Evaluation of bone dose arising from skin cancer brachytherapy: A comparison between 192Ir and 60Co sources through Monte Carlo simulations

Monte Carlo simulations for optimal light delivery in photodynamic therapy of non-melanoma skin cancer

Physics in Medicine and Biology ◽

10.1088/0031-9155/57/20/6327 ◽

2012 ◽

Vol 57 (20) ◽

pp. 6327-6345 ◽

Cited By ~ 19

Author(s):

R M Valentine ◽

K Wood ◽

C T A Brown ◽

S H Ibbotson ◽

H Moseley

Keyword(s):

Monte Carlo ◽

Photodynamic Therapy ◽

Skin Cancer ◽

Monte Carlo Simulations ◽

Light Delivery ◽

Non Melanoma Skin Cancer ◽

Melanoma Skin

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Monte Carlo Simulations of Heat Deposition During Photothermal Skin Cancer Therapy Using Nanoparticles

Biomolecules ◽

10.3390/biom9080343 ◽

2019 ◽

Vol 9 (8) ◽

pp. 343

Author(s):

J. Charles G. Jeynes ◽

Freddy Wordingham ◽

Laura J. Moran ◽

Alison Curnow ◽

Tim J. Harries

Keyword(s):

Monte Carlo ◽

Skin Cancer ◽

Monte Carlo Simulations ◽

Photothermal Therapy ◽

Normal Tissue ◽

Heat Diffusion ◽

Thermal Dose ◽

Plasmonic Nanoparticle ◽

Heat Deposition ◽

Invaluable Tool

Photothermal therapy using nanoparticles is a promising new approach for the treatment of cancer. The principle is to utilise plasmonic nanoparticle light interaction for efficient heat conversion. However, there are many hurdles to overcome before it can be accepted in clinical practice. One issue is a current poor characterization of the thermal dose that is distributed over the tumour region and the surrounding normal tissue. Here, we use Monte Carlo simulations of photon radiative transfer through tissue and subsequent heat diffusion calculations, to model the spatial thermal dose in a skin cancer model. We validate our heat rise simulations against experimental data from the literature and estimate the concentration of nanorods in the tumor that are associated with the heat rise. We use the cumulative equivalent minutes at 43 °C (CEM43) metric to analyse the percentage cell kill across the tumour and the surrounding normal tissue. Overall, we show that computer simulations of photothermal therapy are an invaluable tool to fully characterize thermal dose within tumour and normal tissue.

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Low-voltage EDS of magnesium ferrite Dendrites in a FEG-SEM

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100164854 ◽

1996 ◽

Vol 54 ◽

pp. 478-479

Author(s):

Matthew T. Johnson ◽

Ian M. Anderson ◽

Jim Bentley ◽

C. Barry Carter

Keyword(s):

Monte Carlo ◽

Quantitative Analysis ◽

Monte Carlo Simulations ◽

Cross Section ◽

Spatial Resolution ◽

Low Voltage ◽

Magnesium Ferrite ◽

X Ray ◽

Interaction Volume ◽

Ferrite Spinel

Energy-dispersive X-ray spectrometry (EDS) performed at low (≤ 5 kV) accelerating voltages in the SEM has the potential for providing quantitative microanalytical information with a spatial resolution of ∼100 nm. In the present work, EDS analyses were performed on magnesium ferrite spinel [(MgxFe1−x)Fe2O4] dendrites embedded in a MgO matrix, as shown in Fig. 1. spatial resolution of X-ray microanalysis at conventional accelerating voltages is insufficient for the quantitative analysis of these dendrites, which have widths of the order of a few hundred nanometers, without deconvolution of contributions from the MgO matrix. However, Monte Carlo simulations indicate that the interaction volume for MgFe2O4 is ∼150 nm at 3 kV accelerating voltage and therefore sufficient to analyze the dendrites without matrix contributions.Single-crystal {001}-oriented MgO was reacted with hematite (Fe2O3) powder for 6 h at 1450°C in air and furnace cooled. The specimen was then cleaved to expose a clean cross-section suitable for microanalysis.

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