candidates ◽  
Protective Antibodies ◽  
Pediatric Populations

ABSTRACTExtensive studies have demonstrated that infant immune responses are distinct from those of adults. Despite these differences, infant immunization can elicit protective immune responses at levels comparable to or, in some cases, higher than adult immune responses to many vaccines. To date, only a few HIV vaccine candidates have been tested in infant populations, and none of them evaluated vaccine efficacy. Recent exciting studies showing that HIV-infected infants can develop broad neutralizing antibody responses and that some HIV vaccine regimens can elicit high levels of potentially protective antibodies in infants provide support for the development and testing of HIV vaccines in pediatric populations. In this review, we discuss the differences in adult and infant immune responses in the setting of HIV infection and vaccination.

Anti-Carbohydrate HIV Vaccine Design

2013 ◽  
pp. 143-176
Author(s):  
Lai-Xi Wang ◽  
Paolo Costantino ◽  
Yu Geng ◽  
Hong Zhang
Keyword(s):  
Vaccine Design ◽  
Hiv Vaccine

A call for replicating vector prime-protein boost strategies in HIV vaccine design

2004 ◽  
Vol 3 (sup1) ◽  
pp. S105-S117 ◽  
Author(s):  
Nina V Malkevitch ◽  
Marjorie Robert-Guroff
Keyword(s):  
Vaccine Design ◽  
Hiv Vaccine ◽  
Protein Boost

scholarly journals Characterization of two engineered dimeric Zika virus envelope proteins as immunogens for neutralizing antibody selection and vaccine design

2019 ◽  
Vol 294 (27) ◽  
pp. 10638-10648 ◽  
Author(s):  
Chunpeng Yang ◽  
Fang Zeng ◽  
Xinyu Gao ◽  
Shaojuan Zhao ◽  
Xuan Li ◽  
...  
Keyword(s):  
Zika Virus ◽  
Vaccine Design ◽  
Neutralizing Antibody ◽  
Envelope Proteins ◽  
Virus Envelope
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